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Preparation method of polysaccharide-nanometer bacterial cellulose composite wound dressing

A nano-bacteria, wound dressing technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of water permeability, ventilation or drainage, poor moisture absorption effect, etc., achieve excellent biocompatibility, promote healing, and reduce the effect of infection

Active Publication Date: 2012-10-17
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the antibacterial properties of nano bacterial cellulose, the problem of hemostasis, and the problem of rapid wound healing, and at the same time overcome the problems of water permeability, air permeability or drainage, and poor moisture absorption effect of existing polysaccharides

Method used

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  • Preparation method of polysaccharide-nanometer bacterial cellulose composite wound dressing
  • Preparation method of polysaccharide-nanometer bacterial cellulose composite wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The commercially available nano-bacteria cellulose film made by Acetobacter xylinum is cut into a nano-bacteria cellulose film with a diameter of 15mm, and the steps are as follows:

[0034] Step 1, pretreatment and purification of nano bacterial cellulose membrane

[0035] Take the nano-bacterial cellulose and wash it with clean water several times to remove the culture medium and impurities on the surface of the membrane. Then soak the membrane in 0.1mol / L NaOH solution, boil at 80°C for 75min, and wash out the bacteria and residual culture medium in the nano-bacterial cellulose membrane. Then soak the nano-bacterial cellulose membrane in 0.05mol / L NaOH solution, boil it at 80°C for 60 minutes, and then rinse it with distilled water several times; then sterilize it with ultraviolet rays to meet the sterilization requirements of the process (the subsequent process requires aseptic operation); Soak the nano-bacterial cellulose film after the above disinfection with dis...

Embodiment 2

[0045] The commercially available nano-bacterial cellulose film prepared by Acetobacter xylinum was cut into a 10×10 cm nano-bacterial cellulose sample.

[0046] Step 1, pretreatment and purification of nano bacterial cellulose membrane

[0047] Take the nano-bacterial cellulose and wash it with clean water several times to remove the culture medium and impurities on the surface of the membrane. Then soak the membrane in 0.1mol / L NaOH solution, boil at 85°C for 75min, and wash out the bacteria and residual culture medium in the nano-bacterial cellulose membrane. Then soak the nano-bacterial cellulose membrane in 0.05mol / L NaOH solution, boil it at 85°C for 60 minutes, and then rinse it with distilled water several times; then sterilize it with ultraviolet rays to meet the sterilization requirements of the process (the subsequent process requires aseptic operation); Soak the nano-bacterial cellulose film after the above-mentioned disinfection with distilled water for 4 times, ...

Embodiment 3

[0057] The commercially available nano-bacterial cellulose film prepared by Acetobacter xylinum was cut into a 10×10 cm nano-bacterial cellulose sample.

[0058] Step 1, pretreatment and purification of nano bacterial cellulose membrane

[0059] Take the nano-bacterial cellulose and wash it with clean water several times to remove the culture medium and impurities on the surface of the membrane. Then soak the membrane in 0.1mol / L NaOH solution, boil it at 90°C for 75 minutes, and wash out the bacterial cells and residual medium in the nano-bacterial cellulose membrane. Then soak the nano-bacterial cellulose membrane in 0.05mol / L NaOH solution, boil it at 90°C for 60 minutes, and then rinse it with distilled water several times; then sterilize it with ultraviolet rays to meet the sterilization requirements of the process (the subsequent process requires aseptic operation); Soak the nano-bacterial cellulose film after the above-mentioned disinfection with distilled water for 4 ...

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Abstract

Belonging to the field of biomedical materials, the invention relates to a preparation method of a polysaccharide-nanometer bacterial cellulose composite wound dressing. The method specifically consists of the steps of: taking a nanometer bacterial cellulose membrane for pretreatment and purification treatment so as to obtain purified nanometer bacterial cellulose, then preparing a polysaccharide solution with a concentration of 0.1-10%, removing part of water from the nanometer bacterial cellulose membrane, then compounding it with a polysaccharide solution by means of soaking, tape casting or spraying so as to obtain a polysaccharide-nanometer bacterial cellulose composite membrane, then conducting extrusion dewatering and ionizing radiation disinfection, thus obtaining the polysaccharide-nanometer bacterial cellulose composite wound dressing. The dressing of the invention has the advantages of good biocompatibility, cellular affinity and antibacterial property as well as mechanical property, excellent permeability, breathability or drainage, and moisture absorption effects, and has the efficacy of sterilization, inflammation diminishing, hemostasis, pain relieving, infection reduction and the like. At the same time, the dressing can promote wound surface drying, incrustation and healing, and can be used to treat burns or scalds, open wounds, ulcers, chronic wounds and stubborn infected wound surfaces, etc.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method and application of several biomacromolecule polysaccharides and nano-bacteria cellulose composite wound dressings. Background technique [0002] Traditional dressings such as various gauzes and cotton pads are the main dressings currently used clinically. Traditional dressings are low in cost, have a wide range of sources of raw materials, are soft in texture, have strong absorption capacity and can prevent the accumulation of wound exudate, and have a certain effect on the wound surface. Protective effect is still widely used in various types of trauma. However, with the further understanding and requirements for wound healing, traditional dressings have increasingly shown their limitations, such as no promoting effect on wound healing, no moisturizing effect, granulation tissue is easy to grow into the gauze mesh to cause adhesion and scab, a...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42
Inventor 郑裕东崔秋艳吴健高爽栾家斌刘国权
Owner UNIV OF SCI & TECH BEIJING
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