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Method for improving biodegradation rate of pure iron or iron alloy and application thereof

A biodegradable, ferroalloy technology, applied in medical science, prosthesis, etc., to achieve the effect of increasing the degradation rate and wide application range

Inactive Publication Date: 2013-02-06
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with pure iron, the degradation rate of these new degradable iron alloys has been improved to varying degrees, but there is still a large distance from the requirements of clinical use, and there is still a lot of room for improvement in the degradation rate of iron-based alloys.

Method used

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  • Method for improving biodegradation rate of pure iron or iron alloy and application thereof
  • Method for improving biodegradation rate of pure iron or iron alloy and application thereof
  • Method for improving biodegradation rate of pure iron or iron alloy and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Pure iron was selected as the experimental material, the pore cross section was circular, the pore size was 0.08mm, and the pore type was through hole; the pore distribution was according to figure 1 Design, the pore spacing is 0.5mm. Pores are prepared by corrosion pore creation.

[0030] The prepared sample and the blank control sample (pure iron sample without pore structure) were subjected to immersion weight loss experiment, and the experimental parameters were as follows: immersion solution: Hank’s simulated body fluid, experimental temperature: 37°C, immersion time: 30 days.

[0031] Calculate the degradation rate results: the degradation rate of the pure iron sample with pore structure is 0.029mm / year, which is 61.1% higher than that of the blank control sample (0.018mm / year).

Embodiment 2

[0033] Select Fe-30Mn-1C alloy as the experimental material. The pore cross section is circular, the pore size is 0.10mm, and the pore type is through hole; the pore distribution is according to figure 2design with a pore spacing of 1mm. Cutting and drilling with fiber laser.

[0034] The prepared sample and the blank control sample were subjected to soaking weight loss test, and the experimental parameters were as follows: soaking solution: 0.9% NaCl solution, experimental temperature: 37°C, soaking time: 15 days.

[0035] Calculate the degradation rate results: the degradation rate of the porous structure sample is 0.43mm / year, which is 40.0% higher than that of the blank control sample (0.31mm / year).

Embodiment 3

[0037] Fe-30Mn was selected as the experimental material, the pore cross section was narrow slit shape, the slit width was 0.10 mm, the slit length was 4 mm, and the pore type was through hole; the pore distribution was according to image 3 Design, the distance between the two nearest neighbors is 1mm. Holes are cut with a laser.

[0038] The prepared sample and the blank control sample were subjected to soaking weight loss test, and the experimental parameters were as follows: soaking solution: 0.9% NaCl solution, experimental temperature: 37°C, soaking time: 15 days.

[0039] Calculation of the degradation rate results: the degradation rate of the pore structure sample is 0.176mm / year, which is 51.7% higher than that of the blank control sample (0.116mm / year).

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Abstract

The invention aims to provide a method for improving the biodegradation rate of pure iron or iron alloy, which is characterized in that: pore structures are produced in the pure iron or iron alloy so that the degradation rate of the pure iron or iron alloy in the physiological environment is improved. Due to the adoption of the method, the problem that the degradation rate of the pure iron or iron alloy which develops as the biodegradable metal material is too low is solved. According to the principle of crevice corrosion, various types of pore structures are produced on the iron-based biodegradable material to achieve the purpose of improving the degradation rate of the material. Compared with the materials without the pore structures, the degradation rate of the iron-based biodegradable material is improved markedly, and the original biocompatibility is kept.

Description

technical field [0001] The invention relates to the technical field of biodegradable materials, and is particularly suitable for pure iron or iron alloy degradable cardiovascular stents, specifically a novel method for introducing a pore structure into existing biodegradable pure iron or iron alloys to increase the material degradation rate. Background technique [0002] After the existing metal medical devices are implanted into the human body, they generally need to be taken out by a second operation, which increases the risk of surgery and the pain and economic pressure of patients. However, once some metal medical devices are implanted in the human body, it is difficult to take them out again, and they remain permanently in the human body. The human body's rejection of foreign bodies requires patients to take related drugs for a long time, and the pain will accompany them for a lifetime. In addition, permanent metal implants have other disadvantages. Taking cardiovascu...

Claims

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Application Information

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IPC IPC(8): C22C1/08C22C33/00A61L27/04A61L27/58A61L27/56
Inventor 陆喜谭丽丽杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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