Application of dlk1 in the diagnosis and prognosis of liver cancer
A liver cancer prognosis and application technology, applied in the field of oncology and diagnosis, can solve the lack of serum markers and other problems
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0105] Serum DLK1 protein concentration was significantly elevated in patients with liver cancer
[0106] In this example, the concentration of DLK1 in the serum of 400 cases of liver cancer patients and 88 cases of healthy control group was detected by ELISA method.
[0107] The results showed that the concentration of DLK1 in HCC serum was 2378.6±337.5pg / ml (mean±SD); the concentration of DLK1 in healthy control group serum was 685.4±38.9pg / ml (mean±SD); The concentration of DLK1 was significantly higher than that of the healthy control group (P figure 2 ).
[0108] Therefore, if the concentration of DLK1 in the serum of the detected subject is ≥1000 pg / ml (more preferably ≥2000 pg / ml), it indicates that the probability of the subject suffering from liver cancer is significantly higher than that of the normal population.
Embodiment 2
[0110] The relationship between serum DLK1 concentration and various clinical indicators
[0111] In order to further explore the relationship between serum DLK1 concentration and various clinical indicators, according to the ROC curve ( image 3 ) set the cut-off value (threshold) of DLK1 as 890pg / ml, its sensitivity and specificity were 33.2% and 75.0% respectively, and the positive rate was about 22% (29 / 132). The clinicopathological indicators included in the statistical analysis mainly include patient gender, age, serum alpha-fetoprotein, hepatitis B virus surface antigen, tumor size, Edmondson histological grade, intrahepatic metastasis and associated liver cirrhosis.
[0112] Statistical analysis results showed that serum DLK1 concentration was closely related to Edmondson histological grade and tumor size in patients with liver cancer (Table 1).
[0113] Table 1. Correlation analysis between serum DLK1 concentration and clinicopathological indicators in patients with ...
Embodiment 3
[0117] Serum DLK1 concentration is closely related to survival of patients with liver cancer
[0118] In this example, the survival of DLK1-positive and DLK1-negative liver cancer patients was analyzed with 890 pg / ml as the cut-off value.
[0119] The results showed that the survival time of DLK1-negative HCC patients was significantly longer than that of DLK1-positive patients ( Figure 4 ) (P=0.033). Among them, there were 91 patients with DLK1-negative liver cancer, with a median survival time of 902 days; and 27 patients with DLK1-positive liver cancer, with a median survival period of 596 days).
[0120] The above results indicated that the serum DLK1 concentration is suitable as a serum marker for the detection and judgment of the prognosis of liver cancer.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com