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Application and preparation method of medicament and functional food for treating brain paralysis

A functional food and drug technology, applied in food preparation, application, drug combination, etc., can solve the problems of long course of treatment, high cost, lack of specific therapeutic drugs, etc., and achieve the effect of improving cognitive level and effective support

Inactive Publication Date: 2012-11-14
SHANXI ZHONGYUANWEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the incidence of cerebral palsy is very serious, which not only seriously affects the normal life of patients, but also brings a heavy burden to the family and society. Traditional Chinese and Western medicine lack special therapeutic drugs, and clinical treatment is mostly symptomatic, and the course of treatment is long. The cost is expensive, and the desired therapeutic effect cannot be achieved. There is no drug approved for the treatment of this disease with a single Chinese medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take fresh earthworm, wash it, grind it into a homogenate with a colloid mill, and after ultrasonic treatment for 10-20 minutes, stir evenly, adjust the temperature at 0°C to 15°C, and centrifuge at a low temperature and high speed at a speed of 14000-24000 / min, and take the supernatant Pre-freeze in a vacuum freeze dryer at 0°C to -60°C for 1-4 hours, adjust the temperature of the condenser to -20°C to -80°C, and vacuum to 5-100Pa, turn on the heating and dry the product slowly for 12- 36 hours, get the earthworm extract, take 30-70 parts of earthworm extract according to the weight ratio, 30-70 parts of auxiliary materials, add appropriate amount of common medicines such as starch, microcrystalline cellulose, silicon dioxide, sodium carboxymethyl starch, etc. Using excipients, make granules by conventional preparation methods, compress into 0.4g tablets, and wrap enteric film coating.

Embodiment 2

[0025] Take fresh earthworm, wash it, grind it into a homogenate with a colloid mill, and after ultrasonic treatment for 10-30 minutes, stir evenly, adjust the temperature at 0°C to 15°C, and centrifuge at a low temperature and high speed at a speed of 14000-22000 / min, and take the supernatant , put in a vacuum freeze dryer to freeze-dry to obtain the earthworm extract, take 70-90 parts of the earthworm extract by weight ratio, 10-30 parts of auxiliary materials, add appropriate amount of auxiliary materials such as starch and silicon dioxide, and prepare with conventional preparation methods Granulate, fill enteric-coated capsules, and make 0.25g / granule enteric-coated capsules.

Embodiment 3

[0027] Take fresh earthworm, wash it, grind it into a homogenate with a colloid mill, and after ultrasonic treatment for 10-30 minutes, stir evenly, adjust the temperature at 0°C to 15°C, and centrifuge at a low temperature and high speed at a speed of 14000-22000 / min, and take the supernatant , freeze-dried in a vacuum freeze dryer to obtain the earthworm extract, take 30-50 parts of the earthworm extract by weight ratio, 50-70 parts of auxiliary materials, add appropriate amount of lactose, β-cyclodextrin, carboxymethyl cellulose Sodium, microcrystalline cellulose and other auxiliary materials are made into 2g / bag granules by conventional preparation methods.

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Abstract

The invention relates to an application and a preparation method of a medicament and functional food for treating brain paralysis. The preparation method is characterized by comprising the steps of cleaning the selected fresh lumbricus, milling the fresh lumbricus to be homogenate by a colloid mill, conducting ultrasonic processing for 10-30 minutes, then stirring uniformly, adjusting the temperature to be 0 DEG C-20 DEG C, conducting high-speed centrifugation at the rotating speed of 10000-30000turns / min, arranging a liquid supernatant into a vacuum freeze dryer, precooling for 1-4 hours at 0 DEG C-minus 60 DEG C, then adjusting the temperature of a condenser to be minus 20 DEG C-minus 80 DEG C, with the vacuum degree being 5-100Pa, starting to heat, and heating and drying the product slowly for 12-36 hours to obtain a lumbricus extract, selecting 10-90 parts of lumbricus extract and 10-90 parts of auxiliary material according to the weight ratio, and adding various general auxiliary materials needed for preparing different dosage form to prepare the general dosage form of any pharmaceutics according to a general Chinese herba preparation. The general dosage form is applied to prepare the drug or the functional food for treating the brain paralysis.

Description

technical field [0001] The invention relates to a medicine or a functional food, in particular to an application of a traditional Chinese medicine or a functional food for treating cerebral palsy (cerebral palsy, CP) and a preparation method thereof. Background technique [0002] Cerebral palsy is defined as a group of persistent syndromes of movement and postural developmental disturbances resulting in limited mobility due to non-progressive damage or developmental defects in the brain of a developing fetus or infant. Accompanied by sensory, cognitive, communication, perception and / or behavioral disorders, as well as epilepsy and secondary skeletal muscle problems, the incidence of cerebral palsy in developed countries is about 2 / 1000 of newborns on average, and the incidence rate in my country is 1 / 1000 1.5 to 5 / 1000, accounting for the first place in the number of pediatric neurology and genetic counseling outpatients. [0003] At present, the incidence of cerebral palsy i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P25/00A23L1/29A23L33/00A61K35/62
Inventor 钟志孟
Owner SHANXI ZHONGYUANWEI PHARMA
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