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Photo-sensitizer composition, and using method and application thereof

A technology of composition and photosensitizer, applied in the field of pharmacy, can solve the problems of insufficient drug absorption, difficult to treat lesions, short residence time, etc., and achieve the effects of convenient storage, stable state, and pain relief

Active Publication Date: 2012-09-19
上海复旦张江生物医药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, although the above-mentioned usual emulsion or solution products have good clinical curative effects, it is difficult to treat lesions in certain mucosal parts of the body, such as lesions in the digestive cavity, and female reproductive system (such as urethra, cervix, and vagina) lesions
Because, if the emulsion or solution is applied to the above-mentioned mucosal parts, the drug stays on the surface of the lesion for a short time, and the mucous membrane will secrete mucus when stimulated, which will dilute or even wash away the drug applied on the lesion, resulting in insufficient drug absorption in the lesion. , making it difficult to treat

Method used

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  • Photo-sensitizer composition, and using method and application thereof
  • Photo-sensitizer composition, and using method and application thereof
  • Photo-sensitizer composition, and using method and application thereof

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preparation example Construction

[0056] The photosensitizer composition of the present invention can be conveniently prepared after knowing the raw materials used and their formulations. The preparation method includes: mixing the photosensitizer composition with water to form a swelling product, and the mass ratio of the active ingredient to water in the swelling product is 1:9-1:3. The swollen product can be directly administered to the mucous membrane site of the patient as an administration preparation.

[0057] The present invention also provides a kit, which contains a kit for diagnosing or treating mucosal diseases, including: the photosensitizer composition described in the present invention; Use the instruction manual of the kit, which can record the method and ratio of photosensitizer composition and water compatibility.

Embodiment 8

[0107] Embodiment 8, medicine box

[0108] A kit is prepared, comprising:

[0109] The first container: wherein 4 parts by weight of 5-ALA are housed as an active ingredient;

[0110] The second container: the HPMC K100 of 1 weight part is housed therein; 0.336 weight part povidone (PVP) K30; 0.0128 weight part ethylparaben; 0.064 weight part polyethylene glycol; 0.002 weight part edetate di sodium.

[0111] When in use, first dissolve the content in the second container in water, then add the active ingredient in the first container, and apply it on the affected part after it dissolves.

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Abstract

The invention discloses a photo-sensitizer composition, and a using method and application thereof. The photo-sensitizer composition contains an active ingredient consisting of 5-aminolevulinic acid (5-ALA) or derivative thereof and hydroxypropyl methyl cellulose (HPMC), wherein, the mass ratio of the active ingredient to HPMC is 2:1-5:1. The composition is simple in formula, and a gelatinous swelling body can be quickly formed by mixing the composition and water in a certain ratio. Because the 5-ALA does not react with HPMC, incompatibility is not produced; and two main components can be stored in the same container, so that the production, packing and storage costs are reduced. The invention also discloses application of the composition in preparation of medicaments for diagnosing or treating mucosal part diseases.

Description

technical field [0001] The present invention belongs to the field of pharmacy; more specifically, the present invention relates to a composition containing 5-aminolevulinic acid or its derivatives and its application method, and also relates to the preparation of the composition for diagnosing or treating mucosal diseases. Drug use. Background technique [0002] Photodynamic therapy (PDT) is a relatively new technique that has been used to treat various diseases. The currently marketed active ingredients for photodynamic therapy and diagnosis are mainly 5-aminolevulinic acid (5-ALA) or its esters. [0003] It has been reported in the literature that 5-ALA or its derivatives can be used to treat various malignant or non-malignant skin, conjunctiva, respiratory tract and vaginal mucosa, endometrium, cervical cancer, etc. Bladder epithelial lesions and neoplastic diseases. For example, the methyl ester of 5-ALA developed by Photocure ASA (Oslo, Norway) and the hexyl ester ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/195A61K41/00A61K47/38A61K49/00
Inventor 蒋剑平苏勇张鹰峰陈毓婷张思佳
Owner 上海复旦张江生物医药股份有限公司
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