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Functional wound dressing capable of accelerating wound healing and preparation method thereof

A wound dressing and wound healing technology, which is applied in the direction of conjugated synthetic polymer artificial filament, medical science, absorbent pads, etc., can solve the problems that have not been reported in research and development, and achieve the purpose of avoiding wound adhesion, preventing the growth of new tissue, and accelerating The effect of wound healing

Inactive Publication Date: 2013-01-09
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Electrical stimulation has been used in the fields of promoting fracture repair and nerve regeneration, treating osteoporosis, chronic ulcers, etc., but the research and development of applying it to trauma dressings has not been reported yet

Method used

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  • Functional wound dressing capable of accelerating wound healing and preparation method thereof
  • Functional wound dressing capable of accelerating wound healing and preparation method thereof
  • Functional wound dressing capable of accelerating wound healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of PU electrospun membrane

[0033] (1) Mix THF and DMF in equal volumes to prepare a THF / DMF mixed solvent;

[0034] (2) Dissolve PU in the THF / DMF mixed solvent prepared in step (1), stir at room temperature until completely dissolved, and obtain PU spinning solution; wherein, the mass volume ratio of solute to solvent in PU spinning solution is 12 %;

[0035] (3) Electrospin the PU spinning solution prepared in step (2), set the flow rate of the syringe pump to 0.8~1.0 ml / h, and the output voltage of the DC high voltage generator to 12~18kV, adjust the distance between the needle and the receiving plate The distance is 15~20 cm;

[0036] (4) By controlling the time and moving the receiving plate, the PU electrospun membrane was prepared with a thickness of 150-250 μm.

Embodiment 2

[0037] Example 2 Preparation of PVDF electrospun membrane

[0038] (1) Mix THF and DMF in equal volumes to prepare a THF / DMF mixed solvent;

[0039] (2) Dissolve PVDF in the THF / DMF mixed solvent prepared in step (1), stir at room temperature until completely dissolved, and obtain PVDF spinning solution; wherein, the mass volume ratio of solute to solvent in PVDF spinning solution is 12 %;

[0040] (3) Electrospin the PVDF spinning solution prepared in step (2), set the flow rate of the syringe pump to 0.8~1.0 ml / h, and the output voltage of the DC high voltage generator to 12~18kV, and adjust the distance between the needle and the receiving plate. The distance is 15~20 cm;

[0041] (4) By controlling the time and moving the receiving plate, the PVDF electrospun membrane was prepared with a thickness of 150-250 μm.

Embodiment 3

[0042] Example 3 Preparation of PU / PVDF electrospun membrane

[0043] (1) Mix THF and DMF in equal volumes to prepare a THF / DMF mixed solvent;

[0044] (2) Dissolve PU and PVDF in the THF / DMF mixed solvent prepared in step (1), and stir at room temperature until completely dissolved to obtain PU spinning solution and PVDF spinning solution; among them, PU spinning solution and PVDF The mass volume ratio of solute and solvent in the spinning solution is 12%;

[0045] (3) Mix the PU spinning solution and PVDF spinning solution prepared in step (2) according to the volume ratio of 1:3~3:1, stir evenly at room temperature, and prepare PU / PVDF mixed spinning with different proportions. silk liquid;

[0046] (4) Electrospin the PU / PVDF mixed spinning solution with different proportions prepared in step (3), set the flow rate of the syringe pump to 0.8~1.0 ml / h, and the output voltage of the DC high voltage generator to 12~18kV, adjust The distance between the needle and the recei...

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Abstract

The invention relates to a functional wound dressing capable of accelerating wound healing and a preparation method thereof. The functional wound dressing is a polyurethane (PU) / polyvinylidene fluoride (PVDF) electric spinning membrane which is made of PU and PVDF in a mass ratio of 1:3-3:1, the functional wound dressing is prepared by using a method of electrostatic spinning, and the thickness of the PU / PVDF electric spinning membrane is 150-250 mum. The functional wound dressing can use electrical stimulatory effects produced by piezoelectric polymer PVDF to accelerate wound healing, has the advantages of being good in biocompatibility, simple and convenient to prepare, low in cost and the like, and is wide in market development prospects.

Description

technical field [0001] The invention relates to a dressing product used in the field of wound repair and a preparation method thereof, belonging to medical polymer materials. Background technique [0002] Wound dressings are medical materials that can temporarily protect burns, ulcers, wounds and other wounds, prevent pollution, and promote healing. Using wound dressings is one of the effective means of wound treatment. With the accelerated pace of modern life and the increasing demand for medical care, the demand for wound dressings is also increasing year by year. At present, the market demand for wound dressing products in China is huge. According to the research of Beijing Huatongren Commercial Information Co., Ltd. (ACMR), the market demand for wound dressings in China reached about 40 billion yuan in 2010. The dressings that are currently on the market or under development can be roughly divided into several categories according to different materials: traditional dre...

Claims

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Application Information

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IPC IPC(8): A61L15/26D01F8/16D01F8/10
Inventor 郭洪峰应希张家平
Owner ARMY MEDICAL UNIV
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