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Preparation method of novel anticoccidial drug decoquinate

A technology of decoquinate and anticoccidia, which is applied in the field of preparation of anticoccidial drug decoquinate, and achieves the effects of simple operation, high total yield and short reaction time

Inactive Publication Date: 2012-11-07
QINGDAO VLAND BIOTECH INC +2
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  • Abstract
  • Description
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Problems solved by technology

The synthesis method adopts complete ethoxylation followed by nitration, which can avoid oxidation or polymerization of phenolic hydroxyl groups in the nitration process, but after complete ethoxylation, nitration may have two or more products, and in the subsequent selection In the process of permanent deethoxylation, the generation of impurities cannot be avoided

Method used

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  • Preparation method of novel anticoccidial drug decoquinate
  • Preparation method of novel anticoccidial drug decoquinate
  • Preparation method of novel anticoccidial drug decoquinate

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Experimental program
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Embodiment Construction

[0046] 1) Preparation of 3-ethoxy-4-hydroxyazobenzene (compound 1):

[0047] Add 28ml of concentrated hydrochloric acid to the reaction flask, add 35ml of water, cool, add 10.5g of aniline under stirring, the solution is cooled to 0-5°C, white crystals appear in the system, and another 8.4g of sodium nitrite is weighed and dissolved in 25ml of water, and added dropwise For the above-mentioned aniline solution, keep the temperature of the system at 0-5° C., after the dropwise addition is completed, stir and react for 10-15 minutes. 10.5 g of sodium carbonate and 4.8 g of sodium acetate were added to obtain a diazonium salt solution.

[0048] In addition, dissolve 13.8g of o-hydroxyphenylethyl ether in 400ml of ethanol, cool to 0-5°C, and add the above-mentioned diazonium salt solution dropwise under stirring, at a slow rate. After addition, react for 3 hours, concentrate to remove ethanol, add 200ml of water to the residue, extract with chloroform, combine organic phases, wash...

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Abstract

The invention relates to the technical field of veterinary drug preparation and provides a preparation method of novel anticoccidial drug decoquinate. The preparation method includes steps that pyrocatechol monoethyl ether is used as a raw material, and the decoquinate is obtained through diazotization coupling reaction, decyl oxidation, reduction reaction, condensation reaction and cyclization reaction. The preparation method of the novel anticoccidial drug decoquinate is good in selectivity, high in operability, small in pollution, high in yield and suitable for large-scale production. Total yield of a target compound is about 45%.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparation, and mainly relates to a preparation method of anticoccidial drug decoquinate. Background technique [0002] Decoquinate (Decoquinate) is a quinoline anticoccidial drug, which was first developed and synthesized by the British May-Baker company in the 1960s. Its broad-spectrum anticoccidial activity makes it a good choice for the prevention and treatment of chicken coccidiosis. A quinoline drug with good effect can be used to prevent and treat coccidiosis caused by chicken tenderness, poisoning, heap type, giant size, displacement and Eimeria brucei. In addition, decoquinate can also alleviate and treat animal diarrhea caused by Cryptosporidium. Since Eli Lilly and Company of the United States first marketed decoquinate in China, it has aroused widespread concern in the domestic veterinary drug industry. Ideal for drug rotation, kills coccidia, promotes growth, improves color...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D215/56
Inventor 郝智慧姚德勇贾德强林扬沈巍王艳玲
Owner QINGDAO VLAND BIOTECH INC
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