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A kind of heparin-loaded aneurysm treatment covered stent and preparation method thereof

A stent-graft and aneurysm technology are applied in the field of heparin-loaded aneurysm treatment stent-graft and its preparation, so as to avoid vascular endothelial hyperplasia, avoid vascular embolism, and facilitate adhesion.

Active Publication Date: 2015-08-12
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there is no report on the preparation of heparin-loaded nanofibers based on emulsion electrospinning technology, and finally the preparation of heparin-loaded stent grafts for the treatment of aneurysms

Method used

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  • A kind of heparin-loaded aneurysm treatment covered stent and preparation method thereof
  • A kind of heparin-loaded aneurysm treatment covered stent and preparation method thereof
  • A kind of heparin-loaded aneurysm treatment covered stent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] (1) attached figure 1 As shown in the construction device, the spinning nozzle is vertically placed directly above the high-speed rotating expandable aneurysm treatment bare metal stent, and the distance between the nozzle and the metal stent is 20 cm. The metal stent is connected with a rotating motor. Its diameter is about 2.7 mm and its length is about is 13mm.

[0030] (2) Weigh a certain mass of heparin sodium (Heparin, about 150 units / mg) and dissolve it in ultrapure water, and stir for 3 hours to obtain a heparin sodium aqueous solution with a concentration of 0.25 g / ml.

[0031] (3) Add 0.25 ml of sodium heparin solution and 0.01 ml of sorbitan oleate dropwise to 5 ml of dichloromethane at the same time, and stir for 8 hours to form a uniform sodium heparin solution-sorbitan oleate-di Methyl chloride emulsion.

[0032] (4) 0.4 g of poly(lactic acid polycaprolactone) copolymer (M w ≈300,000) is dissolved in the emulsion obtained in step (3), and the spinning s...

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Abstract

The invention relates to a heparin-loaded covered stent for treating arterial aneurysm and a preparation method thereof. The covered stent is characterized in that a covered layer is formed by heparin-loaded emulsion electrostatic spinning nanofibers, wherein the heparin-loaded nanofibers are provided with multi-core-layer structures. The preparation method of the covered stent comprises the following steps of arranging a preparation device, compounding a heparin sodium aqueous solution, preparing heparin sodium aqueous solution-sorbide oleate-dichloromethane emulsion, preparing an electrostatic spinning solution, and preparing a loading heparin covered stent. By adopting the covered stent, the problems which are common in treatment of small vessel diseases such as vascular endothelial proliferation and thrombosis can be effectively avoided; the heparin-loaded covered stent has a wide application prospect in the field of intravascular interventional treatment of small vessels arterial aneurysm; and the preparation method has the advantages that the preparation device is simple, procedure parameters are less, and the preparation process is stable.

Description

technical field [0001] The invention belongs to the field of covered stents for treating aneurysms and the preparation thereof, in particular to a heparin-loaded covered stent for treating aneurysms and a preparation method thereof. Background technique [0002] Aneurysm is a relatively common cardiovascular disease with a high mortality rate. The aneurysm cavity will compress peripheral nerves and organs, causing damage to adjacent tissues, often accompanied by the formation of wall thrombus, resulting in ischemia of remote tissues, and prone to rupture and bleeding of blood vessels due to trauma or increased internal pressure. The traditional treatment of aneurysm is mainly surgical operation, but the surgical treatment is traumatic and the postoperative healing is slow. If the blood vessel of the aneurysm innervates important organs, the blocking and repair surgery may cause dysfunction of important organs. With the development of treatment equipment and technology, endo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10
Inventor 莫秀梅吴瑃辰
Owner DONGHUA UNIV
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