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Preparation technology of aztreonam for injection

A preparation process, the technology of aztreonam, is applied in the direction of making medicines into special physical or taking forms of devices, antibacterial drugs, powder delivery, etc., and can solve problems such as poor antibacterial effect.

Inactive Publication Date: 2012-07-11
SUZHOU ERYE PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Aztreonam has a high degree of antibacterial activity against most aerobic Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae and Oxytobacter, aerogenes, cloacae, Proteus, sand Enterobacteriaceae such as Chrysobacterium, Citrobacter, and Shigella, as well as Influenza bacilli, Neisseria gonorrhoeae, and Neisseria meningitidis, etc., also have good antibacterial effects on Pseudomonas aeruginosa. Pseudomonas and Acinetobacter have poor antibacterial activity except for Pseudomonas aeruginosa, and have no antibacterial activity against aerobic Gram-positive bacteria such as Staphylococcus and Streptococcus and anaerobic bacteria

Method used

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  • Preparation technology of aztreonam for injection
  • Preparation technology of aztreonam for injection

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Embodiment Construction

[0021] The solutions of the present invention will be further described below in conjunction with specific examples. For the convenience of expression, the compounds mentioned are represented by their common names.

[0022] prescription

[0023] Aztreonam / Arginine 500 g (as aztreonam)

[0024] Packing 1000 bottles

[0025] Preparation Process

[0026] 1. Cleaning and sterilization of vials, butyl rubber stoppers and aluminum-plastic caps

[0027] Such as figure 1

[0028] 2. Packing

[0029] Such as figure 2

[0030] It should be noted that the above descriptions are only preferred embodiments of the present invention, and are not intended to limit the scope of the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention , should be included within the protection scope of the present invention.

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Abstract

The invention provides a preparation technology of aztreonam for injection. The formula comprises aztreonam and arginine. The preparation technology comprises the following steps of: cleaning and sterilizing a penicillin bottle, a butyl rubber plug and an aluminum-plastic cover; and sub-packaging.

Description

[0001] technical field [0002] The invention relates to the field of medicine, in particular to a preparation process of aztreonam for injection. Background technique [0003] Aztreonam was successfully developed by Bristol-Myers Squibb in the United States in 1981, and then it was launched in Italy (1984) and other European countries. In Asia, such as Japan, it was launched in 1987. In 1997, China approved the import of this product, and then it was produced by China-US Shanghai Bristol-Myers Squibb Company. Aztreonam has a high degree of antibacterial activity against most aerobic Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae and Oxytobacter, aerogenes, cloacae, Proteus, sand Enterobacteriaceae such as Chrysobacterium, Citrobacter, and Shigella, as well as Influenza bacilli, Neisseria gonorrhoeae, and Neisseria meningitidis, etc., also have good antibacterial effects on Pseudomonas aeruginosa. Except for Pseudomonas aeruginosa, Pseudomonas a...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/427A61P31/04A61J3/02
Inventor 徐立伽李晓冬宋柳柳
Owner SUZHOU ERYE PHARMA CO LTD
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