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Method for preparing nano hydroxyapatite

A technology of nano-hydroxyapatite and phosphate ions, which is applied in the field of preparation of nano-hydroxyapatite, can solve the problems of insufficient biological safety performance of synthetic templates, and achieve good biological safety, low cost and simple process

Inactive Publication Date: 2012-06-20
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to overcome the disadvantages of insufficient biosafety performance of the synthetic template of the existing nano-hydroxyapatite material, and to provide a nano-hydroxyapatite with simple preparation, low cost, mild reaction conditions, and green and safe synthesis. stone preparation method

Method used

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  • Method for preparing nano hydroxyapatite
  • Method for preparing nano hydroxyapatite
  • Method for preparing nano hydroxyapatite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment one: a kind of preparation method of nano-hydroxyapatite, comprises the following processing steps:

[0023] (1) CaCl 2 Dissolved in deionized water to prepare a calcium ion solution with a calcium ion concentration of 0.04mol / L;

[0024] (2) Sodium lauryl sulfate and polyvinylpyrrolidone are dissolved in deionized water to prepare a sodium lauryl sulfate-polyvinylpyrrolidone mixed solution; in the sodium lauryl sulfate-polyvinylpyrrolidone mixed solution The concentration of sodium lauryl sulfate is 0.5mmol / L, and the concentration of polyvinylpyrrolidone is 1g / L;

[0025] (3) Na 2 HPO 4 12H 2 O, (NH 4 ) 2 HPO 4 , NaH 2 PO 4 , NH 4 h 2 PO 4 、KH 2 PO 4 、K 2 HPO 4 ·3H 2 O, Na 3 PO 4 and Na 3 PO 4 12H 2 O is dissolved in the sodium lauryl sulfate-polyvinylpyrrolidone mixed solution that step (2) obtains, so that the concentration of phosphate ion in the sodium lauryl sulfate-polyvinylpyrrolidone mixed solution is 2mmol / L; The hydrochloric a...

Embodiment 2

[0032] Embodiment two: a kind of preparation method of nano-hydroxyapatite, comprises the following process steps:

[0033] (1) CaCl 2 and Ca(NO 3 ) 2 Dissolved in deionized water to prepare a calcium ion solution with a calcium ion concentration of 0.17mol / L;

[0034] (2) Sodium lauryl sulfate and polyvinylpyrrolidone are dissolved in deionized water to prepare a sodium lauryl sulfate-polyvinylpyrrolidone mixed solution; in the sodium lauryl sulfate-polyvinylpyrrolidone mixed solution The concentration of sodium lauryl sulfate is 3.6mmol / L, and the concentration of polyvinylpyrrolidone is 3g / L;

[0035] (3) Na 2 HPO 4 12H 2 O, (NH 4 ) 2 HPO 4 , NaH 2 PO 4 , NH 4 h 2 PO 4 、KH 2 PO 4 、K 2 HPO 4 ·3H 2 O and Na 3 PO 4 Be dissolved in the sodium lauryl sulfate-polyvinylpyrrolidone mixed solution that step (2) obtains, make the concentration of phosphate ion in the sodium lauryl sulfate-polyvinylpyrrolidone mixed solution be 6mmol / L; The hydrochloric acid solu...

Embodiment 3

[0040] Embodiment three: a kind of preparation method of nanometer hydroxyapatite, comprises the following processing steps:

[0041] (1) Ca(NO 3 ) 2 Dissolved in deionized water to prepare a calcium ion solution with a calcium ion concentration of 0.30mol / L;

[0042] (2) Sodium lauryl sulfate and polyvinylpyrrolidone are dissolved in deionized water to prepare a sodium lauryl sulfate-polyvinylpyrrolidone mixed solution; in the sodium lauryl sulfate-polyvinylpyrrolidone mixed solution The concentration of sodium lauryl sulfate is 7mmol / L, and the concentration of polyvinylpyrrolidone is 5g / L;

[0043] (3) Na 2 HPO 4 12H 2 O, (NH 4 ) 2 HPO 4 , NaH 2 PO 4 , NH 4 h 2 PO 4 、KH 2 PO 4 and K 2 HPO 4 ·3H 2 O is dissolved in the sodium lauryl sulfate-polyvinylpyrrolidone mixed solution that step (2) obtains, so that the concentration of phosphate ion in the sodium lauryl sulfate-polyvinylpyrrolidone mixed solution is 10mmol / L; The hydrochloric acid solution of 0.10m...

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Abstract

The invention relates to a method for preparing nano hydroxyapatite. The method comprises the following steps of: dissolving soluble calcium salt in deionized water to obtain a calcium ion solution; dissolving 0.5 to 7mmol of lauryl sodium sulfate and 1 to 5g of polyvinylpyrrolidone in each liter of deionized water to obtain a mixed solution; dissolving soluble phosphate in the mixed solution, adjusting the acidity of a system by using hydrochloric acid and ammonia water to ensure that the pH value of the solution is 8.0 to 11.0, and slowly dripping the calcium ion solution into the mixed solution of the lauryl sodium sulfate, the polyvinylpyrrolidone and phosphate radical ions at a constant temperature to ensure that the molar ratio of Ca to P is 10:6 in a reaction system after the dripping step is finished; and reacting for more than 24 hours, cooling, filtering, washing, drying under vacuum, and thus obtaining a nano hydroxyapatite material. The preparation method provided by the invention is environment-friendly, safe and low in cost and has a simple process; and the obtained nano hydroxyapatite has regular appearance and has important application value in the field of biomedical engineering.

Description

technical field [0001] The invention relates to a method for preparing nano-hydroxyapatite, in particular to a method for preparing nano-hydroxyapatite in an aqueous solution system. Background technique [0002] As the main inorganic component of human bones and teeth, hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) has good biocompatibility and bioactivity, and has been widely used in the repair and replacement of bone tissue in clinical medicine, Haque, S.; Rehman, I.; Darr, J.A., Synthesis and characterization of grafted nanohydroxyapatites using functionalized surface agents, LANGMUIR, 2007, 23(12): 6671-6676, compared with commonly used micron-scale materials, nanomaterials have many unique properties, and studies have shown that nano-hydroxyapatite may be the basic material of biological minerals Building blocks, Tang, R.; Wang, L.; Orme, C.A.; Bonstein, T.; Bush, P.J.; ): 2697-2701, nano-hydroxyapatite particles can exist stably in the environment in vivo and interact ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00
Inventor 李玲刘方刚杜鹏飞方云孙胜楠夏咏梅
Owner JIANGNAN UNIV
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