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Method for specific continuous separation of micro-scale particles

A separation method and specific technology, applied in the field of chemistry, can solve the problem of insignificant molecular thermal movement, achieve high-throughput continuous adjustable multi-channel particle separation, overcome pipeline blockage, and achieve the best separation effect

Inactive Publication Date: 2015-02-18
XI'AN UNIVERSITY OF ARCHITECTURE AND TECHNOLOGY
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  • Application Information

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Problems solved by technology

However, for micron or slightly larger particles, the thermal / Brownian ratchet method is no longer applicable due to the insignificant thermal motion of the molecules

Method used

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  • Method for specific continuous separation of micro-scale particles
  • Method for specific continuous separation of micro-scale particles
  • Method for specific continuous separation of micro-scale particles

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Experimental program
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preparation example Construction

[0086] according to Figure 10 Finally, the ITO electrode is bonded to the silicon wafer (channel), and the structure of the dielectrophoretic microfluidic chip with specific and continuous separation of micro-scale particles is obtained. Figure 11 shown in Figure 11 , the leads are connected to the ITO electrodes through conductive tape.

[0087] By adjusting the flow rate and pulse frequency of the dielectrophoresis microfluidic chip for specific and continuous separation of micro-scale particles, the movement of 5 μm particles and 3 μm particles under the inclined electrodes was obtained, as shown in Fig. Figure 12 It can be seen that the particles of 5 μm always move along the direction of the electrode inclination, by Figure 12 It can be seen that the component perpendicular to the direction of the electrode and the DEP force cancel each other out of the two components of the Stokes force, and the other component promotes the movement of the 5 μm particles along the...

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Abstract

The invention discloses a method for specific continuous separation of micro-scale particles. The method can be used for realizing continuous adjustable multi-path separation of three types of different-size polystyrene microsphere mixtures by using a dielectrophoresis (DEP) microfluidic chip for specific continuous separation of micro-scale particles, and by regulating the flow rate of a fluid, the electric field intensity and the pulse frequency under the condition of continuous sampling. The three types of particles can move to the different spanwise positions of a channel since the three types of particles bear different intensities of DEP force and Stokes force; and the type of the extracted particle can be controlled at will by regulating control parameters. When an electric field parameter and a flow field parameter are matched, the medium-size 5mum particles can move on a flow channel always in an electrode tilting direction; the 3mum particles can move forwards substantially along the main flow direction; and the 10mum particles are influenced remarkably by the electric field and the flow field, and can move to the other side of the channel, so that the three types of particles are discharged from different outlets to obtain the 3mum, 5mum, and 10mum polystyrene particles, respectively.

Description

technical field [0001] The invention belongs to the enrichment and separation method and device in the chemical field, in particular to a specific continuous separation method for micro-scale particles, which is especially suitable for the specific separation of uncharged neutral particles. Background technique [0002] In most of the current applications, the Dielectrophoresis (DEP) force used only changes in space and does not change with time. It is a continuous force field in time, that is, continuous DEP. A variety of microdevices for particle separation and single particle / cell capture have been realized using this technology. The following will first briefly introduce the research on this kind of time-continuous DEP force field, and then explain the research status of another time-discontinuous DEP force field, pulse-type DEP. At the microscale, similar to other separation methods, particle separation based on continuous DEP force fields can generally be divided into...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D57/02
Inventor 刘顺东崔海航张鸿雁
Owner XI'AN UNIVERSITY OF ARCHITECTURE AND TECHNOLOGY
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