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Medical titanium with a trace element slow-release function or titanium alloy implant material as well as preparation method and application of same

A technology of trace elements and implant materials, used in metal material coating technology, electrolytic coatings, medical science and other directions, can solve problems such as implant surgery failure, improve the success rate, enhance the ability of bone healing and osseointegration, The effect of simple process conditions

Inactive Publication Date: 2013-02-06
WUHAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, during the clinical use of medical titanium implant materials, bacterial infection is one of the main reasons for the failure of implant surgery.

Method used

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  • Medical titanium with a trace element slow-release function or titanium alloy implant material as well as preparation method and application of same
  • Medical titanium with a trace element slow-release function or titanium alloy implant material as well as preparation method and application of same
  • Medical titanium with a trace element slow-release function or titanium alloy implant material as well as preparation method and application of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A medical titanium or titanium alloy implant material with the slow-release function of trace element Sr and a preparation method thereof. Put the titanium-containing metal sheet as an anode into the electrolyte for anodic oxidation, the anodic oxidation voltage is 40-60V, and the anodic oxidation time is 0.5-4 hours; then the anodized titanium-containing metal sheet is rinsed and dried at 100 Heat treatment at ~300℃ for 1~3 hours, after natural cooling, ultrasonic cleaning and drying, then place in 0.005~0.015 mol / L strontium hydroxide solution, hydrothermal reaction in a closed container at 100~200℃ for 0.5~ 3h, cool naturally, take it out, wash and dry, then heat treatment at 450-550°C for 1~3h, a kind of nanotube biological coating with trace element Sr slow-release function is obtained on the surface of titanium-containing metal sheet, which continuously releases trace elements Sr (such as Figure 7 shown), can promote cell proliferation and cell differentiation t...

Embodiment 2

[0049] A medical titanium or titanium alloy implant material with the slow-release function of trace element Sr and a preparation method thereof. Put the titanium-containing metal sheet as an anode into the electrolyte for anodic oxidation, the anodic oxidation voltage is 40-60V, and the anodic oxidation time is 0.5-4 hours; then the anodized titanium-containing metal sheet is rinsed and dried at 200 Heat treatment at ~500°C for 1~3 hours, after natural cooling, ultrasonic cleaning and drying, then place in 0.015~0.025 mol / L strontium hydroxide solution, hydrothermal reaction in a closed container at 150~300°C for 1~ 6h, cool naturally, take it out, wash and dry, heat treatment at 450-550°C for 1~3h, and get a kind of nanotube biological coating with trace element Sr slow release function on the surface of titanium-containing metal sheet, which continuously releases trace elements Sr can promote cell proliferation and cell differentiation to a certain extent, improve the biolo...

Embodiment 3

[0051] A medical titanium or titanium alloy implant material with the slow-release function of trace element Sr and a preparation method thereof. Put the titanium-containing metal sheet as an anode into the electrolyte for anodic oxidation, the anodic oxidation voltage is 20-40V, and the anodic oxidation time is 0.5-4 hours; then the anodized titanium-containing metal sheet is rinsed and dried at 100 Heat treatment at ~300℃ for 1~3 hours, after natural cooling, ultrasonic cleaning and drying, then place in 0.005~0.015 mol / L strontium hydroxide solution, hydrothermal reaction in a closed container at 100~200℃ for 0.5~ 3h, cool naturally, take it out, wash and dry, then heat treatment at 450-550°C for 1~3h, a kind of nanotube biological coating with trace element Sr slow-release function is obtained on the surface of titanium-containing metal sheet, which continuously releases trace elements Sr can promote cell proliferation and cell differentiation to a certain extent, improve ...

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Abstract

The invention relates to medical titanium with a trace element slow-release function or a titanium alloy implant material as well as a preparation method and an application of the medical titanium. The invention adopts the technical scheme that the preparation method comprises the following steps: putting a polished titanium-containing metal sheet into an electrolyte as an anode for anodic oxidation; flushing and drying the titanium-containing metal sheet subjected to anodic oxidation, carrying out heat treatment for 1-3 hours at a temperature of 100-500 DEG C, naturally cooling and ultrasonically cleaning and drying; and putting the dried titanium-containing metal sheet into one of or mixed solution of more than any two strontium hydroxide, strontium acetate, zinc acetate or magnesium acetate, carrying out hydrothermal reaction for 0.5-12 hours in a closed container at a temperature of 100-300 DEG C, naturally cooling, taking out, cleaning and drying, and carrying out heat treatment for 1-3 hours at a temperature of 450-550 DEG C to obtain the medical titanium with the trace element slow-release function or the titanium alloy implant material. The medical titanium or the titanium alloy implant material as well as the preparation method and the application thereof have the beneficial effects that the preparation method is simple and reliable, the loading quantity and the release amount of trace elements of the medical titanium in a nano tube are controllable, the medical titanium and the biological activity on the alloy surface can be better promoted, and the application prospect is good in the medical implant material.

Description

Technical field [0001] The invention is the field of nano -biological coating technology on the surface of medical titanium and titanium alloy.Specifically involved a medical titanium or titanium alloy implant material and its preparation methods and applications with a trace element mitigation function. technical background [0002] In recent years, as the population aging has accelerated, osteoporosis fractures have increased year by year. At the same time, bone marrow, osteoarthritis and work injuries, bone defects and fractures caused by traffic accidents have also increased year by year.Materials in clinical demand at a speed of 10-15%per year (K. A. Hing, Bone Repair in the Twenty-FIRST Century: Biology, Chemistic or Engineering, Phil. Trans. R. Soc. Lond. A 2004, 362, 362, 362, 362, 362, 362, 362, 362, 362, 362, 362, 362, 362, 362,2821-2850.).The far -reaching social influence and huge economic benefits of the institute in this field are obvious. [0003] 47, 49).Compared ...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/30C23C28/04C25D11/26
Inventor 霍开富陈荣生王海蓉张旭明付继江
Owner WUHAN UNIV OF SCI & TECH
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