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Use of GSTP1

A technology for cardiomyopathy and ischemic heart disease, applied in the direction of medical preparations containing active ingredients, measurement/testing of microorganisms, resistance to vector-borne diseases, etc., can solve unknown and beneficial problems

Inactive Publication Date: 2012-07-11
MEDIZINISCHE UNIVET WIEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Additionally, it remains unknown whether proBNP is beneficial in maintaining the diagnosis as opposed to reduced ejection fraction (EF) CMP

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0075] 1. GSTP1 improves inflammation in cardiomyopathy (CMP) and ischemic heart disease (IHD)

[0076] Patient and Tissue Sampling

[0077] The study was approved by the Ethics Committee of the Medical University of Vienna. Cardiac tissue samples from 70 CMP patients (idiopathic dilated cardiomyopathy (DCM), n=35; ischemic cardiomyopathy (ICM), n=35) who were enrolled and given informed consent were used for the initial Array analysis. Subsequently, a total of 100 CMP patients (DCM, n=50; ICM, n=50) between January 2004 and July 2008 were included. Table 1 summarizes the demographics, the most important clinical and hemodynamic characteristics, and the treatment of the patients. All patients had optimized heart failure therapy and planned heart transplantation according to American Heart Association Criteria. All patients underwent echocardiography, coronary angiography, right heart catheterization, and magnetic resonance imaging for assessment of ventricular function, my...

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Abstract

The invention discloses the use of glutathione S-transferase P1 (GSTP1) for the prevention or treatment of cardiomyopathies or ischemic heart diseases and for the diagnosis thereof.

Description

technical field [0001] The present invention relates to the application of glutathione-S-transferase P1. Background technique [0002] Glutathione S-transferases (GSTs) are a multigene family of isozymes that catalyze the nucleophilic attack of the sulfur atom of glutathione (GSH) on electrophilic groups of substrate molecules. GST is known as a detoxifying enzyme that conjugates toxic substances to GSH into a more water-soluble product that can be metabolized in the liver and eventually excreted from the body. On the basis of amino acid sequence, mammalian GSTs are classified into six classes: α, μ, ω, π, θ, and ζ. Among these isozymes, glutathione S-transferase P1 (GSTP1; GST-pi (GST-π), GSTP1-1) is the most prevalent class in mammalian cells. GSTP1 has attracted attention as a neoplastic marker because it is overexpressed in a variety of different human malignancies, including lung, colon, stomach, esophagus, oral cavity, kidney, ovary and testicular. Due to hypermethy...

Claims

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Application Information

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IPC IPC(8): A61K38/45A61P9/04C12Q1/68G01N33/50
CPCC12Q1/6883G01N2333/91177A61K38/45G01N2800/325C12Q2600/158A61P9/00A61P9/04A61P9/10A61P9/12Y02A50/30
Inventor S·阿哈里内贾德
Owner MEDIZINISCHE UNIVET WIEN
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