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D-glutamyl-D-tryptophan sodium colon targeting drug delivery agent and preparation method thereof

A technology of colon positioning and sodium tryptophan, which can be used in pharmaceutical formulations, drug delivery, sugar-coated pills, etc., and can solve problems such as inaccurate positioning

Inactive Publication Date: 2012-10-17
HYBIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, the above-mentioned oral colon-targeted drug release system is affected by various factors in the body, resulting in inaccurate positioning

Method used

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  • D-glutamyl-D-tryptophan sodium colon targeting drug delivery agent and preparation method thereof
  • D-glutamyl-D-tryptophan sodium colon targeting drug delivery agent and preparation method thereof
  • D-glutamyl-D-tryptophan sodium colon targeting drug delivery agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1D

[0097] Preparation of Example 1 D-Glutamyl-D-Tryptophan Sodium Colon-localized Release Tablets

[0098] Tablet prescription:

[0099]

[0100] pH Control Layer Prescription:

[0101]

[0102]

[0103] Flora Trigger Layer Prescription:

[0104]

[0105] Preparation Process:

[0106] The mass ratio of the tablet core, pH control layer and flora trigger layer is 0.5:0.25:0.25.

[0107] Tablet core: Weigh the prescribed amount of starch and low-substituted hydroxypropyl cellulose, mix them evenly, and pass through an 80-mesh sieve for later use. Dissolve polyvinylpyrrolidone in absolute ethanol to prepare a 30% solution. Use 30% polyvinylpyrrolidone solution as a binder, add an appropriate amount of starch and low-substituted hydroxypropyl cellulose to make soft materials, pass through a 24-mesh sieve, granulate, dry in an oven at 60°C, and pass through a 40-mesh sieve. grain. The prescription amount of D-glutamyl-D-tryptophan sodium is mixed with the whole grain...

Embodiment 2D

[0111] Preparation of embodiment 2 D-glutamyl-D-tryptophan sodium colon localized release pill

[0112] Ball core prescription:

[0113]

[0114] pH Control Layer Prescription:

[0115]

[0116] Flora Trigger Layer Prescription:

[0117]

[0118] Preparation Process:

[0119] The mass ratio of tablet core, pH control layer and flora trigger layer is 4:2:0.5.

[0120] Tablet core: Weigh the prescribed amount of microcrystalline cellulose and cross-linked polyvinylpyrrolidone, mix them evenly, and pass through an 80-mesh sieve to prepare the first mixture for later use. Polyethylene glycol was dissolved in absolute ethanol to prepare a 30% solution. Use 20% polyethylene glycol solution as a binder, add it to the first mixture, make a soft material, pass through a 24-mesh sieve, granulate, dry in an oven at 60°C, and pass through a 40-mesh sieve for granulation. The prescription amount of D-glutamyl-D-tryptophan sodium is mixed with the whole grains by equal addition ...

Embodiment 3D

[0124] Preparation of Example 3 D-Glutamyl-D-Tryptophan Sodium Colon-localized Drug Release Capsules

[0125] Ball core prescription:

[0126]

[0127] pH Control Layer Prescription:

[0128]

[0129] Flora Trigger Layer Prescription:

[0130]

[0131]

[0132] Preparation Process:

[0133] The mass ratio of tablet core, pH control layer and flora trigger layer is 2:1:1.5.

[0134] Tablet core: weigh the prescribed amount of mannitol and microcrystalline cellulose, mix them evenly, and pass through an 80-mesh sieve to prepare the first mixture for later use. Use absolute ethanol to dissolve the starch slurry to prepare a 40% starch slurry solution. Use 40% starch slurry solution as a binder, add it to the first mixture, make a soft material, pass through a 24-mesh sieve, granulate, dry in an oven at 60°C, and pass through a 40-mesh sieve for granulation. Add the prescribed amount of D-glutamyl-D-tryptophan sodium to the whole grains by equal addition method, t...

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Abstract

The present invention relates to the field of targeting drug delivery agents of polypeptide drugs, and particularly to a D-glutamyl-D-tryptophan sodium colon targeting delivery agent and a preparation method thereof. The colon targeting delivery agent comprises a tablet core, a pH value control layer, and a flora trigger layer. With the colon targeting drug delivery agent, the purpose of colon targeting drug delivery can be achieved, bioavailability of the D-glutamyl-D-tryptophan sodium is improved, and good mixing hardness and low toxicity of the agent of the present invention are provided compared with injection administration and nasal administration.

Description

technical field [0001] The invention relates to the field of polypeptide drug localized release preparations, in particular to a D-glutamyl-D-tryptophan sodium colon localized drug release preparation and a preparation method thereof. Background technique [0002] Psoriasis, also known as psoriasis, is a common chronic, stubborn, and relapse-prone skin disease, characterized by the repeated appearance of multiple layers of silvery white dry scales on erythema, characterized by the appearance of papules of various sizes, erythema, and surface coverage With silvery white scales, the boundary is clear, and there will be bleeding spots after the silvery white scales are peeled off. Occurs in scalp, extensor limbs and back. Though psoriasis does not directly affect life, the course of disease is long and difficult to cure, and has direct impact on health and physical and mental health. Psoriasis is not contagious, but the etiology of psoriasis is more complicated, and the cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/28A61K38/05A61P17/06
Inventor 卢晓慧黄怀马亚平袁建成
Owner HYBIO PHARMA
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