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Methods of diagnosing and treating autism

An autism, selected technology, applied in the direction of disease diagnosis, instrument, drug combination, etc., can solve the problem of lack of etiological basis of ASD

Active Publication Date: 2012-07-11
RGT UNIV OF CALIFORNIA
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Problems solved by technology

Although a strong genetic association has been demonstrated in several reports (reviewed in Ashwood et al., J Leukoc Biol. (2006) 80(1): 1-15), a clear etiological basis for ASD is lacking

Method used

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  • Methods of diagnosing and treating autism
  • Methods of diagnosing and treating autism
  • Methods of diagnosing and treating autism

Examples

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Embodiment 1

[0236] Example 1: Identification of additional fetal brain antigens

[0237] This example summarizes the identification of fetal brain antigens bound by maternal antibodies with apparent molecular weights of 37 kDa, 39 kDa and 73 kDa.

[0238] Materials and methods

[0239] research object

[0240]As previously described (Hertz-Picciotto, et al., Environ Health Perspect, (2006) 114(7): 1119-25) as an ongoing CHARGE (Childhood Autism Risks from Genetics and Environment) study at the Davis California University M.I.N.D. Institute Consenting mothers were recruited as part of the Center for Children's Environmental Health (CCEH) through the Center for Children's Environmental Health (CCEH). The CHARGE study population came from three types: children considered autistic or autism spectrum disorder (ASD), children selected from the typically developing (TD) general population, and children with non-autistic developmental abnormalities ( developmental disability, DD) childre...

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Abstract

The present invention provides diagnostic methods for determining the risk of developing an autism spectrum disorder (ASD) in a fetus or child by detecting in a biological sample from the mother antibodies that bind to one or more biomarkers selected from the group consisting of lactate dehydrogenase (LDH), guanine deaminase (GDA), collapsin response mediator protein 1 (CRMP1), stress-induced phosphoprotein 1 (STIP1), alpha subunit of the barbed-end actin binding protein Cap Z (CAPZA2), Y Box Binding Protein 1 (YBX1), eukaryotic translation and elongation factor 1A1 (EEF1A1), microtubule-associated protein Tau (MAPT), dihydropyrimidinase-like protein 2 (DPYSL2), dynamin 1-like protein (DNM1L), radixin (RDX), moesin (MSN), and ezrin (EZR). The invention further provides methods of preventing or reducing the risk of a fetus or child developing an ASD by administering to the mother an agent that blocks the binding of maternal antibodies to the one or more fetal biomarkers listed above or by removing from the mother antibodies that bind to the one or more fetal biomarkers.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 61 / 234,110, filed August 14, 2009, the entire contents of which are hereby incorporated by reference for all purposes. [0003] Statement of Interest in Inventions Made in Federally Sponsored Research and Development [0004] This invention was made with government support under Grant 1-P01-ES11269-01 awarded by NIEHS and Grant R829388 awarded by EPA. The government has certain rights in this invention. field of invention [0005] The present invention relates to the diagnosis and prevention or suppression of autism spectrum disorder in fetuses. Background of the invention [0006] Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders that manifest in childhood and are defined as deficits in communication and interactive social relationships and are often accompanied by stereotypical behavior (American Psychiatr...

Claims

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Application Information

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IPC IPC(8): G01N33/564G01N33/68
CPCG01N2800/28G01N2800/50G01N33/6896G01N33/564A61P25/00A61P25/18G01N33/6854G01N33/54313
Inventor 朱蒂·万德瓦特丹尼尔·布劳恩施魏格
Owner RGT UNIV OF CALIFORNIA
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