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Water phase preparation method for chain platinum nanosphere by taking octreotide acetate as template

A technology for preparing octreotide acetate and aqueous phase, which is applied in the field of nanomaterials, can solve the problems of inability to control the morphology of reaction products well, cannot be formed, and limit the preparation of nanomaterials, and achieves a regular morphology, small size, and easy reaction control. Effect

Inactive Publication Date: 2013-12-18
YANSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods generally cannot control the morphology of the reaction product well, and cannot form
Therefore, the preparation of nanomaterials is limited

Method used

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  • Water phase preparation method for chain platinum nanosphere by taking octreotide acetate as template
  • Water phase preparation method for chain platinum nanosphere by taking octreotide acetate as template
  • Water phase preparation method for chain platinum nanosphere by taking octreotide acetate as template

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 0.5 mg of octreotide acetate (Shanghai Taishi Biotechnology Co., Ltd.), dissolve it in 1 mL of deionized water, and prepare 0.5 mM octreotide acetate; adjust its pH to 2 with hydrochloric acid (Yongfei Chemical Factory); take the above acetic acid Add 200 μL of octreotide solution, add 5 mM platinum tetrachloride solution (Tianjin Chemical Reagent Factory); put the above prepared solution into a constant temperature shaker in a water bath, incubate at 130 rpm., 13 °C for 26 h, and gradually 25 mM reducing agent dimethylborane (Beijing Zhongsheng Huateng Technology Co., Ltd.) was added dropwise for reduction, so that it changed from light yellow to gray black, and octreotide acetate-chain platinum nanospheres were obtained.

[0024] Such as figure 1 with figure 2 As shown, it can be seen that the diameter of platinum particles is 2.5±0.5 nm, and octreotide acetate is a regular ellipsoid with a diameter of about 55 nm, uniform in size, and can form a streptosphere ...

Embodiment 2

[0028] Take 0.5 mg of octreotide acetate, dissolve it in 1 mL of deionized water, configure 0.5 mM octreotide acetate, adjust its pH to 8 with sodium hydroxide (Tianjin Fengchuan Chemical Reagent Technology Co., Ltd.); take the above octreotide acetate solution 200 μL, add 5 mM platinum tetrachloride solution; put the above-prepared solution into a constant temperature shaker in a water bath, incubate at 100 rpm., 25°C for 20 h, then add 25 mM reducing agent dimethyl boron dropwise The alkane is reduced to make it change from light yellow to gray black, and octreotide acetate-chain platinum nanospheres are obtained.

[0029] Such as Image 6 with Figure 7 As shown, different pH can change the diameter of octreotide acetate-chain platinum nanospheres, indicating that the morphology of octreotide acetate is controllable. Under alkaline conditions, the diameter of octreotide acetate-chain platinum nanospheres is about 25 nm, and the platinum particles are slightly agglomerated...

Embodiment 3

[0031] Take 0.8 mg of octreotide acetate and dissolve it in 1 mL of deionized water to prepare 0.8 mM octreotide acetate, and adjust its pH to 3 with hydrochloric acid; take 200 μL of the above octreotide acetate solution and add 6.4 mM platinum tetrachloride solution; Put the above-prepared solution into a constant temperature shaker in a water bath, incubate at 170 rpm., 18°C ​​for 24 h, then add 36 mM reducing agent dimethylborane dropwise for reduction, making it change from light yellow to gray The black line means that octreotide acetate-chain platinum nanospheres are obtained.

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Abstract

The invention discloses a water phase preparation method for chain platinum nanosphere by taking octreotide acetate as a template. The method mainly comprises the following steps: regulating octreotide acetate into acid solution with a pH of 2 to 3 using hydrochloric acid or alkaline solution with a pH of 8 to 10 using sodium hydroxide; adding platinum tetrachloride solution into the obtained solution at a mole ratio of 1:8-12, placing the mixed solution into a water-bathing constant temperature vibrator, and incubating the mixed solution for 20-26 h at the temperature of 13-25 DEG C at a speed of 10-200 rpm; and dropwise adding reducing agent dimethylborane into the incubated solution to turn the light yellow color of the incubated solution into black gray color, that is, obtaining an octreotide acetate-chain platinum nanosphere, wherein the mole ratio of dimethylborane to octreotide acetate is 1:45-55. The water phase preparation method has the advantages of simple process, low cost, availability, easiness in reaction control, high yield and the like.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a method for preparing chain-like platinum nanospheres. Background technique [0002] Nanomaterials refer to ultrafine particles with a particle size between 1 and 100 nm, which are in the transition zone where atomic clusters and macroscopic objects alternate. With the reduction of the material dimension and the reduction of the structural feature size (≤100 nm), the surface effect, quantum size effect, quantum tunneling effect, and Coulomb blocking effect of the material will become more and more obvious, so that the material presents a special Therefore, the preparation of nanomaterials has become one of the hotspots of scientific research in the world. Nano-platinum particles loaded on the support as a heterogeneous catalyst have been widely used in the chemical industry for catalytic hydrogenation, dehydrogenation, methane conversion and hydrogen isotope steam-gas cat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B82Y40/00
Inventor 高大威赵晓宁高发明李娜周景
Owner YANSHAN UNIV
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