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Combination drug used for killing genitals microorganisms of female Tibetan mastiffs and assisting reproduction

A technology of genitals and microorganisms, applied in the direction of drug combination, pharmaceutical formula, active ingredients of heterocyclic compounds, etc.

Inactive Publication Date: 2012-06-27
王爽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The acquired infertility of the female Tibetan Mastiff has an important reason, which is the microbial infection of its reproductive system. Combination drugs, therefore, the development of such drugs has a broad market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 2

[0018] A combination medicine for killing female Tibetan mastiff genital microorganisms and assisting reproduction: its specific dosage form is a liquid dosage form,

[0019] Its preparation method is first: matrine 3 g, podophyllotoxin 3 g, berberine 3 g, vitamin C 3 g, etoposide 3 g posaconazole 3 g, terbinafine hydrochloride 3 g with 75% ethanol 60 g was dissolved, and 40 g of azone was added for filtration sterilization, and then 140 g of 75% ethanol was added and mixed uniformly to obtain a liquid preparation, which was packed into a bottle.

specific Embodiment 3

[0021] A combined drug for killing genital microorganisms of female Tibetan mastiffs and assisting reproduction: its specific dosage form is a liquid dosage form; its preparation method is first: 1 g of matrine, 1 g of podophyllotoxin, 1 g of berberine, and vitamin C 1 g, 1 g of etoposide, 1 g of posaconazole, 1 g of terbinafine hydrochloride were dissolved in 30 g of 75% ethanol, 20 g of laurocapram was added to filter and sterilize, and then 100 g of 75% ethanol was added to mix evenly to obtain a liquid preparation , into bottles.

specific Embodiment 4

[0023] In the first group, 1 week before mating, the liquid of specific embodiment 1 was sprayed around the external genitalia of 6 female Tibetan mastiffs, and the dose was: 5g / time, 3 times / 1 day;

[0024] In the second group, 1 week before mating, the liquid of Embodiment 3 was sprayed around the external genitalia of 6 female Tibetan mastiffs, and the dosage was: 5g / time, 3 times / 1 day;

[0025] In the control group, 1 week before mating, dacryl emulsion was applied to the external genitalia of 6 female Tibetan mastiffs, the dose was: 5g / time, 3 times / day;

[0026] It was found that there was a significant difference in the effect of killing the fungus, and there was also a significant difference in the situation of assisted reproduction.

[0027] Group 1 and Group 2 had good broad antifungal effects. Inspect the fungus in the amniotic fluid of the 3 groups of female Tibetan mastiffs, observe the delivery situation, and record the following conditions:

[0028] ...

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PUM

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Abstract

The invention relates to a combination drug used for killing genitals microorganisms of female Tibetan mastiffs and assisting reproduction. The combination drug contains matrine, podophyllotoxin, berberine, vitamin C, etoposide and antifungal drugs in western medicine.

Description

technical field [0001] The invention relates to the field of veterinary medicines, in particular to a combination medicine for killing genital microorganisms of female Tibetan mastiffs and assisting reproduction. Background technique [0002] Female Tibetan mastiff infertility includes congenital infertility and acquired infertility. [0003] The congenital infertility of the female Tibetan Mastiff mainly refers to the abnormal genitals of the female Tibetan Mastiff, the existence of congenital defects, and the physical diseases of the female Tibetan Mastiff. The congenital infertility of the female Tibetan mastiff mainly has the following three situations, and it is not suitable for breeding. [0004] 1. Reproductive organ defects, some female Tibetan mastiffs have genital deformities, such as lack of vulva and vagina, or vaginal atresia, or excessive development of urethral valves, which may make the female Tibetan mastiff unable to fertilize smoothly. 2. Hermaphroditi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/4375A61K31/375A61K31/365A61P31/10A61P15/00A61K31/496A61K31/137A61K31/55
Inventor 不公告发明人
Owner 王爽
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