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New use of donepezil hydrochloride in preparation of drugs for treating amyotrophic lateral sclerosis

A technology for donepezil hydrochloride and lateral sclerosis, which can be used in drug combinations, active ingredients of heterocyclic compounds, neurological diseases, etc., can solve the problems of ALS patients that have not been proved effective.

Inactive Publication Date: 2016-07-13
彭福华
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Problems solved by technology

(2) Other drugs: In animal experiments, although several drugs have shown certain curative effects in the treatment of ALS animal models, such as creatine, high-dose vitamin E, coenzyme Q10, lithium carbonate, ciliary neurotrophic factor, Insulin-like somatotropin, lamotrigine, etc., but none of them proved to be effective in clinical studies on ALS patients
It can be seen that there are currently no effective drugs for the treatment of motor neuron disease

Method used

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Embodiment Construction

[0008] Case one,

[0009] A 50-year-old male patient with "left upper limb weakness for 5 years, slurred speech and progressive limb weakness for 2 years"

[0010] The patient developed left upper limb weakness 5 years ago without obvious inducement, showing that the upper arm could not be lifted, and the left hand could hold objects. The patient was given oral drug treatment in the local hospital, but the symptoms did not improve significantly. After that, the slurred speech gradually worsened, and the weakness of both lower limbs occurred, and he could not walk. He went to the hospital for a nerve conduction examination more than 20 days ago, and it was indicated: "The motor branches of the bilateral median nerve, ulnar nerve, tibial nerve, and common peroneal nerve are involved, and the sensory branch is generally normal. "; electromyographic examination showed "neurogenic changes"; now come to our hospital for further diagnosis and treatment. Since the onset, the mind is ...

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Abstract

The invention discloses a new use of donepezil hydrochloride for preparing drugs for treating amyotrophic lateral sclerosis, and belongs to a cholinesterase inhibitor. The invention aims to study preparation of drugs for treating motor neuron disease. The new use is characterized in that patients orally take donepezil hydrochloride. Before motoneurons of the patients with amyotrophic lateral sclerosis are dead, the cholinergic functions are reduced, and terminally ill patients with amyotrophic lateral sclerosis have the cholinergic functions of brains and spinal cords further reduced along with motoneuron loss. Donepezil hydrochloride can inhibit hydrolytic action of postsynaptic membrane acetylcholinesterase on acetylcholine transmitter substances, increases the acetylcholine concentration so as to increase the cholinergic neuron conduction activity, and is an effective method for improving cholinergic system functions.

Description

technical field [0001] A new application of donepezil hydrochloride in the preparation of medicines for treating amyotrophic lateral sclerosis belongs to a cholinesterase inhibitor. Background technique [0002] Donepezil is a second-generation selective acetylcholinesterase inhibitor, its chemical name is: donepezil hydrochloride. This medicine is suitable for the treatment of amyotrophic lateral sclerosis. This drug is mainly used for the treatment of mild and moderate Alzheimer's disease, vascular dementia and mild cognitive impairment after stroke. Due to its reversibility, relative specificity, long-acting and other characteristics, donepezil can be used in combination with various preparations to improve the curative effect. Dopezil has higher selectivity and specificity to central cholinesterase, improves the cognitive ability and clinical comprehensive function of patients with mild to moderate Alzheimer's disease, and has less adverse reactions, so it is a good T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445A61P25/02
Inventor 彭福华
Owner 彭福华
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