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Medicinal composition of radix salviae miltiorrhizae extract and application thereof

A composition and extract technology, applied in the field of pharmaceutical compositions, can solve the problems of inability to exert the overall therapeutic effect of Salvia miltiorrhiza medicinal materials, inability to reflect the compatibility and synergy of multi-component and multi-target points, limitations and the like

Inactive Publication Date: 2012-07-11
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] As mentioned above, the salvianolic acid B and tanshinone IIA sodium sulfonate preparations currently in clinical use use the main components of Danshen alone, and the compatibility involved in the above literature is also relatively limited, neither can play the overall therapeutic effect of Danshen medicinal materials , nor can it reflect the compatibility and synergy of multi-components and multi-targets

Method used

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  • Medicinal composition of radix salviae miltiorrhizae extract and application thereof
  • Medicinal composition of radix salviae miltiorrhizae extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Embodiment 1: Salvianolic acid B, salvianolic acid A and tanshinone IIA sodium sulfonate (5: 2: 1) lyophilized preparation

[0110] Get 20g of salvianolic acid B, 8g of salvianolic acid A and 4g of sodium tanshinone IIA sulfonate in Example 1, add 32g sodium ascorbate, 12.5g mannitol, dissolve in 350ml distilled water, settle to 400ml, filter and sterilize, without Under the condition of bacterium, it was divided into 100 vials, freeze-dried, and sealed under nitrogen.

Embodiment 2

[0111] Embodiment 2: Salvianolic acid B, salvianolic acid A and sodium tanshinone IIA sulfonate (3:1:1) lyophilized preparation

[0112] Get 21g of salvianolic acid B, 7g of salvianolic acid A and 7g of sodium tanshinone IIA sulfonate in Example 1, add 7.4g magnesium hydrogen phosphate, 35g sodium ascorbate, 12.5g mannitol, dissolve in 250ml distilled water, stir for 20 minutes, Dilute to 300ml, filter out insoluble matter, filter and sterilize, subpackage in 100 vials under aseptic conditions, freeze-dry, and seal under nitrogen to obtain the product.

Embodiment 3

[0113] Embodiment 3: Salvianolic acid B, salvianolic acid A and sodium tanshinone IIA sulfonate (9: 3: 2) freeze-dried powder injection

[0114] Take 18g of salvianolic acid B, 6g of salvianolic acid A and 4g of sodium tanshinone IIA sulfonate, add 6g of magnesium hydrogen phosphate, 27g of sodium ascorbate, and 12.5g of mannitol, dissolve in 250ml of distilled water, stir for 20 minutes, and filter out the insoluble matter. Sterilize by filtration, freeze-dry under aseptic conditions, divide the newly prepared powdery pharmaceutical composition into 100 vials, and seal it under nitrogen to obtain the product.

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Abstract

The invention relates to a medicinal composition of radix salviae miltiorrhizae extract and application thereof. The medicinal composition is the combination of salvianolic acid A or salvianolic acid B and tanshinone IIA sodium sulfonate, or combination of salvianolic acid A and salvianolic acid B and tanshinone IIA or tanshinone IIA sodium sulfonate. The therapeutic effect of the medicinal composition on myocardial infarction is better than that when the components are independently used; the multi-component multi-target therapeutic effect of the traditional Chinese medicine radix salviae miltiorrhizae can be better reflected; and the medicinal composition is used for preparing a medicine for treating vascular diseases. The medicinal composition can be processed into tablets, capsules, granules, freeze-dried preparation for injection, or freeze-dried preparation for injection or powder injection of carboxylate thereof.

Description

technical field [0001] The present invention relates to a pharmaceutical composition of main components of salvia miltiorrhiza extract, in particular to the composition of salvianolic acid A, salvianolic acid B, tanshinone IIA or a chemical modification of tanshinone IIA, sodium tanshinone IIA sulfonate extracted and refined from salvia miltiorrhiza A pharmaceutical composition and its use. Background technique [0002] Salvia miltiorrhiza Bge, as a traditional traditional Chinese medicine, was first recorded in "Shen Nong's Materia Medica". Physicians of all dynasties compared Salvia miltiorrhiza to "one taste of salvia miltiorrhiza Bge, the same function as the four substances" ("Siwu" means "Siwu Decoction", Composed of Angelica, Rehmannia, Chuanxiong, and Paeoniae Alba), the magical effect of Danshen can be seen. According to the 2010 edition of Chinese Pharmacopoeia, Salvia miltiorrhiza has the effects of promoting blood circulation and removing blood stasis, stimulati...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K31/58A61P9/10A61K31/216A61K31/343
Inventor 孙隆儒翟光喜朱海林谢婷婷季梅
Owner SHANDONG UNIV
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