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Application of pachysamine/pachysandrine G

A technology of chlorpyrifosamine and diethylamine, which is applied in the fields of medical preparations containing active ingredients, steroids, organic chemistry, etc., can solve the problems of no AD treatment and no pathogenesis found.

Inactive Publication Date: 2014-04-30
GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In 1907, German scholar Alois Alzheimer reported the clinical manifestations and pathological changes of AD for the first time. After continuous and in-depth research and exploration by countless researchers, no pathogenic mechanism can be found to explain AD definitively, nor a specific drug. Treat AD

Method used

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  • Application of pachysamine/pachysandrine G
  • Application of pachysamine/pachysandrine G
  • Application of pachysamine/pachysandrine G

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0205] Process: Take 100g of phylloxamine G, mix it with 40g of starch, put it into capsules, and make 1000 capsules.

[0206] The preparation of Phosphatamine base G is as follows: take three taels of silver, crush it into a coarse powder, and extract it three times with 95% ethanol under reflux, each time for 3 hours, combine the extracts, concentrate to obtain an extract, dissolve the extract with distilled water, and extract with chloroform 5 times, the chloroform extract was concentrated under reduced pressure to obtain the extract, and the extract was mixed with silica gel for column chromatography separation, and petroleum ether-acetone-diethylamine 100:1:1, 100:5:1, 100:10: 1, 100:20:1, 100:50:1, 100:100:1 gradient elution, get 6 parts; take the second part, put it on a silica gel column, use petroleum ether-diethylammonia 100:1, 100: 3. Gradient elution at 100:5, 100:10, wherein the 100:3 fraction was eluted with petroleum ether: diethylammonia 100:1, and the eluate w...

Embodiment 2

[0210] Process: Take rich grass amine base G, add water for injection to dissolve and potting in the corresponding container, sterilize by autoclaving at 115°C for 30 minutes, after cooling, filter with suction, dilute the filtrate with water for injection, filter with vertical melting filter ball, potting , 115 ° C and then autoclaved for 30 minutes, prepared as an injection.

[0211] Phylloxamine G is commercially available.

[0212] Usage and dosage: Intramuscular injection, intravenous injection or intravenous drip, the daily dosage is 2 mg based on the calculation of phylactine G.

[0213] Functions and Indications: It is used to treat senile dementia, improve memory, and prevent the decline of intelligence in patients.

Embodiment 3

[0215] Process: Take pachyramine base G, dissolve it in water for injection, add 2% mannitol, dry it, and prepare it into a freeze-dried powder for injection.

[0216] The preparation method of rich grass amine base G is the same as embodiment 1.

[0217] Usage and dosage: Intramuscular injection, intravenous injection or intravenous drip, the daily dosage is 1 mg based on the calculation of phytosanline G.

[0218] Functions and indications: acetylcholinesterase inhibitors.

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Abstract

The invention provides an application of pachysamine / pachysandrine G. Specifically, the pachysamine / pachysandrine G can be applied as an acetylcholinesterase inhibitor, also can be used for preventing or treating senile dementia, and has obvious effects and development and utilization values.

Description

technical field [0001] The present invention relates to the application of rich chloramine G, in particular to the application of rich chloramine G as an acetylcholinesterase inhibitor and in the preparation of medicaments for preventing or treating senile dementia. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a progressive neurodegenerative disease with insidious onset, gradual memory loss, cognitive impairment, behavioral abnormalities, and social disorders as the main clinical manifestations. . Senile plaques (SP) formed by the aggregation of β-amyloid protein (Aβ) outside the cells, neurofibrillary tangles (NFTs) formed by abnormal phosphorylation of tau protein in the cells, and nerve cells And decreased number of synapses are the main pathological features. According to statistics, there are more than 17 million senile dementia patients in the world, and there are more than 5 million in my country, accounting for a quarter...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/57A61P25/28C07J41/00
Inventor 杜江许建阳刘冬邹顺何康
Owner GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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