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Use of artemisia annua and artemisia annua industrial-extraction residues as raw materials for caffeoylquinic acid preparation

A technology for caffeoylquinic acid and Artemisia annua is applied in the application field of preparing caffeoylquinic acid raw materials, and can solve the problems of industrial separation and the like

Inactive Publication Date: 2012-12-12
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In fact Artemisia annua contains not only artemisinin, but also caffeoylquinic acid (Jian Han, Min Ye, Xue Qiao, Man Xu, Bao Rong Wang, De-An Guo. Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry. 2008, (47): 516-525), but this literature only identified caffeic acid quinic acids in the methanol extract substance, it was not quantified nor was the extraction explored

Method used

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  • Use of artemisia annua and artemisia annua industrial-extraction residues as raw materials for caffeoylquinic acid preparation
  • Use of artemisia annua and artemisia annua industrial-extraction residues as raw materials for caffeoylquinic acid preparation
  • Use of artemisia annua and artemisia annua industrial-extraction residues as raw materials for caffeoylquinic acid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 100g of the industrial extraction residue of Artemisia annua after extracting artemisinin with petroleum ether, add it into a solution with pH=1.0, n-butanol:water=9:1 at a solid-to-liquid ratio of 1:5 (w / w), and ultrasonically Leaching under action for 10 hours, after solid-liquid separation, the extract containing caffeoylquinic acid was obtained, and detected by high performance liquid chromatography, wherein the species of caffeoylquinic acid is shown in figure 1 .

[0021] 3.5g of caffeoylquinic acid with a purity of 61% was obtained by liquid-liquid extraction, and then 1.5g of caffeoylquinic acid with a purity of 94% was obtained through chromatography column separation and purification. Detected by liquid chromatography-mass spectrometry, 5-0 The mass spectrum (MS) of monocaffeoylquinic acid and the mass spectrum (MS) of 3,5-dicaffeoylquinic acid are shown in figure 2 and image 3 shown.

Embodiment 2

[0023] Take 100 g of industrial extraction residue of Artemisia annua after extracting artemisinin with a mixture of petroleum ether, chloroform and toluene, add it to the aqueous solution with pH=7.0 at a solid-to-liquid ratio of 1:60 (w / w), and extract in countercurrent for 9 hours. After solid-liquid separation, an extract containing caffeoylquinic acid was obtained, and 3.8 g of caffeoylquinic acid with a purity of 55% was obtained through liquid-liquid extraction, and then 1.6 g of caffeoylquinic acid with a purity of 92% was obtained through chromatography column separation and purification Nicotinic acid.

Embodiment 3

[0025] Take 100g of the Artemisia annua raw material, add it into the solution of pH=4.0 ethanol:water=5:1 according to the solid-liquid ratio of 1:10 (w / w), extract under the action of ultrasound for 5 hours, and obtain the coffee-containing The extract of caffeoylquinic acid was separated by liquid-liquid extraction to obtain 6.8 g of caffeoylquinic acid with a purity of 60%, and then separated and purified by a chromatographic column to obtain 3.7 g of caffeoylquinic acid with a purity of 94%.

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Abstract

The invention discloses a novel use of artemisia annua and provides a novel raw material source for caffeoylquinic acid preparation. The use provided by the invention has the advantages that limitation of artemisia annua development and utilization are overcome; comprehensive and effective utilization of an artemisia annua resource is realized; and artemisia annua industrial-extraction residues are changed into things of value so that large economic benefits, social benefits and environmental benefits are obtained.

Description

technical field [0001] The invention relates to a new application of Artemisia annua. Specifically, it is the application of Artemisia annua as a raw material for preparing caffeoylquinic acid. It effectively solves the current situation that the total caffeoylquinic acid contained in Artemisia annua is wasted in the current traditional production process, and Artemisia annua is only used to produce artemisinin, and provides a new source of raw materials for the production of total caffeoylquinic acid. Background technique [0002] Artemisia annua is a plant of Compositae Artemisia annua L The dry aerial part of . has the effects of clearing away heat and detoxifying, antimalarial and so on. Artemisinin is the active ingredient extracted from Artemisia annua, and it is the only new antimalarial drug internationally recognized in my country. [0003] Artemisia annua is rich in resources in my country, but the current industrial utilization of Artemisia annua is only a prod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/732C07C67/48
Inventor 陈育如张伟娜王建芬张怡斐
Owner NANJING NORMAL UNIVERSITY
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