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Pharmaceutical compositions of fat-soluble vitamins for injection and water-soluble vitamins for injection and preparation method thereof

A technology of fat-soluble vitamins and water-soluble vitamins, which is applied in the direction of drug combinations, active ingredients of hydroxyl compounds, active ingredients of heterocyclic compounds, etc., and can solve problems such as vitamin stability, vitamin curative effect reduction, and human health damage. , to achieve the effect of improving clinical application quality and bioavailability, improving safety and saving costs

Active Publication Date: 2012-06-20
HAINAN YONGTIAN PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

③ Most of the vitamins cannot be synthesized by the body or the amount of synthesis is insufficient to meet the needs of the body and must be obtained from food frequently
④The human body has a very small requirement for vitamins, and the daily requirement is often calculated in milligrams (mg) or micrograms (μg), but once it is deficient, it will cause corresponding vitamin deficiency and cause damage to human health
The above-mentioned mixed preparations do not actually solve the technical problem of vitamin stability well, and also lead to the reduction of the curative effect of vitamins.

Method used

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  • Pharmaceutical compositions of fat-soluble vitamins for injection and water-soluble vitamins for injection and preparation method thereof
  • Pharmaceutical compositions of fat-soluble vitamins for injection and water-soluble vitamins for injection and preparation method thereof
  • Pharmaceutical compositions of fat-soluble vitamins for injection and water-soluble vitamins for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1 Preparation of Combination Packaged Drugs

[0053] 1. Preparation of fat-soluble vitamin (I) for injection

[0054] (1) Weigh vitamin A 415mg, vitamin E 3.5g, vitamin D 2 6mg, Vitamin K 1 120mg and 150g Tween 80, 50g Tween 20, 80g absolute ethanol, stir and mix until the main drug is completely dissolved, then add 1800ml of water for injection, stir well, add 160g of mannitol, stir to dissolve, add injection Water to 2000ml;

[0055] (2) Adjust the pH value to 6.5 with 1mol / L sodium hydroxide solution, add 0.6g of activated carbon to stir and adsorb, and filter for decarburization;

[0056] (3) Fine filtration, sub-packaging, 2ml / bottle;

[0057] (4) Freeze-drying: a. Pre-freezing: cool down the subpackaged drug solution to -40 ° C at a rate of 2 ° C / min, and keep it frozen for 3 hours; b. Sublimation: vacuumize the pre-frozen drug to 15 Pa , then slowly increase the temperature to -20°C within 8 hours, keep the temperature for 2 hours, and then increa...

Embodiment 2

[0064] Example 2 Preparation of Combination Packaged Drugs

[0065] 1. Preparation of fat-soluble vitamin (II) for injection

[0066] (1) Weigh vitamin A 1.089g, vitamin E 10.01g, vitamin D 2 5.5mg, vitamin K 1 0.165g and 200g Tween 80, 60g Tween 20, 120g absolute ethanol, stir and mix until the main ingredient is completely dissolved, then add 1800ml of water for injection, stir well, add 160g of mannitol, stir to dissolve, add Water for injection up to 2000ml;

[0067] (2) Adjust the pH value to 5.0 with 1mol / L sodium hydroxide solution, add 0.6g of activated carbon to stir and adsorb, and filter for decarburization;

[0068] (3) Fine filtration, sub-packaging, 2ml / bottle;

[0069] (4) Freeze-drying: a. Pre-freezing: cool down the subpackaged drug solution to -40 ° C at a rate of 2 ° C / min, and keep it frozen for 3 hours; b. Sublimation: vacuumize the pre-frozen drug to 15 Pa , then slowly increase the temperature to -20°C within 8 hours, keep the temperature for 2 ...

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Abstract

The invention relates to pharmaceutical compositions of fat-soluble vitamins for injection and water-soluble vitamins for injection, in particular to a combined application package including two types, namely the fat-soluble vitamins for injection and the water-soluble vitamins for injection. Water for injection or glucose injection is firstly used for dissolution and intravenous drip is further respectively performed during the use. The combined application package disclosed by the invention can comprehensively supplement the vitamins required for a human body, avoid the defects caused by the use of the single vitamin and greatly improve the treatment effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition of vitamins for injection, in particular to a composition of fat-soluble vitamins and water-soluble vitamins for injection, a preparation method and application packaging, and belongs to the technical field of medicine. Background technique [0002] Vitamins are a type of trace organic substances necessary for humans and animals to maintain normal physiological functions. They play an important role in the process of human growth, metabolism, and development. When humans and animals lack vitamins, they cannot grow normally and develop specific lesions. , the so-called vitamin deficiency. [0003] Vitamins are also known as vitamins. Generally speaking, they are life-sustaining substances. They are a type of organic substances necessary to maintain human life activities, and are also important active substances to maintain human health. Vitamins are present in small amounts in the body, but they are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K31/592A61K31/525A61K31/519A61K31/51A61K31/455A61K31/4415A61K31/4188A61K31/375A61K31/355A61K31/197A61K31/122A61K31/07A61K9/19A61P3/02
Inventor 廖爱国曹丽梅吕强张凤李双喜
Owner HAINAN YONGTIAN PHARMA INST
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