Applications of 5-(3,4-methylenedioxy phenyl)-2E,4E pentadienoic acid propylamine amide in preparation of neurological disease treatment products
A dioxyphenyl, disease technology, applied in nervous system diseases, drug combinations, active ingredients of heterocyclic compounds, etc., can solve even serious side effects and other problems
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Embodiment 1
[0019] Example 1: 5-(3,4-methylenedioxyphenyl)-2E, 4E pentadienoic acid n-propanamine amide has monoamine oxidase inhibitory activity
[0020] 1. Materials:
[0021] 1.1 Animals: Wisteria rats, provided by the Animal Center of the Academy of Military Medical Sciences, certificate number: SCXK-(Army) 2002-001.
[0022] 1.2 Drugs and reagents Piperine (purchased from Beijing Pharmaceutical Purchasing and Supply Station), the purity is 98%. Thin-layer chromatography silica gel H (chemically pure, purchased from Qingdao Ocean Chemical Co., Ltd.); column chromatography silica gel (reagent grade, 200-300 mesh, purchased from Qingdao Ocean Chemical Co., Ltd.); thin-layer chromatography silica gel prefabricated plate (purchased Yantai Institute of Chemical Industry); PBS phosphate buffer (purchased from Beijing Solarbio); MAO-A inhibitor clorgyline, MAO-B inhibitor selegiline, MAO enzyme reaction substrate kynuramine dihydrobromide, standard 4-hydroxy quinoline (purchased from sigma...
Embodiment 2
[0040] Example 2: Research on antidepressant activity of 5-(3,4-methylenedioxyphenyl)-2E, 4E pentadienoic acid n-propylamine amide
[0041] 1. Materials:
[0042] 1.1 Animals 120 SPF grade Kunming mice (18-22g), all male.
[0043] 1.2 Drugs and reagents Piperine (Beijing Pharmaceutical Purchasing and Supply Station), with a purity of 98%. DMEM / F12 (1:1) medium (Hyclone Company); thiazolium blue (Merck Company); desipramine (purchased from Sigma Company); corticosterone (Sigma Company); fetal bovine serum (Hangzhou Sijiqing Bioengineering Materials Co., Ltd.); PBS (Beijing Solarbio Company); dimethyl sulfoxide (Beijing Chemical Reagent Company, batch number 060730); thionyl chloride (Beijing Chemical Reagent Company); sulfuric acid (Beijing Chemical Reagent Company); hydrochloric acid (Beijing Chemical Reagent Company); Reagent Company); trypsin (Beijing Trypsin Amresco0458 subpackage); penicillin, streptomycin (North China Pharmaceutical Co., Ltd.). Potassium hydroxide (Bei...
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