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Preparation method of water-soluble rare earth luminous nanocrystallines with functionalized surfaces

A technology of surface functionalization and rare earth luminescence, which is applied in chemical instruments and methods, luminescent materials, dyeing polymer organic compound treatment, etc., can solve the problems of difficult degradation and toxicity, and achieve low cost, uniform size and good stability Effect

Inactive Publication Date: 2012-11-21
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, polymers are widely used in the functionalization of inorganic particles, such as polyacrylic acid PAA, etc., but they are usually difficult to degrade and have certain toxicity
Polyaspartic acid is a completely biodegradable material. Polyaspartic acid and its derivatives are mainly used to prepare pH-sensitive hydrogels, or to synthesize amphiphilic block polymers to coat materials, etc. Polyday There are few reports on the direct synthesis of water-soluble rare earth nanoparticles using aspartic acid

Method used

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  • Preparation method of water-soluble rare earth luminous nanocrystallines with functionalized surfaces
  • Preparation method of water-soluble rare earth luminous nanocrystallines with functionalized surfaces
  • Preparation method of water-soluble rare earth luminous nanocrystallines with functionalized surfaces

Examples

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Effect test

Embodiment 1

[0023] 1. Weigh 0.045mol lanthanum nitrate hexahydrate, 0.0025mol cerium nitrate hexahydrate and 0.0025mol terbium nitrate hexahydrate respectively with an electronic balance, and make 100ml uniform solution with deionized water, and the total rare earth concentration is 0.5mol / L;

[0024] 2. Add 0.1g of polysuccinimide with a molecular weight of 6000 to a 50ml reaction kettle, add 15ml of water, and then dropwise add 1ml of 1.0mol / L sodium hydroxide aqueous solution, and after fully stirring, a red transparent polyaspartame is obtained acid solution;

[0025] 3. Put 0.126g of sodium fluoride in 15ml of water and stir thoroughly to obtain a clear and transparent solution;

[0026] 4. Add the clear and transparent solution obtained in step 3 to the solution obtained in step 2, and stir for 10 minutes; then add 2ml of the rare earth nitrate mixed solution prepared in step 1, and continue stirring for 15 minutes to fully chelate it to obtain a milky white glue Liquid;

[0027] ...

Embodiment 2

[0030] 1. Weigh 0.0490mol lanthanum nitrate hexahydrate and 0.0010mol europium nitrate hexahydrate respectively with an electronic balance, and make 100ml uniform solution with deionized water, the total rare earth concentration is 0.5mol / L, and the molar ratio between rare earth elements The ratio is La:Eu=98:2;

[0031] 2. Add 0.1g of polysuccinimide with a molecular weight of 6000 to a 50ml reaction kettle, add 15ml of water, and then dropwise add 1ml of 1.0mol / L sodium hydroxide aqueous solution, and after fully stirring, a red transparent solution is obtained;

[0032] 3. Put 0.12g of ammonium metavanadate in 15ml of water, add 2mmol of sodium hydroxide, and stir thoroughly to obtain a clear and transparent solution;

[0033] 4. Add the clear and transparent solution obtained in step 3 to the solution obtained in step 2, and stir for 10 minutes; then add 2ml of the rare earth nitrate mixed solution prepared in step 1, and continue stirring for 15 minutes to fully chelate ...

Embodiment 3

[0037] 1. Weigh 0.0490mol lanthanum nitrate hexahydrate and 0.0010mol europium nitrate hexahydrate respectively with an electronic balance, and make 100ml uniform solution with deionized water, the total rare earth concentration is 0.5mol / L, and the molar ratio between rare earth elements The ratio is La:Eu=98:2;

[0038] 2. Add 0.1g of polysuccinimide with a molecular weight of 6000 to a 50ml reaction kettle, add 15ml of water, and then dropwise add 1ml of 1.0mol / L sodium hydroxide aqueous solution, and after fully stirring, a red transparent solution is obtained;

[0039] 3. Put 0.12g of ammonium metavanadate in 15ml of water, add 3mmol of sodium hydroxide, and stir thoroughly to obtain a clear and transparent solution;

[0040]4. Add the clear and transparent solution obtained in step 3 to the solution obtained in step 2, and stir for 10 minutes; then add 2ml of the rare earth nitrate mixed solution prepared in step 1, and continue stirring for 15 minutes to fully chelate i...

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Abstract

The invention discloses a preparation method of water-soluble rare earth luminous nanocrystallines with functionalized surfaces, and belongs to the technical field of preparation of inorganic nanomaterials. The preparation method includes utilizing a pot of water to realize thermal reaction; and modifying water-soluble biopolymers to surfaces of rare earth particles during forming of crystal nucleus of rare earth materials so as to obtain water-soluble rare earth nanomaterials. The preparation method is low-cost, easy and convenient, environment-friendly and universal and is applicable to direct surface functionalization of rare earth inorganic materials in different shapes and different particle sizes. The rare earth nanocrystallines prepared by the method are uniform in size, high in crystallinity and fluorescence intensity and good in dispersibility, can be stably preserved in water for five months at least, have rich active groups on the surfaces and have good biocompatibility and a good coupling property, and accordingly are significant in applications of biofluorescence imaging, medical diagnosis and the like.

Description

technical field [0001] The invention belongs to the technical field of preparation of inorganic nanometer materials, in particular to a preparation method of surface-functionalized water-soluble rare earth luminous nanocrystals. technical background [0002] As a bioluminescent probe, rare earth-doped nanoluminescent materials have unique advantages, such as excellent light and chemical stability, long lifetime, and strong resistance to photobleaching. Compared with organic dyes and quantum dots, it has a wide range of applications in the fields of fluorescence imaging and biological detection. Among them LaVO 4 、LaF 3 It is a more commonly used luminescent matrix material. However, the premise of its biological application is high luminous efficiency, certain water solubility, and active groups on the surface (such as -COOH, -NH 2 Or -SH, etc.), can be coupled with biological functional molecules. [0003] At present, rare earth luminescent materials with better morpho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09C1/00C09C3/10C09C3/06C09K11/85C09K11/82
Inventor 汪乐余王涣杰
Owner BEIJING UNIV OF CHEM TECH
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