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Veterinary albendazole suspension and preparation method thereof

A technology of albendazole and suspension, which is applied in the field of preparation of veterinary albendazole suspension, which can solve the problems of inaccurate dosage, inconvenient taking of livestock, and influence on deworming effect, so as to alleviate the pain of livestock , good redispersibility and reliable quality

Inactive Publication Date: 2013-02-06
QINGDAO VLAND BIOTECH INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most widely used albendazole preparation is its tablet. In animal husbandry, it is inconvenient for livestock to take it, and the administration operation is cumbersome, which may easily cause livestock vomiting, resulting in inaccurate dosage and affecting the deworming effect.

Method used

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  • Veterinary albendazole suspension and preparation method thereof
  • Veterinary albendazole suspension and preparation method thereof
  • Veterinary albendazole suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Dissolve 5g of tragacanth gum in 200ml of water for injection to make a glue for later use; add 50g of albendazole to 10g of glycerol to moisten, grind it fully into a paste, slowly add the tragacanth glue, and grind while adding; 1g of lemon Dissolve sodium benzoate and 1g of sodium benzoate with an appropriate amount of water for injection, add to the suspension, add the remaining water for injection to a total volume of 1000ml; under the action of a high-speed homogenizer, mechanically shear for 15 minutes; filter, pot, and sterilize at 100°C 30min, vested.

Embodiment 2

[0055] Dissolve 5g of tragacanth gum in 200ml of water for injection to make a glue for later use; add 50g of albendazole to 20g of glycerin to moisten, grind it fully into a paste, slowly add the tragacanth glue, and grind while adding; 1g of lemon Dissolve sodium benzoate and 1g of sodium benzoate with an appropriate amount of water for injection, add to the suspension, add the remaining water for injection to a total volume of 1000ml; under the action of a high-speed homogenizer, mechanically shear for 15 minutes; filter, pot, and sterilize at 100°C 30min, vested.

Embodiment 3

[0057] 50g of gum arabic was dissolved in 200ml of water for injection to prepare a mucilage for later use; 25g of albendazole was moistened with 10g of glycerol, and fully ground into a paste, then slowly added into the mucilage of arabic and ground while adding; 1g of sodium citrate and benzene Dissolve sodium formate with an appropriate amount of water for injection, add it to the suspension, add the remaining water for injection to a total volume of 1000ml; under the action of a high-speed homogenizer, mechanically shear for 15 minutes; filter, pot, and sterilize at 100°C for 30 minutes.

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Abstract

The invention discloses veterinary albendazole suspension and a preparation method thereof. The albendazole suspension comprises a main drug, a wetting agent, a suspending agent and a preservative. The albendazole suspension can be dosed through intramuscular injection, is convenient to operate, guarantees drug dosage, lightens livestock pains, and is exquisite in preparation process, controllable in quality, safe, reliable, convenient to use, low in cost and suitable to popularization and application in the breeding industry.

Description

technical field [0001] The present invention relates to a kind of veterinary preparation technology, specifically a kind of preparation method of veterinary albendazole suspension. Background technique [0002] Albendazole, also known as albendazole, belongs to the class of benzimidazoles, and its chemical name is 5-propylthio-1H-benzimidazole-2-methyl carbamate. It is a broad-spectrum, high-efficiency, low- Poisonous veterinary anthelmintics. Albendazole is rapidly metabolized into sulfone and sulfoxide in the body, mainly by inhibiting the absorption of glucose, leading to the depletion of glycogen in the insect body and inhibiting the generation of adenosine triphosphate by inhibiting the fumarate reductase system, preventing the development and survival of the insect body. Albendazole has a high-efficiency repellent effect on a variety of nematodes, and it also has a good repellent effect on certain trematodes, tapeworms and their larvae. [0003] Albendazole is an int...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/4184A61P33/00A61P33/10
Inventor 郝智慧冯培生贾德强刘元元王艳玲沈巍
Owner QINGDAO VLAND BIOTECH INC
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