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Application of panaxadiol saponins fraction in preparing medicine for preventing dermatitis and scar

A technology of ginseng diol saponin and ginsenoside, which is applied in the field of medicine, can solve difficult problems such as medicinal value, and achieve the effect of stable drug effect and clear active ingredients

Active Publication Date: 2012-10-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This makes it difficult to realize the medicinal value of ginseng or American ginseng or their total saponins products to effectively treat excitatory or inhibitory diseases and symptoms

Method used

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  • Application of panaxadiol saponins fraction in preparing medicine for preventing dermatitis and scar
  • Application of panaxadiol saponins fraction in preparing medicine for preventing dermatitis and scar
  • Application of panaxadiol saponins fraction in preparing medicine for preventing dermatitis and scar

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1 Preparation of Panaxadiol Saponin Fraction-A (PDSF-A) from Radix Ginseng

[0051] 1. Isolation and Purification of Panaxadiol Saponin Fraction-A (PDSF-A) :

[0052] Ginseng rhizome medicinal material (8000 grams, sample-A, five kinds of ginseng diol saponins Rb contained therein 1 , Rc, Rb 2 , Rb 3 and Rd content and their total content are shown in Table 5) after pulverizing into a coarse powder, use 50% ethanol aqueous solution to percolate and extract until the extract is colorless, combine the percolate to recover ethanol under reduced pressure and freeze-dry to obtain the extract (678.6 gram). The medicinal extract was dissolved in 3000 milliliters of 45% ethanol aqueous solution, and the sample liquid was separated by macroporous adsorption resin (Diaion HP-20, 6000 grams) column chromatography, and first eluted with 45% ethanol aqueous solution until the eluent had no obvious saponin reaction, and then eluted with 70% ethanol aqueous solution u...

Embodiment 2

[0075] Example 2 Preparation of Panaxadiol Saponin Component-B (PDSF-B) from American Ginseng Rhizome

[0076] With American ginseng rhizome medicinal material (7000 grams, sample-B, five kinds of ginseng diol saponins Rb contained therein 1 , Rc, Rb 2 , Rb 3 and the content of Rd and their total content are shown in Table 5, and its HPLC collection is shown in Figure 1-3 ), adopt the same method of embodiment one to prepare the ginseng diol saponin component - B (PDSF-B, 101.3 g). HPLC analysis shows: PDSF-B also contains ginsenoside Rb 1 , Rc, Rb 2 , Rb 3 and Rd five kinds of ginsenosides, the total content of these five kinds of saponins is 91.60%, of which ginsenoside Rb 1 The highest content, followed by Rb 3 , Rd, Rb 2 and Rc; and Rb in Panaxadiol Saponin Fraction-B 1 / Rc / Rb 2 / Rb 3 / Rd content ratio and Rb in American ginseng rhizome (sample-B) 1 / Rc / Rb 2 / Rb 3 The content ratio of / Rd is basically the same (Table 5).

Embodiment 3

[0077] Example 3 Preparation of Panaxadiol Saponin Component-C ( PDSF -C)

[0078] Purchased commodity ginseng rhizome total saponins (sample-C 1 , its total saponin content ≥ 80%) and American ginseng stem and leaf total saponin (sample-C 2 , its total saponin content ≥ 80%) show through HPLC analysis, five kinds of ginseng diol saponins contained in these two kinds of total ginsenoside products have their own characteristics respectively, namely: Sample-C 1 Both contain ginsenoside Rb 1 , Rc, Rb 2 , Rb 3 and Rd, but Rb 3 The content is very low (see attached diagram 2-1 and Table 5); Sample-C 2 Contains mainly Rb 3 and Rd, and Rb 1 , Rc and Rb 2 The content is very low (see attached Figure 2-2 and Table 5). This implementation comprehensively utilizes these two samples (sample-C 1 and sample-C 2 ) as this raw material to prepare the ginsengdiol saponin active component of the present invention, especially to obtain the total content of five kinds of ginseng...

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Abstract

The invention provides application of a panaxadiol saponins fraction in preparing a medicine for preventing dermatitis and scar and a health-care cosmetic. The panaxadiol saponins fraction comprises the following main constituents: ginsenoside Rb1, ginsenoside Rb2, ginsenoside Rb3, ginsenoside Rc and ginsenoside Rd. The medicine or the cosmetic is prepared from active constituents in the single panaxadiol saponins fraction or / and other medicines together and a pharmaceutically acceptable or cosmetic acceptable carrier. The medicine or the cosmetic is prepared by utilizing raw materials: ginseng rhizome medicinal materials, American ginseng rhizome medicinal materials, ginseng stem leaf medicinal materials, American ginseng leaf medicinal materials and total extractives or total saponins of the ginseng rhizome medicinal materials, the American ginseng rhizome medicinal materials, the ginseng stem leaf medicinal materials and American ginseng leaf medicinal materials through a chromatographic separation and purification method combining macroporous resin column chromatography and octadecylsilane chemically bonded silica column chromatography. The scar can be prevented from forming while the tissue regeneration and repair are promoted by the medicine or the cosmetic. Compared with glucocorticoids, cellular immunity is integrally regulated, the drug action is stable after the medicine is suspended, and the drug action advantage is obvious. The medicine or the health-care cosmetic is highly safe. The structural formula of panaxadiol saponins is shown in the specification.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the preparation of a panaxadiol saponins active component (hereinafter referred to as panaxadiol saponins fraction, Panaxadiol Saponins Fraction, PDSF) and a kind of medicine containing panaxadiol saponins fraction (PDSF) in the prevention and treatment of dermatitis and Application in scars. More specifically, a method of comprehensively utilizing ginseng, American ginseng medicinal materials, their stems and leaves, their extracts or total saponins to prepare ginseng diol saponin components; Preparations or cosmetic health products are used in the treatment and prevention of dermatitis (including allergic, contact and cosmetic dermatitis and drug eruption) and the prevention of scar formation. Background technique [0002] Dermatitis and eczema are often used synonymously to refer to a type of skin inflammation that represents an allergic reaction of the skin to substances such as chemic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K36/258A61P17/00A61P17/02A61P37/08A61K8/63A61K8/97A61Q19/00
Inventor 连晓媛郭欣张治针乔慧
Owner ZHEJIANG UNIV
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