Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of Zhilining

A technology for relieving dysentery and extraction, applied in the field of preparation of zhiluning, which can solve the problems of backwardness, many impurities, and affecting clinical application

Inactive Publication Date: 2012-12-26
NANJING ZHENGLIANG MEDICAL TECH
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Zhili Ning. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affecting the clinical application of this product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take Andrographis paniculata 1000g, Sophora flavescens 250g, Muxiang 250g, add Muxiang to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; take Andrographis paniculata and Sophora flavescens, crush them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 400W, and the extraction time is 2 time, 4 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave Extract, set aside; mix the above supercritical extract and microwave ex...

Embodiment 2

[0026] Take Andrographis paniculata 1000g, Sophora flavescens 250g, Muxiang 250g, add Muxiang to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for later use; take Andrographis paniculata and Sophora flavescens, crush them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction time is 2 time, 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave Extract, set aside; mix the above supercritical extract and microwa...

Embodiment 3

[0029] Take Andrographis paniculata 1000g, Sophora flavescens 250g, Muxiang 250g, add Muxiang to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for later use; take Andrographis paniculata and Sophora flavescens, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction time is 2 time, 6 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry, and obtain microwave Extract, set aside; mix the above supercritical extract and micr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of Zhilining. 1000g of common andrographis herb, 250g of radix sophorae flavescentis and 250g of rosa banksiae are used as bulk drugs. The Zhilining is prepared by adopting supercritical extraction and microwave extraction. Therefore, the content of matrine is greatly enhanced.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method of Zhiluning. Background technique [0002] Zhili Ning is recorded in the standard WS3-B-0215-90 of the Ministry of Health. It is made of 1000g of Andrographis paniculata, 250g of Sophora flavescens, and 250g of Muxiang as raw materials. It can clear away heat and dampness, promote qi and relieve pain. It is used for enteritis and dysentery, manifested as abdominal pain and diarrhea, diarrhea with thick blood, scorching anus, and tenesmus. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Zhili Ning. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , Seriously affecting the clinical application of this produ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K9/20A61P1/12
CPCY02A50/30
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com