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Preparation method of reduction state graphene and platinum nanometer particle composite material modified molecularly imprinted membrane electrochemical sensor

A molecular imprinting and membrane electrochemistry technology, applied in the field of analysis and detection, can solve problems such as affecting the sensitivity of electrochemical sensors, and achieve the effects of increasing sensitivity, catalysis and high and excellent conductivity

Inactive Publication Date: 2012-07-04
NANJING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the preparation method of molecularly imprinted electrochemical sensors is mainly electropolymerization, but the molecularly imprinted films formed by electropolymerization are generally weakly conductive films, which affect the sensitivity of electrochemical sensors.

Method used

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  • Preparation method of reduction state graphene and platinum nanometer particle composite material modified molecularly imprinted membrane electrochemical sensor
  • Preparation method of reduction state graphene and platinum nanometer particle composite material modified molecularly imprinted membrane electrochemical sensor
  • Preparation method of reduction state graphene and platinum nanometer particle composite material modified molecularly imprinted membrane electrochemical sensor

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preparation example Construction

[0040] The preparation method of reduced graphene: take 3.0 g of graphite, add 120 ml of concentrated sulfuric acid, stir in an ice bath, and add a total of 16.0 g of potassium permanganate in three times. The reaction temperature was controlled to 35-40°C and stirred for 20 hours. After stirring, 250 ml of water was added in batches, heated in a water bath and stirred, and the temperature was controlled to 80° C., and the reaction was carried out for 2 hours, and the reactant gradually turned bright yellow. After cooling, 40 ml of hydrogen peroxide was added and stirred overnight to obtain oxidized graphene (GO). It was then washed with acid and water until pH was close to 6. Sonicate the GO for 1-2 hours. 60 mg of GO was added to 600 mg of sodium polystyrene sulfonate (PSS) for 30 min, and the mixture was stirred at 50 °C for 24 h. After cooling, 4 ml of ammonia water and 4 ml of hydrazine hydrate were added, and the mixture was kept at 95-100 °C and stirred for 24 h. Af...

Embodiment 1

[0043] a) Electrode pretreatment: glassy carbon electrode (Φ=3mm) was treated with 0.05μm Al 2 O 3 After polishing the suspension, put it in Piranha solution (30% H 2 O 2 : Concentrated H 2 SO 4 =3:7, V / V) for 2min, then ultrasonically cleaned with absolute ethanol and deionized water for 2min respectively;

[0044] b) Electrochemical deposition of platinum nanoparticles: The cleaned glassy carbon electrode was placed in a solution containing 0.5 mol·L -1 Sulfuric acid and 5mmol·L -1 In the mixed aqueous solution of hexachloroplatinic acid, in the potential range of -0.2 ~ 0.6V, at 30mV·s -1 The scan rate was cyclically scanned for 3 min; then rinsed with absolute ethanol and deionized water in turn, dried with nitrogen, and then soaked in Piranha solution for 2 min, rinsed with deionized water, and dried with nitrogen to obtain platinum nanoparticles modified electrode;

[0045] c) Assembly of reduced graphene and platinum nanoparticles: 5 μL of 0.5 mg / mL reduced grap...

Embodiment 2

[0049] a) Electrode pretreatment: glassy carbon electrode (Φ=3mm) was treated with 0.05μm Al 2 O 3 After polishing the suspension, put it in Piranha solution (30% H 2 O 2 : Concentrated H 2 SO 4 =3:7, V / V) for 2min, then ultrasonically cleaned with absolute ethanol and deionized water for 2min respectively;

[0050] b) Electrochemical deposition of platinum nanoparticles: The cleaned glassy carbon electrode was placed in a solution containing 0.5 mol·L -1 Sulfuric acid and 5mmol·L -1 In the mixed aqueous solution of hexachloroplatinic acid, in the potential range of -0.2 ~ 0.6V, at 50mV·s -1 The scan rate was cyclically scanned for 10 min; then rinsed with absolute ethanol and deionized water in turn, dried with nitrogen, and then soaked in Piranha solution for 2 min, rinsed with deionized water, and dried with nitrogen to obtain platinum nanoparticles modified electrode;

[0051] c) Assembly of reduced graphene and platinum nanoparticles: 10 μL of 0.5 mg / mL reduced gr...

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Abstract

The invention discloses a preparation method of a reduction state graphene and platinum nanometer particle composite material modified molecularly imprinted membrane electrochemical sensor. The method sequentially comprises the steps of electrode pretreatment process, platinum nanometer particle electrochemical deposition on the electrode surface, polyelectrolyte modification on the reduction state graphene, platinum nanometer particle assembly, molecularly imprinted layer self assembly, electro-polymerization reaction and template molecule elution. The molecularly imprinted membrane electrochemical sensor prepared by the preparation method provided by the invention has the advantages that the selectivity is good, the sensitivity and the anti-jamming capability are high, and the fast detection on trace environment estrogen in complex substrates can be carried out.

Description

technical field [0001] The invention belongs to the technical field of analysis and detection, and in particular relates to a preparation method of a molecularly imprinted membrane electrochemical sensor modified by a composite material of reduced graphene and platinum nanoparticles. Background technique [0002] In recent years, a large number of studies have shown that there are many substances in the environment that can simulate and interfere with animal and human body functions, such as estradiol, ethinyl estradiol and bisphenol A. After these exogenous estrogens enter the human body, they compete with the normally secreted hormones and bind to the hormone receptors in the cells, causing excess hormones in the human body, disorders of the endocrine system, affecting the normal work of human sex hormones, and various functional disorders. The residues of these estrogens have attracted great attention at home and abroad, and the detection of environmental estrogens such a...

Claims

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Application Information

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IPC IPC(8): G01N27/26G01N27/327
Inventor 周学敏姜慧君文婷婷王若禹李芸刘莳薛诚
Owner NANJING MEDICAL UNIV
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