Compositional medicine for treating contrast-induced nephropathy

Abstract

The invention relates to a traditional Chinese medicinal compositional medicine for treating contrast-induced nephropathy (CIN), which is prepared from the following raw medicinal materials in parts by weight: 1-3 parts of prepared Radix Et Rhizoma Rhei and 1 parts of Ligusticum chuanxiong. The invention also provides application of the traditional Chinese medicinal compositional medicine. The compositional medicine of the invention has the advantages that the formulation of the traditional Chinese medicinal compositional medicine of the invention meets the traditional Chinese medicinal principle of assistant and guide; through the confirmation of pharmacodynamics experiments, the renal function of CIN model rat can be effectively protected, and the effect of controlling CIN is shown; mechanism study finds that the renal function of the rat can be protected by inhibiting the expression of caspase3 and then antagonizing apoptosis of rat renal tubular epithelial cells; and the compositional medicine has fewer number of bulk pharmaceutical chemicals, low toxic adverse effects and low cost, and is suitable for long-term administration. The new traditional Chinese medicinal composition for treating CIN is provided by the invention, and has good application prospects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine combination medicine, in particular to a traditional Chinese medicine combination medicine for treating contrast nephropathy. Background technique [0002] Contrast-induced nephropathy (CIN) refers to kidney disease caused by the use of iodine contrast media (CM), mainly manifested as acute renal failure (ARF). Recent studies have shown that the apoptosis of renal tubular epithelial cells is involved in the pathological process of CIN, and is considered to be the main cause of renal damage and renal failure caused by CM. [0003] CIN does not have a corresponding disease name in Chinese medicine, but because it mainly manifests as acute renal failure, it can be classified as "qualified" and "intoxicated". It is now clear that in high-risk groups, such as the elderly over 70 years old or patients with chronic kidney disease, diabetes, and hypertension, the use of iodine-containing contrast agents ...

AI Technical Summary

Problems solved by technology

Tan Qian et al. disclosed a traditional Chinese medicine prescription for the treatment of contrast-induced nephropathy, which consisted of raw rhubarb, raw oysters, salvia miltiorrhiza, dandelion, and Liuyuexue, and was suitable for patients with damp heat and turbidity. It is suitable for patients with cold-damp turbidity and toxins and patients with cold-heat mixed syndrome (for details, see: Tan Qian et al. TCM prevention and treatment of contrast-induced nephropathy [J]. Family Medicine, 2010: 29.) More, it is not convenient to prepare and use. At present, there is no report on a combination drug for the treatment of contrast-induced nephropathy with fewer medicinal flavors and significant curative effect.

Images