Method for preparing mouse gastric intubation model

Abstract

The invention discloses a method for preparing a mouse gastric intubation model. The method is characterized in that the head end of a gastric intubation is enabled to take the shape of an umbrella through the steps of manufacturing of the gastric intubation, neck operation, abdomen operation, installation of the gastric intubation, fixing of the gastric intubation, and the like, and a silica-gel sphere is arranged behind the umbrella-shaped head end, so that the gastric intubation cannot be pulled out from the gastric wall or retract into the stomach; the gastric intubation is firmly fixed with the gastric wall and is fixed on the neck through a twin twisted thin wire and an adhesive tape; when a mouse with poor capacity for action is in a waking state, the mouse gastric intubation model can still be used normally, so that the mouse can be observed continuously and dynamically in the waking state, toxicology, pharmacology and nutriology of drug or nutrient given by the stomach can be studied, and the obtained data is more accurate; and meanwhile, under the condition that the gastric intubation is not divorced from the gastric wall, the mouse gastric intubation model can be used for a long time, so that the trouble that a mouse gastric intubation model needs to be manufactured again when in use can be eliminated.

Description

technical field [0001] The invention relates to an animal gastric intubation model, in particular to a preparation method for a mouse gastric intubation model. Background technique [0002] The animal gastric intubation model is a more accurate model for the administration of drugs or nutrients to the stomach to study the decomposition, metabolism, and absorption of drugs or nutrients. This animal model plays a very important role in animal experiments such as toxicology, pharmacology, and nutrition. status. At present, animal gastric intubation models generally use larger animals such as dogs, rabbits, and rats as model animals, and the production of gastric intubation is mostly a straight polyethylene catheter, and the end of the tube is sutured to the stomach wall. A stainless steel gasket is inlaid at the end to prevent the gastric cannula from protruding from the gastric body. However, due to the vigor of larger animals, it is easy to separate the gastric cannula from...

AI Technical Summary

Problems solved by technology

At present, animal gastric intubation models generally use larger animals such as dogs, rabbits, and rats as model animals, and most of the gastric intubation is made of a straight polyethylene catheter, and the end of the tube is sutured to the stomach wall. A stainless steel gasket is inlaid at the end to prevent the gastric cannula from protruding from the gastric body. However, due to the vigor of larger animals, it is easy to separate the gastric cannula from the gastric wall, resulting in the failure of the gastric cannula model. Therefore, gastric administration of drugs or Toxicology, pharmacology and nutrition research of nutrients, so the current animal gastric intubation model is generally a model in the animal's unconscious state, and each anesthesia gastric intubation model is important for the study of toxicology, pharmacology and nutrition Shorter time frame and less accurate data for toxicology, pharmacology, and nutrition

In the animal model produced at the same time, the proportion of foreign substances in the stomach of the animal is relatively large, which also affects the eating and digestion functions of the animal, so more realistic experimental data cannot be obtained

Images