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Application of glucal and glucal derivative in preparation of drugs

A technology of gluculose and medicine is applied in the application field of gluculose and its derivatives in the preparation of medicines, and can solve problems such as unreported applications

Active Publication Date: 2014-02-05
SUZHOU HARMONY BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, glucal and its derivative triacetylglucal are mainly used as synthetic intermediates, and the application of the above functions has not been reported.

Method used

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  • Application of glucal and glucal derivative in preparation of drugs
  • Application of glucal and glucal derivative in preparation of drugs
  • Application of glucal and glucal derivative in preparation of drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] D-glucal antibacterial test:

[0023] Take the stock solution prepared by D-glucal 5g and 20mL propylene glycol, shake it well, make it even, and set aside. According to aseptic operation, take 8 bottles numbered A-F, and use the doubling dilution method to dilute the concentration to 1 / 2, 1 / 4, 1 / 8, 1 / 16, 1 / 32 of the stock solution concentration, and make a blank control. As follows: A: 15mL stock solution + 15mL propylene glycol, add 1mL of the remaining solution to 6 test tubes; B: 15mLA + 15mL propylene glycol, add 1mL of the remaining solution to 6 test tubes; C: 15mLB + 15mL propylene glycol, Add 1mL of the remaining solution to 6 test tubes; D: 15mL LC + 15mL propylene glycol, add 1mL of the remaining solution to 6 test tubes; E: 15mL D + 15mL propylene glycol, add 1mL of the remaining solution to 6 test tubes In a test tube; F: 15mL LE + 15mL propylene glycol, add 1 mL of the remaining solution to 6 test tubes; G: 3 mL propylene glycol, add 1 mL to 2 test tubes;...

Embodiment 2

[0029] Anti-inflammatory test of D-glucose mice:

[0030] The effect on mouse toe swelling and the effect of PGE2 exudation in inflammatory tissue (expressed as OD value)

[0031] Note; PGE2 prostaglandin E2 model: mouse paw egg white-induced inflammation method

[0032] test results:

[0033]

[0034] The test results in the table above show that D-glucal has a significant effect in inhibiting egg white-induced toe swelling, and is superior to hydrocortisone at high concentrations and doses. At the same time, it can effectively inhibit the exudation of PGE2 in toe swelling caused by egg white, and the effect is better than hydrocortisone

Embodiment 3

[0036] D-glucose antiviral test:

[0037] The 50% effective concentration (EC50) was calculated by Reed-Mucnch method and the therapeutic index IT=(using CC50 / EC50), the higher the IT value, the stronger the effect.

[0038] Virus strain:

[0039] Influenza virus A3, parainfluenza virus HVJ, adenovirus type 3, 7 (AdV3, 7), herpes simplex virus type I, II (HSVI, II)

[0040] Effect of D-glucal on cytopathic effect of virus

[0041] Virus

[0042] The results of in vitro antiviral tests show that D-glucal has different degrees of inhibitory effects on the above six viruses.

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Abstract

The present invention provides an application of glucal and a glucal derivative in preparation of drugs, specifically an application of the glucal and the glucal derivative in preparation of blood glucose reducing drugs, antiviral drugs, wound repairing drugs, anti-tumor drugs or anti-aging drugs. The glucal and the glucal derivative of the present invention comprise D-glucal and triacetylglucal. According to the present invention, with determinations by animal tests and in vitro tests, the results show that: the glucal and the glucal derivative have effects of blood glucose reducing, virus resistance, wound repairing, tumor resistance or aging resistance. The drugs of the present invention are oral tablets, capsules, oral solutions or granules or transdermic absorption injections or transdermic absorption patches, wherein the oral tablets, the capsules, the oral solutions or the granules or the transdermic absorption injections or the transdermic absorption patches are prepared by the glucal or the glucal derivative and a conventional pharmaceutic adjuvant according to a conventional method, the glucal or the glucal derivative is adopted as the active ingredient. The glucal and the glucal derivative of the present invention have great practical values in the field of medicine.

Description

technical field [0001] The present invention relates to medicinal chemistry. It specifically relates to the application of glucuronose and its derivatives in the preparation of medicines. In particular, it relates to the application of glucal and its derivatives in the preparation of antibacterial, anti-inflammatory, wound repair, antiviral, antitumor, hypoglycemic and antiaging drugs. Background technique [0002] Glycochemistry and glycobiology have now become the frontier and hot areas of life sciences. Sugars not only serve as energy sources or structural components in living organisms, but also undertake extremely important biological functions. Oligosaccharides in glycocomplexes are information molecules in the body, which play an important role in the occurrence, development and prognosis of human diseases, and are also an important class of therapeutic drugs. [0003] The main functions of carbohydrate drugs are as follows: Improving immunity, lowering blood sugar,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/351A61P3/10A61P31/04A61P31/12A61P17/02A61P35/00A61P39/00A61P39/06A61P31/22A61P31/16A61P35/02
Inventor 冒华
Owner SUZHOU HARMONY BIOTECH
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