Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Paclitaxel oral anticancer preparation obtained by nontoxic extraction from complete stool of Chinese yew and preparation method thereof

A yew and ethanol technology, applied in the preparation of alcoholic beverages, antitumor drugs, pharmaceutical formulations, etc., can solve rare problems and achieve the effects of improving product yield, simple operation, and effective activity without destroying

Inactive Publication Date: 2012-07-11
林树芳
View PDF3 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this 16-step non-toxic extraction process is rare in China

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0047] Taxol whole plant non-toxic extraction taxol oral anti-cancer preparation and preparation method thereof, the main process is:

[0048] 1. Extraction process

[0049] (1) Remove impurities, O 3 Wash with water, remove the soil and other impurities attached to the surface of the whole yew plant dry product of 100kg, put into O 3 Wash in the water washing pool.

[0050] (2) slicing, the 100kg yew whole plant after cleaning is taken out and drained, and cut into 2mm thick slices;

[0051] (3) drying, putting the yew flakes into a stainless steel tray, sending them into a 50-degree hot-air circulation drier for drying for 3 hours, and taking them out when the moisture content is below 5%;

[0052] (4) pulverize, the yew fragments after drying are pulverized through a stainless steel pulverizer again, and the granularity is below 1mm;

[0053] (5) ultrafine wall breaking, the 100kg yew powder after pulverizing is ultrafinely pulverized to 300 orders through a nanometer u...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a paclitaxel oral anticancer preparation obtained by nontoxic extraction from a complete stool of Chinese yew and preparation method thereof, which uses Chinese yew in Northeast China as the main raw material, by a ethanol immersion 16-step method and a nontoxic extraction technology, to obtain a 30% paclitaxel crude product, which is used as main raw material of paclitaxel drug wine and paclitaxel oral liquid. Based on drug effect research, the prepared oral anticancer preparation has greatly visble treatment effect on late period caser patients of 20 kinds of different singularity and the late period and anaphase cancer patients which is failure on combined chemotherapy, and the preparation has advantages of good ease pain effect and non-poison.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, which utilizes the artificially cultivated Northeast yew whole plant to soak in ethanol, extract paclitaxel in a non-toxic manner and prepare an oral anticancer preparation thereof. Background technique [0002] The production process of taxol extracted from Taxus, according to the current domestic and foreign relevant reports and related literatures, has the use of CO 2 Extraction, and ultrasonic extraction and other extraction process methods. Although CO2 extraction and ultrasonic extraction have advanced technology and high yield, paclitaxel and residues after treatment with certain chemical solvents still exist in equal amounts. The extracted raw materials are used as injection preparations. Although patients can tolerate their toxicity, But it will definitely cause secondary damage to the patient. If it is targeted at the late stage or cancer patients who have failed c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/13A61K9/08C12G3/04A61P35/00
Inventor 林树芳
Owner 林树芳
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com