Succinic acid separating apparatus and method based on full membrane separation system

A membrane separation system and separation device technology, applied in semi-permeable membrane separation, chemical instruments and methods, separation/purification of carboxylic acid compounds, etc., can solve problems such as insufficient coupling between separation process and fermentation process, and achieve reasonable unit operation design , The effect of short process route and high yield

Active Publication Date: 2012-05-30
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Description
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  • Application Information

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Problems solved by technology

[0011] The object of the present invention is to provide a succinic acid separation device based on a full-membrane separation system in order to solve the problem of insufficient coupling between the separation process and the fermentation process

Method used

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  • Succinic acid separating apparatus and method based on full membrane separation system
  • Succinic acid separating apparatus and method based on full membrane separation system
  • Succinic acid separating apparatus and method based on full membrane separation system

Examples

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Effect test

Embodiment 1

[0044] Using glucose as carbon source, Actinobacillus succinate BE-1 is the succinic acid fermentation broth produced by the fermentation of the production strain, in which the concentration of succinic acid is 76g / L, the concentration of formic acid is 8g / L, and the concentration of acetic acid is 10g / L , the concentration of lactic acid is 5g / L, the amount of residual sugar is less, and the pH of the fermentation broth is 6.8.

[0045] After the fermentation broth is operated by microfiltration membrane, the removal rate of bacteria is 95%, and the removal rate of protein is 35%. The microfiltration operation adopts hollow fiber microfiltration membrane. The organic membrane adopts the method of cross-flow operation, and the operating temperature is 25°C. The obtained microfiltration permeate is subjected to ultrafiltration operation. The ultrafiltration operation adopts hollow fiber membrane equipment. The membrane material is organic membrane. ℃, the operating pressure is...

Embodiment 2

[0048] Using glucose as the carbon source, Actinobacillus succinate BE-1 is the succinic acid fermentation broth produced by the fermentation of the production strain, in which the concentration of succinic acid is 85g / L, the concentration of formic acid is 10g / L, and the concentration of acetic acid is 15g / L , the concentration of lactic acid is 3g / L, there is no residual sugar, and the pH of the fermentation broth is 6.8.

[0049] The fermentation broth is processed by two processes.

[0050] Process 1: After the fermentation broth is operated by microfiltration membrane, the removal rate of bacteria is 93%, and the removal rate of protein is 32%. The microfiltration operation adopts hollow fiber microfiltration membrane, and the pore size of the microfiltration membrane is 0.1 μm. The membrane material is organic membrane, and the cross-flow operation method is adopted, and the operating temperature is 25°C. The obtained microfiltration permeate is subjected to ultrafiltra...

Embodiment 3

[0054] The succinic acid fermentation broth is fermented with glucose as the carbon source and genetically engineered Escherichia coli as the production strain, in which the concentration of succinic acid is 92g / L, the concentration of formic acid is 12g / L, the concentration of acetic acid is 17g / L, and the concentration of lactic acid The concentration is 5g / L, no residual sugar, and the pH of the fermentation broth is 6.7.

[0055] The process of fermentation liquid treatment is as follows: the fermentation liquid is subjected to microfiltration operation, and the microfiltration operation adopts hollow fiber microfiltration membrane. The pore size of the microfiltration membrane is 0.1 μm. The temperature is 25°C. After microfiltration, the removal rate of bacteria is 94%, and the removal rate of protein is 35%. The microfiltration permeate is subjected to ultrafiltration operation. The ultrafiltration operation adopts hollow fiber membrane equipment, and the membrane materi...

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Abstract

The invention relates to a succinic acid separating apparatus and a succinic acid separating method based on a full membrane separation system. According to the invention, the full membrane separation system of the succinic acid separating apparatus comprises a membrane component (5). The apparatus also comprises a fermentation tank (1) and a pump (3). The fermentation tank (1), the pump (3) and the membrane component (5) in the full membrane separation system form a circuit, such that the coupling of succinic acid fermentation and separation is realized. According to the apparatus provided by the invention, the succinic acid fermentation technology and the succinic acid separation technology are coupled, such that high concentration inhibition of succinic acid during a fermentation process is relieved, and high-density succinic acid fermentation broth can be obtained. Therefore, the production intensity can be improved, the succinic acid production period can be shortened, and the production efficiency can be improved.

Description

technical field [0001] The invention relates to the field of succinic acid separation in the fermentation industry, in particular, the invention relates to a succinic acid separation device and method based on a full-membrane separation system. Background technique [0002] Succinic acid (Succinic acid), also known as succinic acid, widely exists in organisms, is an important dibasic organic carboxylic acid, and is also an important metabolite of microbial tricarboxylic acid cycle and glycolysis pathway. Due to its unique structure and chemical properties, succinic acid has a wide range of uses in many fields, and can be used in the synthesis of degradable plastics, tranquilizers in the pharmaceutical field, food additives in the food industry, surfactants and others. The synthesis of succinic acid consists of a traditional chemical synthesis method and a new biological fermentation method, because the biological fermentation method has low raw materials and can fix CO 2 It...

Claims

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Application Information

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IPC IPC(8): C07C55/10C07C51/42B01D61/58
Inventor 邢建民王彩霞李强王丹张云剑唐煌万印华苏仪
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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