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Receptor compound for detecting CN- by colorimetry-fluorescence two channels, synthesis thereof and application thereof

A compound, dual-channel technology, applied in the field of anion detection, can solve the problems of difficult synthesis, complex structure, restricted application and so on

Inactive Publication Date: 2013-01-09
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cyanide colorimetric or fluorescent receptors reported in the literature are often complex in structure and difficult to synthesize, which severely restricts the application of such methods.

Method used

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  • Receptor compound for detecting CN- by colorimetry-fluorescence two channels, synthesis thereof and application thereof
  • Receptor compound for detecting CN- by colorimetry-fluorescence two channels, synthesis thereof and application thereof
  • Receptor compound for detecting CN- by colorimetry-fluorescence two channels, synthesis thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Receptor synthesis

[0044] (1) Synthesis of intermediate 5-(4-nitrophenyl)furan-2-carbaldehyde: Mix 4.2 grams of p-nitroaniline, 8 mL of concentrated hydrochloric acid and 16 mL of water in a 100 mL round bottom flask, and slowly heat to reflux to The p-nitroaniline is completely dissolved to obtain aniline solution; after the dissolution is complete, place the round-bottomed flask in an ice bath (0-5°C), and at the same time accelerate stirring to precipitate very small crystals. Weigh 6g NaNO 2 Dissolve it in 9mL of water, slowly add it dropwise into the aniline solution with a constant pressure funnel, stir and react for 20 minutes after dropping, and filter with suction; Water, stir under ice bath (0~5°C), dissolve 0.8g copper chloride in 3mL water, slowly add it dropwise, remove the ice bath after dripping, continue to react at room temperature for 8 hours, a brick red precipitate forms , suction filtration, and recrystallization from ethanol to obtain the in...

Embodiment 2

[0051] 1, the synthesis of intermediate: with embodiment 1.

[0052] 2. Synthesis of receptors: Add 0.33g (1.5mmol) of intermediate 5-(4-nitrophenyl)furan-2-carbaldehyde, 0.08g (1.2mmol) propanedinitrile and 20mL of distilled water into a 50mL reaction bottle , stirred under reflux at 75°C for 3h, cooled and filtered with suction to obtain a yellow solid, which was recrystallized from ethanol to obtain the product —— 2-cyano-3-(5-(4-nitrophenyl)-2-furyl)acrylonitrile.

[0053] Yield: 68.6%: the characterization data of synthetic product is the same as embodiment 1.

[0054] 3. CN - Preparation and detection of detection test paper: same as embodiment 1.

Embodiment 3

[0056] 1, the synthesis of intermediate: with embodiment 1.

[0057] 2. Synthesis of receptors: Add 0.33g (1.5mmol) of intermediate 5-(4-nitrophenyl)furan-2-carbaldehyde, 0.12g (1.8mmol) propanedinitrile and 20mL of distilled water into a 50mL reaction bottle , stirred under reflux at 60°C for 4h, cooled and filtered with suction to obtain a yellow solid, which was recrystallized from ethanol to obtain the product —— 2-cyano-3-(5-(4-nitrophenyl)-2-furyl)acrylonitrile.

[0058] Yield: 65.8%. The characterization data of the synthetic product is the same as in Example 1.

[0059] 3. CN - Preparation and detection of detection test paper: same as embodiment 1.

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Abstract

The invention provides a receptor compound--2-cyanogroup-3-(5-(4-nitrobenzophenone)-2-furyl) acrylonitrile for detecting CN- by colorimetry-fluorescence two channels. The recognition effect of the receptor compound to nine anions such as F-, Cl-, Br-, I-, Ac-, H2PO4-, HSO4-, ClO4-, Cn-and the like is researched by the colorimetric method, the ultraviolet-visible absorption spectroscopy and the fluorescent spectrometry. The result shows that the receptor compound can independently select the colorimetry-fluorescence two channels in DMSO (dimethylsulfoxide)-H2O to identify the cyanide ion, and is very high in the detection sensitivity of CN-, wherein the lowest detection limit can reach to 1*10<-8> mol. L<-1>. Furthermore, the invention further prepares a receptor-based cyanogen detection test paper, so that the cyanide ion in the DMSO-H2O can be conveniently and quickly detected by means of colorimetry-fluorescence.

Description

technical field [0001] The invention belongs to the technical field of anion detection and relates to a method for detecting anion CN - receptors, especially involving a colorimetric-fluorescence dual-channel detection CN - The receptor compound——2-cyano-3-(5-(4-nitrophenyl)-2-furyl)acrylonitrile; the present invention also relates to the synthesis of the receptor compound and its detection of anion CN - in the application. Background technique [0002] Cyanide is very easily absorbed by the human body, and can enter the human body through the mouth, respiratory tract or skin. When cyanide enters the stomach, under the dissociation of gastric acid, it can be immediately hydrolyzed into hydrogen cyanide and absorbed. After this substance enters the blood circulation, the Fe of cytochrome oxidase in the blood 3+ Combining with cyanide, it produces cyanide ferricytochrome oxidase, which loses the ability to transfer electrons, interrupts the respiratory chain, and suffocate...

Claims

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Application Information

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IPC IPC(8): C07D307/54G01N21/64G01N21/78
Inventor 林奇符永鹏张有明魏太保陈佩朱鑫
Owner NORTHWEST NORMAL UNIVERSITY
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