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Graphene oxide and sanguinarine compound and preparation method thereof

A graphene and sanguinarine technology, applied in the field of graphene oxide-sanguinarine complex and its preparation, can solve the problems of poor water solubility, restricted use, poor bioavailability and the like of sanguinarine, so as to improve solubility and stability sexual effect

Inactive Publication Date: 2012-08-15
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Abstract
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Problems solved by technology

However, due to the poor water solubility of sanguinarine, it is difficult to be absorbed by the body, resulting in poor bioavailability, which limits its clinical use

Method used

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  • Graphene oxide and sanguinarine compound and preparation method thereof
  • Graphene oxide and sanguinarine compound and preparation method thereof
  • Graphene oxide and sanguinarine compound and preparation method thereof

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preparation example Construction

[0042] 1.1.2 Preparation of graphite oxide

[0043] Mix 1 g of pre-oxidized graphite with 23 ml of concentrated sulfuric acid, and slowly add 3 g of potassium permanganate under the condition of stirring the ice-water mixture (control the temperature below 20 °C during the process). Then the temperature was raised to 35°C and kept stirring for 2 h. Add 46 ml of distilled water, continue stirring for 15 min, and finally add 140 ml of distilled water. Then, 2 ml of 30% hydrogen peroxide was added to the reaction solution, at this time, the color of the solution turned into an obvious bright green. The mixture was centrifuged with 250 ml of 10% hydrochloric acid to remove excess metal ions. The obtained precipitate was repeatedly centrifuged and washed with distilled water until the solution was neutral.

[0044] 1.1.3 Exfoliation and purification of graphite oxide

[0045]In order to peel off GO flakes, 40 ml of distilled water was added to a centrifuge tube filled with grap...

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Abstract

The invention discloses a graphene oxide and sanguinarine compound and a preparation method thereof. The compound includes a graphene oxide carrier and sanguinarine loaded on the surface of the carrier via a non-covalent pi-pi action, the radial size of the graphene oxide carrier is smaller than or equal to 200nm, the thickness of the graphene oxide carrier is smaller than or equal to 1nm, and a six-arm PEG (polyethylene glycol) is further preferably decorated on the surface of the graphene oxide carrier. The preparation method includes steps of treating the surface of graphene oxide; accordingly forming an active linker on the surface of the graphene oxide; connecting the surface of the graphene oxide with high-polymer materials with hydrophobic groups via the active linker to form the graphene oxide carrier; steeping the graphene oxide carrier into organic solvent with the sanguinarine until the graphene oxide carrier absorbs the sanguinarine in a saturation manner; and then obtaining an objective product by means of separation. The graphene oxide and sanguinarine compound has the advantages that solubility and stability of the sanguinarine can be greatly improved, the sanguinarine has targeting property, and the graphene oxide and sanguinarine compound is expectably widely applied as an anticancer preparation with a huge potential.

Description

technical field [0001] The invention specifically relates to a graphene oxide-sanguinarine complex and a preparation method thereof. Background technique [0002] Malignant tumor is currently one of the major diseases that seriously affect human health and threaten human life. Its diagnosis and treatment have always been the focus and difficulty of many biologists and medical workers. Currently, cancer treatment methods mainly include surgery, radiation therapy, chemotherapy, and biological therapy. These therapeutic methods all have obvious toxic and side effects to human body. Therefore, screening out anti-cancer drugs with good therapeutic effects and low side effects is a scientific problem of common concern to mankind. [0003] Extracting new drugs with antitumor activity from Chinese herbal medicines is one of the hot spots in anticancer medicine research. With the help of modern extraction technology, effective anti-cancer components are extracted from Chines...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/4741A61P35/00A61K47/04A61K47/34
Inventor 崇羽张智军
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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