Silicone hydrogel with high water content

A polysiloxane and hydrogel technology, used in medical science, instruments, glasses/goggles, etc., can solve the problems of inability to obtain wearing comfort, water loss, and short-term comfort effects, and improve surface wettability. Poor, high moisture content, the effect of reducing the water loss rate

Inactive Publication Date: 2012-09-19
FAR EASTERN NEW CENTURY COPRRATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these physical methods can successfully improve the wetting effect of the contact lens surface, they cannot effectively increase the moisture content of the contact lens itself, resulting in only a short-term comfort effect when wearing the contact lens improved by the above methods , and cannot obtain long-term wearing comfort
[0007] As far as comfort is concerned, long-term wear of contact lenses often results in dry, uncomfortable eyes due to the rapid loss of water from the lenses, insufficient tear supply from the lacrimal glands, or prolonged contact with the outside world. Moisture loss due to exposure to air
The above conditions may cause contact lens wearers to experience dry eyes, or may even cause poor vision problems

Method used

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  • Silicone hydrogel with high water content
  • Silicone hydrogel with high water content
  • Silicone hydrogel with high water content

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0041] synthetic chemicals

[0042] 1. 2-Hydroxyethyl methacrylate (HEMA for short): Purchased from Sigma.

[0043] 2. N-vinylpyrrolidone (NVP for short): Purchased from Sigma Corporation.

[0044] 3. Methacrylic acid (MA): Purchased from Sigma Corporation.

[0045] 4. (Trimethylsilyloxy)-3-methacryloxypropylsilane (TRIS): Purchased from Sigma Corporation.

[0046] 5. CoatOsil: Purchased from Momentive.

[0047] 6. Ethylene glycol dimethacrylate (EGDMA): Purchased from Sigma Corporation.

[0048] 7. D1173 photoinitiator: purchased from Ciba Chemicals.

[0049] Preparation of polysiloxane hydrogel materials

example 1

[0051] According to the composition and content shown in formula 1 in Table 1, the components were uniformly mixed, and cross-linked and polymerized by ultraviolet light for 60 minutes, and the completed polymer was soaked in 50% alcohol for 20 minutes, and then extracted with 70% alcohol for 60 minutes. minutes to remove unreacted monomer. Soak the prepared polysiloxane hydrogel film in sodium bicarbonate (NaHCO 3 ) solution for 60 minutes, and then soaked in normal saline for 60 minutes for replacement, and finally the obtained film was soaked in normal saline for 120 minutes to reach the balance of water content.

example 2

[0053] The same feed ratio and reaction conditions as in Example 1, but the prepared polysiloxane hydrogel film was soaked in a sodium hydroxide (NaOH) solution with a pH of 9 for 60 minutes, and then soaked in physiological saline for 60 minutes. Replacement is carried out, and finally the obtained film is soaked in physiological saline for 120 minutes to reach the balance of water content.

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Abstract

The invention provides a silicone hydrogel. The silicone hydrogel comprises a reaction product of a monomer mixture for forming the silicone hydrogel, and water, wherein the water is not less than 50 percent of the total weight of the integral silicone hydrogel; the monomer mixture comprises at least one silicon-containing monomer and at least one ionic monomer; and the ionic monomer is not less than 0.7 percent of the total weight of the dry weight of the integral silicone hydrogel. The invention also provides an ophthalmic object prepared from the silicone hydrogel.

Description

technical field [0001] The present invention relates to a polysiloxane hydrogel with high water content. The present invention also relates to improved ophthalmic articles, particularly contact lenses or intraocular lenses (IOLs), made thereby. Background technique [0002] Contact lenses have been developed for nearly a hundred years and are one of the important medical devices commonly used by the general eyewear family. In the 1950s, Czech scientists invented soft contact lenses using poly(hydroxyethyl methacrylate; HEMA) materials to make hydrogels, which are still used today. With the advancement of technology, the evolution of contact lens materials is also developing towards high oxygen permeability and high comfort. [0003] The development of contact lenses made of silicone hydrogel has a history of many years. In the past, the development goals of these products were mainly to improve the oxygen permeability and water content of silicone hydrogel. The oxygen per...

Claims

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Application Information

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IPC IPC(8): C08F290/06C08F283/12C08F220/28C08F226/10C08F220/06C08F230/08C08F222/14C08J3/075A61L27/16G02C7/04
Inventor 张根源李致达黄锦平张怡萱
Owner FAR EASTERN NEW CENTURY COPRRATION
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