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Medicinal composition for preventing and treating osteoporosis

A technology of osteoporosis and composition, applied in the field of medicine, can solve the problem of not inhibiting bone resorption and the like

Inactive Publication Date: 2012-09-19
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vitamin D promotes the deposition of calcium at the site of new bone formation, deposits hydroxyphosphate in the bone, promotes bone calcification, osteoblast function and maturation of bone-like tissue. It is a commonly used clinical bone activator, but it cannot inhibit bone resorption.

Method used

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  • Medicinal composition for preventing and treating osteoporosis
  • Medicinal composition for preventing and treating osteoporosis
  • Medicinal composition for preventing and treating osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Alendronate, Alfacalcidol Softgels

[0016] prescription:

[0017]

[0018] Glue: dry gelatin: glycerin: water: titanium dioxide = 1:0.5:0.8:0.05

[0019] Preparation:

[0020] Content preparation: Weigh the prescription amount of alendronate, alfacalcidol, PEG400, glycerin, mix and dissolve and stir evenly, set aside;

[0021] Preparation of glue solution: first add water and glycerin (reserved 0.08%) into the glue tank in proportion to heat and stir, add gelatin when it is heated to 65-75°C, and continue stirring until the gelatin melts in hot water and becomes with glycerin and water After uniform glue solution, vacuumize while stirring until there are no air bubbles; weigh titanium dioxide, mix it with the reserved glycerin, add it to the colloid mill to grind it evenly, add it to the above glue solution, stir until the color is uniform, and the glue is prepared. liquid;

[0022] Pressing pills, shaping, drying: make the above glue into 0.5-1.0mm rubber, put ...

Embodiment 2

[0024] Clodronate, Alfacalcidol Soft Capsules

[0025] prescription:

[0026]

[0027]

[0028] Glue: dry gelatin: glycerin: water: titanium dioxide = 1:0.6:0.9:0.06

[0029] Preparation:

[0030] Contents preparation: Weigh the prescribed amount of clodronate, alfacalcidol, PEG400, glycerin, mix and dissolve, stir evenly, and set aside;

[0031] Preparation of glue solution: first add water and glycerin (reserved 0.08%) into the glue tank in proportion to heat and stir, add gelatin when it is heated to 65-75°C, and continue stirring until the gelatin melts in hot water and becomes with glycerin and water After uniform glue, vacuumize while stirring until there are no air bubbles; weigh silicon dioxide, mix with reserved glycerin, add colloid mill to grind evenly, add to the above glue, stir until the color is uniform, and the preparation is obtained good glue;

[0032] Pressing pills, shaping, drying: make the above glue into 0.5-1.0mm rubber, put the content into t...

Embodiment 3

[0034] Sodium etidronate, paricalcitol soft capsules

[0035] prescription:

[0036]

[0037] Glue: dry gelatin: glycerin: sorbitol: water: titanium dioxide = 1:0.5:0.1:0.7:0.05

[0038] Preparation:

[0039] Contents preparation: Weigh the prescribed amount of etidronate sodium, paricalcitol, and soybean oil, mix and dissolve, stir evenly, and set aside;

[0040] Glue preparation: first add water, glycerin (reserved 0.08%), and sorbitol into the glue pot in proportion to heat and stir, add gelatin when heated to 65-75°C, and continue stirring until the gelatin is melted in hot water and mixed with sorbitol After the alcohol, glycerin, and water become a uniform glue, vacuumize while stirring until there are no bubbles; weigh titanium dioxide, mix it with the reserved glycerin, add it to the colloid mill to grind it evenly, add it to the above glue, and stir until the color is uniform , that is to prepare the glue;

[0041] Pressing pills, shaping, drying: make the abov...

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Abstract

The invention discloses a medicinal composition for preventing and treating osteoporosis, relates to a medicinal composition of bishosphonates and the derivatives of vitamin D and the like, wherein the medicinal composition can be produced into oral preparations or injection preparations by virtue of being mixed with pharmaceutically acceptable auxiliary materials; the oral preparations comprise soft capsules, capsules, common tablets, chewable tablets, dispersible tablets, orally disintegrating tablets, effervescent tablets, buccal tablets, sustained release tablets, sustained release capsules, oral solution, syrup, and the like; and the injection preparations comprise small-volume injections, large-volume injections, freeze-dried powder for injection, and the like. The medicinal composition can be used for preventing and treating various primary or secondary types of osteoporosis.

Description

technical field [0001] The invention relates to a medicinal composition for preventing and treating osteoporosis, which belongs to the technical field of medicine. Background technique [0002] Osteoporosis is a systemic bone disease characterized by low bone mass, destruction of bone microarchitecture, increased bone fragility, and susceptibility to fracture. In 2001, the National Institutes of Health (NIH) proposed that the disease is a disease of the skeletal system characterized by decreased bone strength and increased risk of fracture. Bone strength reflects two main aspects of bone, namely bone mineral density and bone quality. The disease can occur in different genders and at any age, but it is more common in postmenopausal women and older men. Symptoms are divided into two categories: primary and secondary. Primary disease is divided into postmenopausal disease (I type), senile disease (II type) and idiopathic (including juvenile type) 3 kinds again. Postmenopaus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/663A61P19/10A61K31/592
Inventor 不公告发明人
Owner FUKANGREN BIO PHARMA
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