System for determining functions of lower limb nerves and muscles of rat

Abstract

The invention relates to a system for determining functions of lower lib nerves and muscles of a rat. The system consists of a fixing device, a sensing device and a data processing device, the fixing device is connected with the sensing device via an electrical stimulation line and an output line, the sensing device is connected with the data processing device via a lead, the data processing device transmits nerve stimulation signals to the fixing device via the sensing device, the fixing device transmits received mechanical muscle force signals into the sensing device, the mechanical muscle force signals are converted and processed into electric signals via the sensing device, and the electric signals are transmitted into the data processing device, so that muscle force data are obtained. Compared with the prior art, the system provides a novel and reliable experimental platform, can digitally, quantitatively and dynamically monitor a single group of muscle force of a rat model, and accurately measures change of the muscle force of a research object at different time points.

Description

technical field [0001] The invention relates to the field of clinical experiment research equipment, in particular to a measurement system for rat lower limb nerve and muscle functions. Background technique [0002] Rats are the most common animal model for basic and clinical experiments. It is often necessary to evaluate changes in muscle strength when studying clinical diseases such as peripheral nerve diseases and myopathy, and evaluating the efficacy of drugs such as botulinum toxin. Based on the behavioral habits of rats such as drilling, grasping, and running, currently commonly used experimental devices include rollers, conveyor belts, and grip rods, etc., which indirectly reflect changes in muscle strength through changes in physiological behavior. In most cases, these methods are relatively simple to operate and have no harm to mice. However, in most cases, the results they obtain are only qualitative or semi-quantitative, and the experimental process is also easil...

AI Technical Summary

Problems solved by technology

In most cases, these methods are relatively simple to operate and have no harm to mice. However, in most cases, the results they obtain are only qualitative or semi-quantitative, and the experimental process is also easily affected by many factors such as animals, experimental operators, and the environment. As a result, the error of the experimental results is relatively large, and the reliability and repeatability are poor.

At the same time, what it records is only the apparent situation of the muscle strength of the rat as a whole or a certain part of multiple groups, and cannot reflect the specific changes in the muscle strength of a single group. The changes under the joint action of many factors such as growth, the previous experimental devices are obviously not able to satisfy

Therefore, there is currently a lack of such a system for direct, rapid and accurate assessment of target muscles in rats.

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