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Povidone iodine ointment and preparation method thereof

A technology of povidone-iodine ointment and povidone-iodine ointment, applied in the direction of ointment delivery, pharmaceutical formulation, aerosol delivery, etc., which can solve the unfavorable large-scale production of povidone-iodine ointment and long preparation time of povidone-iodine ointment and other problems, to achieve the effect of facilitating large-scale process production, controlling the loss of iodine content, and the method is simple and easy.

Active Publication Date: 2014-03-26
武汉迪奥药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0025] For the deficiencies in the prior art, the object of the present invention is to provide a kind of povidone-iodine ointment and preparation method thereof of fully water-soluble matrix containing polyethylene glycol, this ointment can effectively solve the problem of povidone-iodine and povidone-iodine The compatibility of ethylene glycol, the preparation time of povidone-iodine ointment is too long, which is not conducive to large-scale production, and the stability of povidone-iodine ointment during production, preparation and storage

Method used

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  • Povidone iodine ointment and preparation method thereof
  • Povidone iodine ointment and preparation method thereof
  • Povidone iodine ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A kind of povidone iodine ointment, its component and consumption are as follows:

[0048] component name Dosage (kg) Mass percentage of components Povidone iodine 25 10% potassium iodate 0.25 0.1% polyethylene glycol-400 60 24% Polyethylene glycol-4000 50 20% Xylitol 37.5 15% Glycerol 50 20% Sodium dodecyl sulfate 5 2.0% purified water 22.25 8.9% total 250 100%

[0049] The preparation process step of the povidone-iodine ointment of above-mentioned formula is as follows:

[0050] (1) Put polyethylene glycol-400 and polyethylene glycol-4000 together in a container, heat at 78~82°C for 30 minutes to melt and stir evenly, and keep warm for later use;

[0051] (2) Take xylitol, add glycerin and stir for 15 minutes to dissolve it, then pour it into the container of the above step (1), stir at 78~82°C for 15 minutes, then continue to keep warm for later use;

...

Embodiment 2

[0057] A kind of povidone iodine ointment, its component and consumption are as follows:

[0058] component name Dosage (kg) Mass percentage of components Povidone iodine 25 10% potassium iodate 0.5 0.2%

[0059] polyethylene glycol-400 52.5 21% Polyethylene glycol-4000 65 26% Xylitol 25 10% Glycerol 45 18% Sodium dodecyl sulfate 1.25 0.5% purified water 35.75 14.3% total 250 100%

[0060] The preparation process step of the povidone-iodine ointment of above-mentioned formula is as follows:

[0061] (1) Put polyethylene glycol-400 and polyethylene glycol-4000 together in a container, heat at 78~82°C for 30 minutes to melt and stir evenly, and keep warm for later use;

[0062] (2) Take xylitol, add glycerin and stir for 15 minutes to dissolve it, then pour it into the container of the above step (1), stir at 78~82°C for 15 minutes, then continue to keep ...

Embodiment 3

[0068] A kind of povidone iodine ointment, its component and consumption are as follows:

[0069] component name Dosage (kg) Mass percentage of components Povidone iodine 25 10% potassium iodate 1 0.4% polyethylene glycol-400 50 20% Polyethylene glycol-4000 65 26% Sorbitol 25 10% Glycerol 45 18% Sodium dodecyl sulfate 1.5 0.6% purified water 37.5 15%

[0070] total 250 100%

[0071] The preparation process step of the povidone-iodine ointment of above-mentioned formula is as follows:

[0072] (1) Put polyethylene glycol-400 and polyethylene glycol-4000 together in a container, heat at 78~82°C for 30 minutes to melt and stir evenly, and keep warm for later use;

[0073] (2) Take sorbitol, add glycerin and stir for 15 minutes to dissolve it, then pour it into the container of the above step (1), stir at 78~82°C for 15 minutes, then continue to keep warm f...

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Abstract

The invention relates to the technical fields of medicinal preparations and preparation methods thereof and particularly discloses a formula of povidone iodine ointment of full water-soluble matrix and a preparation method thereof. The povidone iodine ointment consists of the following components in percentage by weight: 10 percent of povidone iodine, 0.1 to 0.5 percent of potassium iodate, 20 to 31 percent of polyethylene glycol-400, 20 to 30 percent of polyethylene glycol-4000, 5 to 15 percent of xylitol or sorbitol serving as a matrix protecting agent, 15 to 20 percent of glycerol, 0.5 to 2.0 percent of sodium dodecyl sulfate, and 7.5 to 15 percent of purified water. By using unique protective methods and means, the technical problem of low stability in preparation and storage processes of the ointment after the povidone iodine and the water-soluble polyethylene glycol matrix are mixed is solved, the povidone iodine ointment with good performance advantages is prepared, the manufacturing time is greatly shortened, the working efficiency is improved, and the povidone iodine ointment is suitable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations and preparation methods thereof, in particular to a prescription of povidone-iodine ointment with a fully water-soluble matrix and a preparation method thereof. Background technique [0002] Povidone-iodine is a broad-spectrum and highly effective disinfectant and antiseptic, which can kill a variety of bacteria, spores, viruses, fungi, etc. Its mechanism of action is that after povidone-iodine contacts the wound or affected area, it can depolymerize and release iodine to play a bactericidal effect. Povidone-iodine is less irritating to tissues and is very suitable for the treatment of skin and mucous membrane infections. Clinically, it is often used in the treatment of burns, scalds, trauma infections, candida vulvovaginosis, bacterial vaginosis and mixed infectious vaginitis, and can also be used to treat hemorrhoids. "Chinese Pharmacopoeia" 2010 Edition (Part II) contains ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/18A61K9/06A61K47/34A61P17/02A61P15/02A61K31/79A61K47/10
Inventor 程汉强甘远鄂胡盛利金杰吴克红
Owner 武汉迪奥药业有限公司
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