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Drug for treating elderly intractable insomnia and preparation method of drug

A technology for obstinate and elderly people, which is applied in the field of traditional Chinese medicine for the treatment of intractable insomnia. It can solve the problems of not fundamentally improving sleep quality, damaging sleep components, and making no breakthroughs, so as to protect brain cells and improve sleep. Quality, the effect of no adverse reactions

Inactive Publication Date: 2013-04-17
韩多林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sedative and hypnotic drugs have extensive inhibitory effects on the central nervous system. Such drugs can cause severe liver and kidney toxicity, and long-term use can also produce side effects such as tolerance and dependence.
In recent years, the use of benzodiazepines still has drug addiction, dependence, and hangover phenomena, and can also cause memory damage and is accompanied by more serious drug withdrawal reactions and insomnia rebound phenomena.
More importantly, although these drugs can prolong the total sleep time, they impair the two most important sleep components in the sleep process, slow wave sleep (SWS) and rapid eye movement sleep (REMS), which prolong only It is light sleep, but it does not fundamentally improve the quality of sleep
[0004] At present, great progress has been made in the pathogenesis and diagnosis of insomnia at home and abroad, but there is still no breakthrough in treatment.

Method used

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  • Drug for treating elderly intractable insomnia and preparation method of drug
  • Drug for treating elderly intractable insomnia and preparation method of drug
  • Drug for treating elderly intractable insomnia and preparation method of drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Weighing of raw materials: Purple Salvia 3kg, Angelica 2.0kg, Coptidis 0.6, Semen jujube 2.0kg, Cinnamon 1.0kg, Radix Paeoniae Alba 2.0kg, Digupi 1.2kg, Poria cocos 1.5kg, Rhizoma Chuanxiong 1.0kg, Tempeh 2.0kg , Ophiopogon japonicus 1.5kg, Passepartout 1.5kg, raw astragalus 3.0kg, Sichuan Achyranthes bidentata 2.0kg, lily 1.5kg and roasted licorice 3.0kg.

[0018] (2) After mixing the above medicines, add water to decoct twice, the first time add 3 times the total weight of medicinal materials, decoct for 2 hours, take 28-32kg of juice, and add 2 times the total weight of medicinal materials for the second time water, decocted for 1.5 hours, took the juice, combined the decoction, filtered, the temperature of the filtrate was controlled at 80°C, concentrated to a thick paste with a relative density of 1.12, fully stirred, and dried at a low temperature of 1-5°C to obtain a dry extract 3.0 kg, add 450 g of starch, granulate, pulverize into fine powder, pack into cap...

Embodiment 2

[0023] (1) Weighing of raw materials: 2.5kg of purple salvia miltiorrhiza, 2.5kg of angelica, 0.7kg of berberine, 1.8kg of jujube seed, 0.8kg of cinnamon, 1.8kg of white peony root, 1.1kg of Digupi, 1.2kg of poria cocos, 0.8kg of chuanxiong, Tempeh 1.5kg, Ophiopogon japonicus 1.2kg, Passepartout 1.2kg, raw astragalus 2.5kg, Sichuan Achyranthes bidentata 1.5kg, lily 1.2kg, roasted licorice 2.5kg.

[0024] (2) After mixing the above medicines, add water and decoct twice. For the first time, add water 3 times the total weight of the medicinal materials, decoct for 2 hours, take 25-28 kg of juice, and add 1.8 times the total weight of the medicinal materials for the second time. water, decoct for 1.5 hours, take the juice, combine the decoction, filter, and control the temperature of the filtrate at 70°C, concentrate it to a thick paste with a relative density of 1.12 for preparation, fully stir, and dry at a low temperature of 1-5°C to obtain a dry extract 2.8 kg, add 420g of sta...

Embodiment 3

[0029] (1) Raw material weighing: 2kg of purple salvia, 1.5kg of angelica, 0.6kg of coptis, 1.5kg of jujube seed, 0.6kg of cinnamon, 1.5kg of white peony, 1.0kg of digupi, 1.0kg of poria cocos, 0.6kg of chuanxiong, 1.5 kg, Ophiopogon japonicus 1.0kg, Passepartout 1.0kg, raw astragalus 2.0kg, Achyranthes bidentata 1.5kg, lily 1.0kg and Zhilicorice 2.0.

[0030] (2) After mixing the above medicines, add water to decoct twice, add 2.5 times the total weight of medicinal materials for the first time, decoct for 2 hours, take 22-25kg of juice, and add 1.5 times the total weight of medicinal materials for the second time water, decoct for 1.5 hours, take the juice, combine the decoction, filter, control the temperature of the filtrate at 60°C, concentrate to a thick paste with a relative density of 1.12 for later use, stir well, and dry at a low temperature of 1-5°C to obtain a dry soak Paste 2.5kg, add starch 375g, granulate, be pulverized into fine powder, pack into capsule, be pr...

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Abstract

The invention discloses a drug for treating elderly intractable insomnia and a preparation method of the drug. The drug is prepared by the following material medicines in parts by weight: 20-30 parts of radix salviae miltiorrhizae, 20-30 parts of Chinese angelica, 6-8 parts of coptidis rhizome, 15-20 parts of spina date seeds, 6-10 parts of cinnamons, 15-20 parts of white paeony roots, 10-12 parts of cortex lycii radicis, 10-15 parts of poria cocos, 6-10 parts of ligusticum wallichii, 15-20 parts of semen sojae praeparatum, 10-15 parts of radix ophiopogonis, 10-15 parts of beautiful sweetgum fruits, 20-30 parts of astragali radix, 15-20 parts of medicinal cyathula roots, 10-15 parts of lilies and 15-30 parts of honey-fried licorice roots. The drug disclosed by the invention can be prepared into capsules by the steps such as decocting, filtering, concentrating the filtrate, drying and the like. According to the drug disclosed by the invention, the etiology and pathogenesis of the elderly insomnia are analyzed clearly, the theories of the traditional Chinese medicine and the theories of modern Chinese medicine are combined to realize the organic combination of the theories, methods, prescriptions and drugs of the traditional Chinese medicine, so that the multiple medicines are applied in a combined manner, the curative effect is remarkable and the adverse reactions are avoided.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating intractable insomnia, in particular to a traditional Chinese medicine for treating senile intractable insomnia. Background technique [0002] With the rapid development of my country's economy, the pace of people's life is accelerating, and the number of patients with insomnia and neurasthenia is increasing rapidly. Chronic insomnia is common among community populations. With the aging population and changes in the spectrum of diseases, the incidence of insomnia has increased significantly. trend. Insufficient sleep and sleep disorders have become major diseases that seriously affect people's physical and mental health. According to the results of most epidemiological surveys at home and abroad, about 33% of people have experienced sleep disorders in various degrees every year, and 17% People are serious insomnia, and insomnia has had a strong impact on people's life, work and physica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P25/20
Inventor 韩多林屈秀明秦泊洋
Owner 韩多林
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