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Heat-resistant freeze-drying protecting agent for vaccine and preparing method

A heat-resistant freeze-drying and protective agent technology, which is applied in freeze-dried transportation, antiviral agents, pharmaceutical formulations, etc., can solve the problems of lagging development of protective agents, long-term storage of finished products, and limited transportation, achieving high aging resistance, The effect of solving technical bottlenecks and low virus loss rate

Inactive Publication Date: 2012-08-22
青岛爱博生物科技有限公司
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AI Technical Summary

Problems solved by technology

In addition, the development of domestic traditional veterinary biological product protective agents is relatively lagging behind, which limits the long-term storage and transportation of finished products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Preparation of heat-resistant freeze-dried vaccine of swine fever vaccine

[0018] 1) Mix commercially available chemically pure sodium carboxymethyl cellulose at 4-8% with deionized water, heat at 98-100°C for 30 minutes, and cool to room temperature (20°C) as liquid A.

[0019] 2) Mix commercially available food-grade xylo-oligosaccharide at 4-8% with deionized water, stir and mix well, and use it as liquid B.

[0020] 3) Mix glutamine at 4-8%, sodium selenite at 0.8-1.6%, and deionized water, stir and mix well, and use it as liquid C.

[0021] 4) Use liquid A, liquid B, and liquid C at a ratio of 1:1:1 (V / V) as the vaccine freeze-drying protective agent.

[0022] 5) Mix the vaccine freeze-dried protective agent with the swine fever vaccine virus liquid at a ratio of 3:1 (V / V) to make a swine fever freeze-dried vaccine production liquid.

[0023] 6) Freeze-dry after aliquoting.

[0024] 7) Sealing and packaging. Freeze at -20°C to -40°C, or store at 2°C ...

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Abstract

The invention relates to a heat-resistant freeze-drying protecting agent for a vaccine and a preparing method and particularly relates to a heat-resistant freeze-drying protecting agent for a hog cholera vaccine, which is formed by mixing and proportioning the following substances according to weight percent: 1 to 2 percent of sodium carboxymethylcellulose, 4 to 6 percent of xylo-oligosaccharide,1 to 2 percent of glutamine, 0.2 to 0.8 percent of sodium selenite and the balance distilled water. The preparing method of the heat-resistant freeze-drying protecting agent for the hog cholera vaccine comprises the following steps of: (1) mixing the sodium carboxymethylcellulose and the distilled water as A liquid; (2) mixing the xylo-oligosaccharide and the distilled water as B liquid; (3) mixing the glutamine, the sodium selenite and the distilled water as C liquid; and (4) mixing the A liquid, the B liquid and the C liquid according to 1:1:1 (V / V) as the heat-resistant freeze-drying protecting agent. According to the heat-resistant freeze-drying protecting agent for the hog cholera live vaccine, which is designed by the invention, the activity of viruses can be kept in the freeze-drying process and the preserving process, and the reduction of the activity of a modified-live vaccine for hog cholera viruses is relieved.

Description

technical field [0001] The invention relates to a heat-resistant freeze-drying protective agent for vaccines, in particular to a heat-resistant freeze-drying protective agent for swine fever vaccine, and a preparation method thereof, belonging to the field of veterinary drug production. Background technique [0002] At present, in my country's veterinary biological products, live freeze-dried vaccines account for a considerable proportion. The commonly used protective agents in China are mainly milk, sucrose, gelatin, etc., with simple formulations and poor protective functions. If it is stored at 2°C to 8°C, the storage period is only 4 to 6 months, and it needs to be stored below -15°C. In addition, the development of traditional veterinary biological product protective agents in China is relatively lagging behind, which limits the long-term storage and transportation of finished products. Therefore, research on heat-resistant freeze-drying protective agents is very urgen...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K47/26A61K47/18A61K47/04A61K39/187A61K9/19A61P31/14
Inventor 单虎常维山韩先杰秦晓冰黄娟杨瑞梅张传美
Owner 青岛爱博生物科技有限公司
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