Application of pachysamine/pachysandrine G
A technology of chlorpyrifosamine and diethylamine, which is applied in the fields of medical preparations containing active ingredients, steroids, organic chemistry, etc., can solve the problems of no AD treatment and no pathogenesis found.
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Embodiment 1
[0205] Process: Take 100g of phylloxamine G, mix it with 40g of starch, put it into capsules, and make 1000 capsules.
[0206] The preparation of Phosphatamine base G is as follows: take three taels of silver, crush it into a coarse powder, and extract it three times with 95% ethanol under reflux, each time for 3 hours, combine the extracts, concentrate to obtain an extract, dissolve the extract with distilled water, and extract with chloroform 5 times, the chloroform extract was concentrated under reduced pressure to obtain the extract, and the extract was mixed with silica gel for column chromatography separation, and petroleum ether-acetone-diethylamine 100:1:1, 100:5:1, 100:10: 1, 100:20:1, 100:50:1, 100:100:1 gradient elution, get 6 parts; take the second part, put it on a silica gel column, use petroleum ether-diethylammonia 100:1, 100: 3. Gradient elution at 100:5, 100:10, wherein the 100:3 fraction was eluted with petroleum ether: diethylammonia 100:1, and the eluate w...
Embodiment 2
[0210] Process: Take rich grass amine base G, add water for injection to dissolve and potting in the corresponding container, sterilize by autoclaving at 115°C for 30 minutes, after cooling, filter with suction, dilute the filtrate with water for injection, filter with vertical melting filter ball, potting , 115 ° C and then autoclaved for 30 minutes, prepared as an injection.
[0211] Phylloxamine G is commercially available.
[0212] Usage and dosage: Intramuscular injection, intravenous injection or intravenous drip, the daily dosage is 2 mg based on the calculation of phylactine G.
[0213] Functions and Indications: It is used to treat senile dementia, improve memory, and prevent the decline of intelligence in patients.
Embodiment 3
[0215] Process: Take pachyramine base G, dissolve it in water for injection, add 2% mannitol, dry it, and prepare it into a freeze-dried powder for injection.
[0216] The preparation method of rich grass amine base G is the same as embodiment 1.
[0217] Usage and dosage: Intramuscular injection, intravenous injection or intravenous drip, the daily dosage is 1 mg based on the calculation of phytosanline G.
[0218] Functions and indications: acetylcholinesterase inhibitors.
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