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Controlled-release enteric acrylic resin latex and preparation method thereof

A technology of acrylic resin and latex, which is applied in the field of pharmaceutical excipients, can solve the problems of high cost of film-forming materials, easy to break, and brittle film formation, and achieve good release effect, good water permeability resistance, and low energy consumption. Effect

Active Publication Date: 2012-05-02
连云港万泰医药辅料技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The slow-release enteric-coated acrylic resin in the prior art can only be dissolved in the small intestine with pH ≥ 5.5 or the large intestine with pH ≤ 7, and cannot be insoluble under the environment of PH ≤ 7. Colon localized release; or use organic solvent as the solvent, the film is formed through the evaporation of the solvent, so that the distance between the polymer chains is getting closer and closer to contact, and the film is brittle and easy to break
At the same time, the cost of film-forming materials using organic solvents as solvents is high; in addition, organic solvent coating also has disadvantages in terms of safety (explosive), environmental protection (organic solvents are polluted), etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, a kind of slow-release enteric-coated acrylic resin latex liquid, it is made of the raw material of following weight ratio:

[0026] Methacrylic acid 100; Methyl acrylate 79;

[0027] Methyl methacrylate 95; Purified water 638;

[0028] Potassium persulfate or ammonium persulfate 1.23; Sodium lauryl sulfate 0.85;

[0029] Polysorbate 80 2.41;

[0030] Prepared by conventional methods in the prior art.

Embodiment 2

[0031] Embodiment 2, a kind of slow-release enteric-coated acrylic resin emulsion, it is made of the raw material of following weight ratio:

[0032] Methacrylic acid 100; Methyl acrylate 105;

[0033] Methyl methacrylate 128; Purified water 789;

[0034] Potassium persulfate or ammonium persulfate 2.03; Sodium lauryl sulfate 1.76;

[0035] Polysorbate 80 4.10.

[0036] The preparation method step of described sustained-release enteric-coated acrylic resin emulsion is as follows:

[0037] (1) Add purified water, potassium persulfate or ammonium persulfate, sodium lauryl sulfate, and polysorbate 80 weighed according to the weight ratio into the reaction kettle, stir the reaction kettle, and dissolve the The reactor was heated to 85°C;

[0038] (2) Mix methacrylic acid, methyl acrylate, and methyl methacrylate weighed according to the weight ratio into the high-level tank, and then drop them into the reactor. After the addition is completed, control the temperature of the re...

Embodiment 3

[0039] Embodiment 3, a kind of slow-release enteric-coated acrylic resin latex liquid, it is made of the raw material of following weight ratio:

[0040] Methacrylic acid 100; Methyl acrylate 85;

[0041] Methyl methacrylate 110; Purified water 700;

[0042] Potassium persulfate 1.65; Sodium lauryl sulfate 1.35;

[0043] Polysorbate 80 3.20.

[0044] The preparation method step of described sustained-release enteric-coated acrylic resin emulsion is as follows:

[0045] (1) Add purified water, potassium persulfate, sodium lauryl sulfate, and polysorbate 80 weighed according to the weight ratio into the reactor, stir the reactor, and heat the reactor within 60 minutes to 63°C;

[0046] (2) Mix methacrylic acid, methyl acrylate, and methyl methacrylate weighed according to the weight ratio into the high-level tank, and then drop them into the reaction kettle. After the addition is completed, control the temperature of the reaction kettle at 106 ℃ and continue to react for 90...

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Abstract

The invention discloses a controlled-release enteric acrylic resin latex which is characterized by being prepared from the following raw materials in percentage by weight: 100 percent of methacrylic acid, 79-105 percent of methyl acrylate, 95-128 percent of methyl methacrylate, 638-789 percent of purified water, 1.23-2.03 percent of potassium persulfate or ammonium persulfate, 0.85-1.76 percent of lauryl sodium sulfate and 2.41-4.10 percent of polysorbate 80. The invention also relates to a preparation method of the controlled-release enteric acrylic resin latex. The controlled-release enteric acrylic resin latex disclosed by the invention can be used as a colon-specific delivery coating material or can be used as a controlled-release skeleton material of a solid preparation, is convenient in use and good in controlled-release effect.

Description

technical field [0001] The invention relates to a pharmaceutical auxiliary material, in particular to a slow-release enteric-coated acrylic resin latex; the invention also relates to a preparation method of the slow-release enteric-coated acrylic resin latex. Background technique [0002] The slow-release enteric-coated acrylic resin in the prior art can only be dissolved in the small intestine with pH ≥ 5.5 or the large intestine with pH ≤ 7, and cannot be insoluble under the environment of PH ≤ 7. Colon-directed release; or use organic solvents as the solvent, the film is formed through the evaporation of the solvent, the distance between the polymer chains is getting closer and closer until they come into contact, and the film is brittle and easy to break. At the same time, the cost of film-forming materials using organic solvents as solvents is high; in addition, organic solvent coating also has disadvantages in terms of safety (explosive), environmental protection (orga...

Claims

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Application Information

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IPC IPC(8): C08F220/06C08F220/14C08F2/26C08F2/30A61K47/32A61K9/32
Inventor 张绍国
Owner 连云港万泰医药辅料技术有限公司
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