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Preparation method of tanshinone extract and water soluble substance thereof

A tanshinone extract and tanshinone technology are applied in the field of preparation of tanshinone extract and its water-soluble matter, and can solve the problems of poor solubility of tanshinone, low extraction rate of active components, complex extract components, etc., so as to improve clinical efficacy and improve drug stability. performance, shortening the extraction time

Active Publication Date: 2013-03-20
颜晓文 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the deficiency of preparing tanshinone in the prior art and the problem of poor solubility of tanshinone, the present invention provides an improved extraction process and solubility of tanshinone suitable for industrial production Preparation method of excellent water-soluble tanshinone
After many years of research, the inventor found unexpectedly that using the whole Chinese medicine Salvia miltiorrhiza directly to add ethanol to extract can overcome the problem that the extract components in the prior art are too complicated and the extraction rate of the corresponding active ingredients is low, and cutting can obtain different The extracts of active ingredients in proportion can achieve the effects of different pharmacological effects of tanshinone (cardiovascular or antibacterial and anti-inflammatory, etc.) and different clinical indications (coronary heart disease or anti-infection, etc.)

Method used

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  • Preparation method of tanshinone extract and water soluble substance thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 prepares tanshinone extract

[0039] sample 1

[0040] Take the whole material of salvia miltiorrhiza, add 80% ethanol in an amount 8 times the total weight of salvia miltiorrhiza, heat at a constant temperature, and extract under reflux at 80°C for 3 times for 1.5h. Combine the three extraction filtrates, concentrate under reduced pressure until there is no alcohol smell, wash the extract nine times with 8 times the amount of 90°C purified water, and dry at -0.08MPa at a temperature of 75°C to obtain the tanshinone extract.

[0041] sample 2

[0042] Take the whole material of salvia miltiorrhiza, add 85% ethanol in an amount 6 times the total weight of salvia miltiorrhiza, heat at a constant temperature of 75°C and extract under reflux for 3 times, each time for 0.5h. Combine the three extraction filtrates, concentrate under reduced pressure until there is no alcohol smell, wash the extract for 10 times with 9 times the amount of 90°C purified water, an...

Embodiment 2

[0073] Take the whole material of salvia miltiorrhiza and add 95% ethanol of 8 times the total weight of salvia miltiorrhiza, heat and reflux at a constant temperature of 75°C for extraction, reflux with 95% ethanol for 3 hours for the first time, and reflux with 6 times the amount of 92% ethanol for the second and third times. Reflux for 1.5h. Combine the filtrates extracted from 3 times, the concentrated performance has no alcohol smell, wash the extract 9 times with 8 times the amount of purified water at 90°C, and dry at -0.08MPa at a temperature of 75°C to obtain the tanshinone extract.

[0074] Among them, the content of tanshinone IIA is 13.5%, and that of cryptotanshinone is 10.2%.

[0075] Example 2

[0076] Take the whole material of salvia miltiorrhiza, add 95% ethanol in an amount 8 times the total weight of salvia miltiorrhiza for the first time, heat and reflux at a constant temperature, extract under reflux for 15 minutes, and add 91% ethanol for 1 hour under r...

Embodiment 3

[0079] Take the whole material of salvia miltiorrhiza, add 95% ethanol of 6 times the amount of the medicinal materials, keep the reflux for 3 hours, and take the filtrate; then extract the dregs twice with 90% ethanol of 6 times the amount of the medicinal materials, keep the reflux for 90 minutes, and combine 3 The extract was concentrated under reduced pressure to recover ethanol, the extract was evaporated to remove residual alcohol, washed 9 times with 8 times the amount of purified water at 90°C, and dried under reduced pressure at -0.08MPa at a drying temperature of 75°C to obtain a tanshinone extract .

[0080] Among them, the content of tanshinone IIA is 13.2%, and that of cryptotanshinone is 10.4%.

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Abstract

The invention provides a preparation method of a tanshinone extract and a water soluble substance thereof. The preparation method comprises the following steps of: extracting tanshinone by alcohol with the concentration being greater than or equal to 80%, wherein the tanshinone is segmented tanshinone or a complete material, and the mass ratio of the alcohol to the tanshinone is (5-20):1, heating and carrying out refluxing extraction for 2-5 times, combining and filtrating to obtain an extracting solution, wherein the extraction lasts for 0.25-3h every time; carrying out vacuum concentration on the extracting solution till an extract without the alcohol taste is obtained; and washing the extract by water for 5-12 times and drying under reduced pressure to obtain the tanshinone extract which contains 10.0-15.0% of tanshinone IIA and 8.0-11.0% of cryptotanshinone. The tanshinone extract prepared by the method provided by the invention has the advantages that the content of active substances is high, and the solubility of the water soluble substance of the tanshinone extract is good.

Description

【Technical field】 [0001] The invention relates to a traditional Chinese medicine extract, in particular to a preparation method of a tanshinone extract and a water-soluble product thereof. 【Background technique】 [0002] Tanshinone is an active ingredient extracted from the traditional Chinese medicine Salvia miltiorrhiza. It is a kind of diterpenoid quinone compound with o-quinone or p-quinone structure. Since the quinones are reduced to diphenols, which are then oxidized to quinones to induce electrons, the metabolites of tanshinone compounds in the body participate in various biochemical reactions in the body, and act as coenzymes for certain biochemical reactions. facilitate or interfere. The pharmacological effects of the extract of tanshinone focus on anti-oxidation, anti-virus, anti-bacterial and anti-inflammatory and cardiovascular and cerebrovascular, such as clinically used in the treatment of tonsillitis, otitis externa, mastitis, osteomyelitis, furuncle, carbunc...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K31/58A61K47/40A61P9/00A61P9/10A61P31/04A61P29/00
Inventor 颜晓文
Owner 颜晓文
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