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Ivermectin transdermal liniment for animals

A technology of ivermectin and smear, which is applied in the field of medicine for animals, can solve the problems of wasting liquid medicine, large area of ​​medicine, and difficult to control the dosage of medicine, so as to increase percutaneous absorption, reduce toxic and side effects, and reduce drug consumption. The effect of resolution

Inactive Publication Date: 2012-05-09
INNER MONGOLIA AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a kind of ivermectin transdermal varnish for animals. The present invention can overcome the existing problems of pouring dosage forms such as relatively large medication area, difficult control of dosage, and waste of medicinal liquid. A kind of ivermectin transdermal ointment for animals with new route of administration, long maintenance time of effective blood drug concentration, less toxic and side effects and convenient use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: A kind of ivermectin transdermal ointment for animals is prepared by the following steps: weigh 0.5g ivermectin (IVM) and add it to a 100mL volumetric flask, and dissolve it completely with ethyl acetate to obtain Ivermectin Ivermectin solution: Add 3mL of azone and 57mL of propylene glycol in sequence, dilute to the mark with ethyl acetate and stir evenly until the white ivermectin powder is completely dissolved without visible precipitation. Then filter the prepared solution with a disposable microporous membrane, and make a finished product after filling. Place it for a certain period of time, and then carefully check for insoluble substances before use.

Embodiment 2

[0010] Embodiment 2: A kind of ivermectin transdermal ointment for animals is prepared by the following steps: weigh 0.6g ivermectin (IVM) and add it to a 100mL volumetric flask, and dissolve it completely with ethyl acetate to obtain Ivermectin Ivermectin solution: Add 4mL of azone and 70mL of propylene glycol in sequence, dilute to the mark with ethyl acetate and stir until the white ivermectin powder is completely dissolved without visible precipitation. Then filter the prepared solution with a disposable microporous membrane, and make a finished product after filling. Place it for a certain period of time, and then carefully check for insoluble substances before use.

Embodiment 3

[0011] Embodiment 3: a kind of ivermectin transdermal varnish for animals is prepared by following steps: weigh 1g ivermectin (IVM) and add in 100mL volumetric flask, dissolve completely with ethyl acetate, obtain ivermectin Add 5mL of azone and 60mL of propylene glycol in sequence, dilute to the mark with ethyl acetate and stir until the white ivermectin powder is completely dissolved without visible precipitation. Then filter the prepared solution with a disposable microporous membrane, and make a finished product after filling. Place it for a certain period of time, and then carefully check for insoluble substances before use.

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PUM

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Abstract

The invention discloses an ivermectin transdermal liniment for animals, which is prepared from medicinal liquor and ivermectin, wherein the medicinal liquor is prepared from the following components in percentage by volume: 20-40% of ethyl acetate, 2-5% of azone and 55-75% of propylene glycol; and the ratio of ivermectin to medicinal liquor is (0.5-1g):100mL. The novel transdermal accelerator selected in the formula can enhance the absorption of skin for medicines, does not have toxicity or irritation on the skin and body, does not have pharmacological action, and does not react with the medicines and other additives. The invention is simple to prepare and convenient to use, has high stability, and can achieve favorable anthelminthic effect.

Description

technical field [0001] The invention relates to a medicament for animals, in particular to an ivermectin transdermal ointment for animals. Background technique [0002] As a new way of non-invasive drug delivery, the transdermal drug delivery system can avoid the first-pass effect of the drug in the liver and the damage to the drug in the gastrointestinal tract compared with the traditional drug delivery system. The transdermal drug delivery system can produce a sustained, constant and controllable drug delivery rate and blood drug concentration, improve the bioavailability of the drug, it has a sustained release effect, can reduce the number of times and doses of drug administration, and reduce adverse reactions. Body surface, convenient use and interruption of administration, etc., provide a brand-new medication method for drugs that are not suitable for oral administration or injection. Parasitic diseases are important diseases that seriously hinder the development of an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/7048A61K47/22A61P33/00A61P33/10A61P33/14
Inventor 王凤龙朱美乐王仲兵丁玉林刘兴国郑明学王金玲
Owner INNER MONGOLIA AGRICULTURAL UNIVERSITY
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