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Application of sarcococca vegans alkaline D

A technology of wild fan flower and flower alkali, applied in the application field of Hainan wild fan flower alkali D, can solve the problems of no AD treatment and no pathogenesis found

Inactive Publication Date: 2012-11-14
GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In 1907, German scholar Alois Alzheimer reported the clinical manifestations and pathological changes of AD for the first time. After continuous and in-depth research and exploration by countless researchers, no pathogenic mechanism can be found to explain AD definitively, nor a specific drug. Treat AD

Method used

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  • Application of sarcococca vegans alkaline D
  • Application of sarcococca vegans alkaline D
  • Application of sarcococca vegans alkaline D

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0206] Process: Take 100g of Hainan phyllophylline D, mix it with 40g of starch, put it into capsules, and make 1000 capsules.

[0207] Hainan wildflower alkali D is prepared in this way: take three taels of silver, crush it into a coarse powder, and reflux extract it with 95% ethanol three times, each time for 3 hours, combine the extracts, concentrate to obtain an extract, add distilled water to dissolve the extract, and use chloroform Extracted 5 times, the chloroform extract was concentrated under reduced pressure to obtain the extract, the extract was mixed with silica gel for column chromatography separation, and petroleum ether-acetone-diethylamine 100:1:1, 100:5:1, 100:10 :1, 100:20:1, 100:50:1, 100:100:1 gradient elution, 6 fractions were obtained; the first fraction was put on a silica gel column and eluted with petroleum ether-diethylammonia 100:1, The eluent was recrystallized from methanol to obtain .

[0208] Usage and dosage: take orally, 3 times a day, each do...

Embodiment 2

[0211] Process: Take Hainan wildflower base D, add water for injection to dissolve and seal in the corresponding container, sterilize by autoclaving at 115°C for 30 minutes, after cooling, filter with suction, dilute the filtrate with water for injection, filter with vertical melting filter ball, pour Sealed, sterilized by autoclaving at 115°C for 30 minutes, and prepared as an injection.

[0212] Hainan phyllophylline D is commercially available.

[0213] Usage and dosage: intramuscular injection, intravenous injection or intravenous infusion, the daily dosage is 2 mg based on Hainan phyllophylline D.

[0214] Functions and Indications: It is used to treat senile dementia, improve memory, and prevent the decline of intelligence in patients.

Embodiment 3

[0216] Process: Take Hainan phyllopine D, dissolve it in water for injection, add 2% mannitol, dry it, and prepare it into a freeze-dried powder for injection.

[0217] The preparation method of Hainan phyllopine D is the same as in Example 1.

[0218] Usage and dosage: Intramuscular injection, intravenous injection or intravenous infusion, the daily dosage is 3 mg based on Hainan phyllophylline D.

[0219] Functions and indications: acetylcholinesterase inhibitors.

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PUM

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Abstract

The invention provides an application of sarcococca vegans alkaline D. Particularly, the sarcococca vegans alkaline D can serve as an acetylcholinesterase inhibitor, can be used for preventing or treating senile dementia and has an obvious effect and development and utilization value.

Description

technical field [0001] The present invention relates to the use of Hainan phylloline D, in particular to the use of Hainan phylloline D as an acetylcholinesterase inhibitor and in the preparation of medicaments for preventing or treating senile dementia. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a progressive neurodegenerative disease with insidious onset, gradual memory loss, cognitive impairment, behavioral abnormalities, and social disorders as the main clinical manifestations. . Senile plaques (SP) formed by the aggregation of β-amyloid protein (Aβ) outside the cells, neurofibrillary tangles (NFTs) formed by abnormal phosphorylation of tau protein in the cells, and nerve cells And decreased number of synapses are the main pathological features. According to statistics, there are more than 17 million senile dementia patients in the world, and there are more than 5 million in my country, accounting for a quarter of the worl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61P25/28C07J41/00
Inventor 杜江何康刘冬邹顺
Owner GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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