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5% povidone-iodine solution for dairy cattle with strong stability and preparation process thereof

A technology of povidone iodine and strong stability, which is applied in the field of 5% povidone iodine solution with strong stability and its preparation for dairy cows, and can solve problems such as teats and teats are easy to dry and crack

Inactive Publication Date: 2013-03-06
HENAN KANGXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 3. Solve the problems of frostbite nipples and nipples that are easy to dry and crack when the temperature is too low

Method used

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  • 5% povidone-iodine solution for dairy cattle with strong stability and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0020] The present invention prepares the specific embodiment of 1000mL milk cow with strong stability 5% povidone-iodine disinfectant, and the weight ratio is as follows:

[0021] Povidone-iodine 50g

[0022] Ethanol 20g

[0023] Potassium iodate 20g

[0024] Glycerin 20g

[0025] Isopropanol 20g

[0026] Sodium Lauryl Sulfate 60g

[0027] Phosphate buffer 80g

[0028] Purified water 730g

[0029] Concrete preparation process is as follows:

[0030] (1) Melt povidone-iodine with an appropriate amount of pure water and ethanol completely, add sodium lauryl sulfate, stir evenly, and filter to obtain A solution;

[0031] (2) Prepare phosphate buffer solution, adjust its pH value to 5-6, and obtain B solution;

[0032] (3) Potassium iodate solution was prepared, and the potassium iodate solution was added to a mixture of an appropriate amount of glycerin and dipropanol to obtain C solution;

[0033] (4) Mix the process A, B, and C solutions together an...

Embodiment example 2

[0036] The present invention prepares the specific embodiment of 1000mL milk cow stability strong 5% povidone iodine disinfectant, and the weight ratio is as follows:

[0037] Povidone-iodine 50g

[0038] Ethanol 30g

[0039] Potassium iodate 25g

[0040] Glycerin 25g

[0041] Isopropanol 20g

[0042] Sodium Lauryl Sulfate 60g

[0043] Phosphate buffer 80g

[0044] Purified water 710g

[0045] Concrete preparation process is as follows:

[0046] (1) Melt povidone-iodine with an appropriate amount of pure water and ethanol completely, add sodium lauryl sulfate, stir evenly, and filter to obtain A solution;

[0047] (2) Prepare phosphate buffer solution, adjust its pH value to 5-6, and obtain B solution;

[0048] (3) Potassium iodate solution was prepared, and the potassium iodate solution was added to a mixture of an appropriate amount of glycerin and dipropanol to obtain C solution;

[0049] (4) Mix the process A, B, and C solutions together and stir...

Embodiment example 3

[0052] According to the production technique provided by the present invention, the 5% povidone-iodine solution of production, its stability inspection is to inspect by " Chinese Veterinary Pharmacopoeia " 2010 edition one, and inspection item comprises: character, pH value, identification, effective Iodine content, specifications. The standards are as follows: traits: reddish-brown liquid; PH value: 3.0-6.5; identification: (1) Take 1-5 drops of this product, add 10 mL of water and 1 drop of starch indicator, and it will appear blue-purple. (2) Take 10mL of this product, put it in a 50mL Erlenmeyer flask, cover the mouth of the bottle with a piece of filter paper moistened with starch indicator solution, leave it for 60s, and the blue color does not appear. Available iodine content: Titrated with sodium thiosulfate solution, the marked amount is in the range of 8.5% to 12.0%. The experimental design adopts two kinds of high temperature and low temperature. High temperature:...

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Abstract

The invention belongs to the technical field of medicine preparation, and particularly relates to a 5% povidone-iodine solution for dairy cattle with strong stability and a preparation process thereof. The 5% povidone-iodine solution for dairy cattle with strong stability is characterized by comprising the components by weight percentage as follows: 5% of povidone-iodine, 1-5% of cosolvent, 1-5% of stabilizer, 1-10% of protective agent, 1-5% of antifreezing agent, 5-10% of surfactant, 5-20% of phosphate buffer and purified water. The preparation process comprises the steps of: processing materials; mixing; activating; filtering; adjusting pH values; setting volume; packaging; and sealing. The 5% povidone-iodine solution for dairy cattle with strong stability is used before or after milking the cattle to prevent mastitis of the dairy cattle. Meanwhile, nipples are prevented from being frozen and cracked, and the stability of the povidone-iodine solution at high and low temperatures is guaranteed.

Description

technical field [0001] The invention belongs to the field of medicine preparation, in particular to a highly stable 5% povidone-iodine solution for dairy cows and a preparation process thereof. [0002] Background technique [0003] Povidone-iodine is recognized as a new type of high-efficiency, broad-spectrum, less irritating, non-toxic and side effects, no residue, and no drug resistance fungicide. It has a strong killing effect on Staphylococcus aureus, Pseudomonas aeruginosa, hepatitis B virus, HIV, Trichomonas vaginalis, spores, etc., and can almost kill common bacteria in clinical practice. But so far, because povidone iodine has multiple iodine forms and is volatile, under different pH values, the content of available iodine varies greatly, which affects its content and directly affects the therapeutic effect. The pH value of povidone-iodine solution is very unstable, and the range of decline is very large. At present, povidone-iodine is mostly newly formulated for...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/79A61K47/02A61K47/20A61P31/02
Inventor 常利君黄文华李晓翠
Owner HENAN KANGXING PHARMA
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