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Novel nano-stent available for epithelial implantation and preparation method of novel nano-stent

A nano-scaffold, a new type of technology, applied in the field of nano-scaffolds to reduce complications, facilitate adhesion and proliferation, promote tracheal mucosa repair and clinical reconstruction of tracheal defects

Inactive Publication Date: 2013-01-30
SHANGHAI PULMONARY HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But so far, there is no report on the application of silk fibroin and PLGA in the reconstruction of tracheal defects at home and abroad.

Method used

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  • Novel nano-stent available for epithelial implantation and preparation method of novel nano-stent
  • Novel nano-stent available for epithelial implantation and preparation method of novel nano-stent
  • Novel nano-stent available for epithelial implantation and preparation method of novel nano-stent

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Embodiment Construction

[0033] Referring to the accompanying drawings, a novel nano-scaffold that can be used for epithelial implantation according to the present invention will be introduced and described in detail through specific embodiments, so as to better understand the present invention, but it should be understood that the following embodiments It does not limit the scope of the invention.

[0034] 1. Preparation of silk fibroin

[0035] Follow the steps below to prepare silk fibroin:

[0036] 1) 15gNaHCO 3 After adding to 3 liters of water and boiling, add 30 grams of dried silkworm cocoons, boil for 30 minutes, take out the cocoons, and add the above NaHCO 3 water solution, continue to boil, repeat 3 times;

[0037] 2) After rinsing the boiled silkworm cocoons with deionized water for 5-6 times, put the silkworm cocoons in a 45-degree oven and dry them (try to cut the silkworm cocoons into pieces and place them scattered to make them dry thoroughly);

[0038] 3) Put 10 grams of the drie...

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Abstract

The invention discloses a novel electro-spinning nano-stent available for tracheal epithelial implantation of a rat and a preparation method of the novel nano-stent, wherein the component materials comprise lactic acid-glycollic acid copolymer and silk fibroin in a mass ratio of (1-3):(7-9); and lactic acid-glycollic acid copolymer and silk fibroin are mixed to prepare a nanoscale reticular fiber plane stent. The novel nano-stent available for epithelial implantation provided by the invention is beneficial to the adhesion and proliferation of cells, can be used for repairing tracheal epithelium, alimentary canal epithelium, digestive gland acinus, catheter and the like, can be particularly used for repairing trachea defects, and provides meaningful references for promoting the repairing of tracheal mucosa and the clinical reconstruction of trachea defects, and reducing postoperative complications of trachea reconstruction.

Description

technical field [0001] The invention relates to a nano-stent, in particular to a novel nano-stent that can be used for epithelial planting and a preparation method thereof. Background technique [0002] At present, when the body has extensive damage to the trachea due to inflammation, trauma, tumors or other lesions, and a long section of the trachea is removed, it is necessary to repair the defective trachea. For a long time, the problem of repairing tracheal cartilage defects has puzzled clinicians. One-stage end-to-end anastomosis is only suitable for the repair of local defects. When the length of the defect exceeds 6.0 cm, serious complications such as anastomotic leakage are prone to occur due to high anastomotic tension. The rapid development of tissue engineering technology research has brought new hope to tracheal reconstruction, but since the beginning of 1994, there has been no breakthrough. It is still in the stage of experimentation and exploration, and there a...

Claims

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Application Information

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IPC IPC(8): A61L27/26
Inventor 郑卉陈昶高文
Owner SHANGHAI PULMONARY HOSPITAL
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