Compound spirolactone nanoemulsion drug

Abstract

The invention discloses a compound spirolactone nanoemulsion drug. The nano drug is prepared from the following materials in mass percentage: 1%-15% of spirolactone, 15%-35% of surfactant, 5%-20% of cosurfactant, 5%-20% of oil, 0.5%-10% of hawthorn extract, 0.5%-10% of asarum extract and the balance of distilled water, wherein the sum of the mass percentages of the ingredients is 100%. According to the invention, after the spirolactone is prepared into nanoemulsion dosage form, the ability of penetrating blood brain barrier is obviously increased, the bioavailability of active compound is obviously improved, the half-life period of the drug is prolonged, and the administration times are reduced. The dissolving and penetrating abilities of the drug of the spirolactone are improved by the nanoemulsion, and the stability of the spirolactone is increased. The spirolactone nanoemulsion drug has obvious synergistic effect after being combined with aqueous extract of the hawthorn and asarum, and the curative effect of the drug is brought into full play.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of an antihypertensive drug spironolactone, in particular to a compound spironolactone nanoemulsion drug. Background technique [0002] Spironolactone (spironolactone, Antisterone, Aldactine, Aldonar, Verospiron, spirolang) chemical name 17β-hydroxy-3-oxo-7α-(acetylthio)-17α-pregn-4-ene-21-carboxylic acid gamma-lactone , the molecular formula is C 24 h 32 o 4 S, molecular weight 416.57, CAS No. 52-01-7. [0003] Existing antihypertensive drugs such as spironolactone tablets are available on the market now, although they can be absorbed from the gastrointestinal tract after oral administration, the absorption rate is slow and incomplete. In addition, the dissolution rate of the drug in the tablet is slow and the bioavailability is poor. Spironolactone itself acts slowly, so that the drug effect of spironolactone cannot be utilized quickly. [0004] Contents of the i...

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Problems solved by technology

[0003] Existing antihypertensive drugs such as spironolactone tablets are available on the market now, although they can be absorbed from the gastrointestinal tract after oral administration, the absorption rate is slow and incomplete. In addition, the dissolution rate of the drug in the tablet is slow and the bioavailability is poor. Spironolactone itself acts slowly, so that the drug effect of spironolactone cannot be utilized quickly