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New application of fragrant sarcococca herb total alkaloid

A technology of total alkaloids and drugs, which is applied in the field of new application of total alkaloids of sanliang silver, can solve the problems of no pathogenesis and no AD treatment.

Inactive Publication Date: 2012-12-05
GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In 1907, German scholar Alois Alzheimer reported the clinical manifestations and pathological changes of AD for the first time. After continuous and in-depth research and exploration by countless researchers, no pathogenic mechanism can be found to explain AD definitively, nor a specific drug. Treat AD

Method used

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  • New application of fragrant sarcococca herb total alkaloid
  • New application of fragrant sarcococca herb total alkaloid
  • New application of fragrant sarcococca herb total alkaloid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0204] Process: Take 100g of Sanliang silver total alkaloids, mix it with 40g of starch, put it into capsules, and make 1000 capsules.

[0205] The total alkaloids of sanliang silver are prepared in this way: take sanliang silver, crush it into a coarse powder, and extract it with 95% ethanol under reflux for 3 times, each time for 3 hours, combine the extracts, concentrate to obtain an extract, add distilled water to dissolve the extract, and use chloroform Extracted 5 times, the chloroform extract was concentrated under reduced pressure to obtain the extract, that is to say.

[0206] Usage and dosage: take orally, 3 times a day, each time the dosage is 30mg based on the total alkaloids of Sanliang silver.

[0207] Functions and indications: acetylcholinesterase inhibitor; it can also be used to treat senile dementia, improve memory, and delay the decline of intelligence in patients.

Embodiment 2

[0209] Process: Take three liang silver total alkaloids, add water for injection to dissolve and fill in the corresponding container, sterilize by autoclaving at 115°C for 30 minutes, after cooling, filter with suction, dilute the filtrate with water for injection, filter with vertical melting filter ball, pour Sealed, sterilized by autoclaving at 115°C for 30 minutes, and prepared as an injection.

[0210] Sanliang silver total alkaloids are commercially available.

[0211] Usage and dosage: intramuscular injection, intravenous injection or intravenous drip, the daily dosage is 10mg based on the total alkaloids of Sanliang silver.

[0212] Functions and indications: used to treat senile dementia, improve memory, and delay the decline of intelligence in patients.

Embodiment 3

[0214] Process: take the total alkaloids of Sanliang silver, add water for injection to dissolve, add 2% mannitol, dry, and prepare freeze-dried powder for injection.

[0215]The total alkaloids of sanliang silver are prepared in this way: take sanliang silver, crush it into a coarse powder, extract it with 70% ethanol under reflux for 5 hours, combine the extracts, concentrate to obtain an extract, add distilled water to dissolve the extract, and extract 6 times with chloroform , The chloroform extract was concentrated under reduced pressure to obtain the extract, that is, too.

[0216] Usage and dosage: intramuscular injection, intravenous injection or intravenous drip, the daily dosage is 20mg based on the total alkaloids of Sanliang silver.

[0217] Functions and indications: acetylcholinesterase inhibitors.

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Abstract

The invention provides new application of fragrant sarcococca herb total alkaloid, and particularly relates to application of the fragrant sarcococca herb total alkaloid as an acetylcholinesterase inhibitor. The fragrant sarcococca herb total alkaloid can also be used for preventing or treating senile dementia, has an obvious effect and has development and utilization value.

Description

technical field [0001] The invention relates to a new application of the total alkaloids of Sanliang silver, in particular to the application of the total alkaloids of Sanliang silver as an acetylcholinesterase inhibitor and in the preparation of medicines for preventing or treating senile dementia. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a progressive neurodegenerative disease with insidious onset, gradual memory loss, cognitive impairment, behavioral abnormalities, and social disorders as the main clinical manifestations. . Senile plaques (SP) formed by the aggregation of β-amyloid protein (Aβ) outside the cells, neurofibrillary tangles (NFTs) formed by abnormal phosphorylation of tau protein in the cells, and nerve cells And decreased number of synapses are the main pathological features. According to statistics, there are more than 17 million senile dementia patients in the world, and there are more than 5 million in my...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P25/28
Inventor 杜江许建阳刘冬何康邹顺
Owner GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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