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Moisture protection method of traditional Chinese medicine extract and solid preparation obtained by traditional Chinese medicine

A technology for solid preparations and extracts, applied in the field of solid preparations of traditional Chinese medicine, can solve the problems of low moisture-proof efficiency and large dosage of auxiliary materials

Active Publication Date: 2012-10-24
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these moisture-proof accessories all have the disadvantages of large dosage and low moisture-proof efficiency per unit weight. For example, the amount of acrylic resin and cellulose moisture-proof accessories is at least 10%.

Method used

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  • Moisture protection method of traditional Chinese medicine extract and solid preparation obtained by traditional Chinese medicine
  • Moisture protection method of traditional Chinese medicine extract and solid preparation obtained by traditional Chinese medicine
  • Moisture protection method of traditional Chinese medicine extract and solid preparation obtained by traditional Chinese medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 The effect of leucine on yield and fluidity

[0050] Shuanghuanglian extract was prepared according to the preparation method described in "Shuanghuanglian Injection" on page Z11-38 of "Ministry Standards" WS3-B-2104-96, and accurately weighed 2g of this extract in four parts, each placed in 70ml volumetric flask, respectively, ultrasonically dissolved in water to obtain the extract solution of Shuanghuanglian. Weigh 0.06g, 0.1g, 0.2g, 0.4g of leucine, and dissolve them in about 10ml of water, respectively, to prepare leucine aqueous solutions of different concentrations. The aqueous solutions of leucine of various concentrations were added to the four above-mentioned aqueous solutions of Shuanghuanglian extracts, sonicated to make them mixed, and then the volume was fixed to 100ml for use. The aqueous solution containing Shuanghuanglian extract and different concentrations of leucine was spray-dried under the following conditions: an inlet temperature of 100°C,...

Embodiment 2

[0055] Example 2 Effect of Leucine on Hygroscopicity and Particle State after Hygroscopicity

[0056] A Hydrosorb1000 water adsorption tester was used to measure the moisture absorption and desorption percentage change curve of each sample in Example 1. Precisely weigh about 100mg of each sample and place it in the glass tube of the water adsorption tester. At a temperature of 25.0±0.5℃ in the water bath, determine the moisture absorption and desorption percentage change curve of each sample under the change of relative humidity RH10%~90%. figure 2 . Draw the tangent line of the curve from the two ends of each adsorption curve. The abscissa of the intersection of the two tangent lines is the critical relative humidity CRH. The critical relative humidity of each sample particle is 65% to 70%. The addition of auxiliary materials can increase the CRH of the particles, and As the proportion of addition increases. Analyzing the desorption curve of each sample, it can be seen that th...

Embodiment 3

[0061] Example 3 Aerodynamic properties test of spray-dried particles of Shuanghuanglian (the effect of leucine in promoting particle dispersion and inhalation)

[0062] In Comparative Example 1, the difference between the dispersibility and inhalation of the dry powder inhalant prepared by spray-drying blank particles of Shuanghuanglian and adding 10% leucine group particles. Take the Shuanghuanglian spray-dried blank group particles and the 10% leucine group particles in Example 1, respectively Dry powder inhalation lactose is mixed in a ratio of 1:3 according to the principle of equal volume addition, and loaded in No. 3 HPMC capsule to obtain a dry powder inhalant.

[0063] The inhalation evaluation of dry powder inhalants was carried out using the Next Generation Pharmaceutical Impactor (NGI), referring to the 2007 edition of the British Pharmacopoeia Appendix VII F. Apparatus E. Specifically, after assembling the NGI according to the instructions, adjust the pumping speed to...

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Abstract

The invention relates to a moisture protection method of traditional Chinese medicine extract. The method comprises the following steps: firstly, dissolving or suspending traditional Chinese medicine extract in a dispersing agent so as to obtain traditional Chinese medicine extract solution or suspension with the concentration being 5 to 300mg / ml, secondly, weighing moisture-proof auxiliary material, the weight of which is 3 to 20 percent of that of the traditional Chinese medicine extract, dissolving the moisture-proof auxiliary material in the dispersing agent, so as to obtain moisture-proof auxiliary material solution, and thirdly, uniformly mixing the traditional Chinese medicine extract solution or suspension in the first step with the moisture-proof auxiliary material solution in the second step, drying and removing the dispersing agent in the second step, so as to obtain traditional Chinese medicine extract bulk drug, wherein the dispersing agent in the first and second steps adopts water or solution of ethanol and water mixed according to arbitrary proportion; and the moisture-proof auxiliary material adopts leucine. The method has the advantages that the use level of leucine is low, the moisture protection effect is obvious, the productivity of prepared particles can be improved, simultaneously the flowability and the dispersibility of the prepared particles are improved, and the method is simple and the quality of preparation is improved.

Description

Technical field [0001] The invention relates to a moisture-proof method, in particular to a moisture-proof method for Chinese medicine extracts and a Chinese medicine solid preparation obtained by the method. Background technique [0002] 1. The influence of hygroscopicity on traditional Chinese medicine preparations [0003] The reason why traditional Chinese medicine extract preparations and whole powder preparations are easy to absorb moisture is that they contain a large amount of hygroscopic components such as protein, polysaccharides, starch, mucus, tannin and other components. Such components contain a large number of hydroxyl, amino and other extreme components. The sexual group is easy to combine with the polar hydroxyl group in the water molecule, and it is very easy to absorb moisture, and this kind of component has a strong ability to bind water, which further intensifies the hygroscopicity of the powder of Chinese medicine extract. The moisture absorption process of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/18
Inventor 廖永红杨晶晶权丽辉刘春雨常跃兴
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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